Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible
AUTOR(ES)
HWANG, Young Sun, HAN, Sang-Sun, KIM, Ki-Rim, Ye-Jin, LEE, Sun-Kyung, LEE, Kwang-Kyun, PARK, Won-Yoon, CHUNG
FONTE
J. Appl. Oral Sci.
DATA DE PUBLICAÇÃO
2015-02
RESUMO
Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.
Documentos Relacionados
- A magneto-motive ultrasound platform designed for pre-clinical and clinical applications
- Brown Flaxseed Prevents DNA Damage Induced by 1,2-Dimethylhydrazine in a Pre-Clinical Model
- Single port robot-assisted transperitoneal kidney transplant using the sp® surgical system in a pre-clinical model
- Preclinical mouse models for BRCA1-associated breast cancer
- Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations