Nuclear Receptors
Mostrando 25-36 de 1108 artigos, teses e dissertações.
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25. Mecanismos moleculares envolvidos na dominância negativa na síndrome de resistência ao hormônio tireoideano : I. genes regulados negativamente pelo receptor de hormônio tireoideano; II. genes regulados pelos receptores ativos por proliferadores de peroxissoma
A Síndrome de Resistência ao Hormônio Tireoideano (SRHT) é uma patologia caracterizada pela resposta reduzida dos tecidos-alvo ao hormônio tireoideano (HT). Ocorre comumente devido a mutações em um alelo do gene do receptor do hormônio tireoideano β (TRβ) que codifica para um TR mutante, o qual inibe a função do TRβ wt, fenômeno con
Publicado em: 2010
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26. Analise molecular do gene do receptor de androgenos em pacientes 46, XY com ambiguidade genital e produção normal de testosterona / Molecular analysis of the androgen receptor gene in patient 46, XY presenting genital ambiguity and normal testosterone production
Considera-se que insensibilidade androgênica seja a causa mais freqüente dos distúrbios da diferenciação do sexo em pacientes com cariótipo 46,XY. Trata-se de uma anomalia recessiva ligada ao cromossomo X, que pode se manifestar de forma branda, parcial ou completa, com um amplo espectro de variação fenotípica. O gene do receptor de andrógenos (AR)
Publicado em: 2010
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27. Morfoquantitative and chemical coding analyses of the purinergic P2X2 receptor in myenteric plexus of female and male obese mice (ob/ob). / Análises morfoquantitativa e do código químico do receptor purinérgico P2X2 no plexo mioentérico do íleo de camundongos obesos fêmeas e machos (ob/ob).
The intestinal activities are coordinated by enteric nervous system, and dysfunctions in intestinal motility were observed in obese individuals. The enteric neurons have been demonstrated to express different purinergics receptors. This study aims to analyze the expression of P2X2 receptor and the chemical code in the myenteric neurons in obesity. Sample fro
Publicado em: 2010
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28. The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats
In order to determine the modulation of anxiolytic and panicolytic-like effects of diazepam by the hormonal cycle of female rats, male and female rats - the latter divided per estrous cycle phase (estrus, diestrus, metaestrus and proestrus) - were tested in the elevated T-maze, a behavioral model of panic and anxiety. Diazepam (0.5, 1.0 and 2.0 mg/kg) or sal
Psychology & Neuroscience. Publicado em: 2009-12
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29. Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-γ genes and its association with susceptibility to tuberculosis
Mycobacterium tuberculosis kills more people than any other single pathogen, with an estimated one-third of the world's population being infected. Among those infected, only 10% will develop the disease. There are several demonstrations that susceptibility to tuberculosis is linked to host genetic factors in twins, family and associated-based case control st
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-04
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30. Nicotine effects on LPS-induced NF-capaB in the central nervous system / Efeito da nicotina na ativação do fator de transcrição NF-B no sistema nervoso central na vigência de estímulo inflamatório induzido por lipopolissacarídeo (LPS)
Nicotine is an alkaloid extracted from Tobacco plants, and it acts as an agonist in neurons and other cells that express nicotinic receptors. This substance crosses the blood brain barrier and mimics endogenous acetylcholine in interacting with various receptor subtypes. The hippocampus and cerebellum are brain regions rich in nicotinic receptors including 7
Publicado em: 2009
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31. Medium chain fatty acids like PPAR ligand / Ácidos graxos de cadeia média como ligantes da proteína PPAR
PPARs (peroxisome proliferator activated receptors) are nuclear receptors that regulate glucose and fat metabolism, adipogenesis and macrophage polarization and mediate actions of a major class of drugs that are used to treat type 2 diabetes, the thiazolidinediones. While TZDs reduce blood glucose and improve insulin sensitivity effectively, they can also ex
Publicado em: 2009
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32. Interaction of the nuclear receptors with its ligands: Structural studies of the thyroid hormone receptor, mineralocorticoid receptor and peroxisome proliferator-activated receptor / Interações dos receptores nucleares com seus ligantes: Estudos estruturais do receptor de hormônio tireoidiano, do receptor de mineralocorticóide e do receptor ativado por proliferadores peroxissomais
Nuclear receptors are a superfamily of hormone-regulated transcriptional factors. This superfamily includes, for example, the receptor for thyroid hormone, estrogen, androgen, gluco and mineralocorticoid. In this work, we used structural biology and bioinformatic tools to study the interactions between some members of the nuclear receptor superfamily and its
Publicado em: 2009
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33. Modulation of intracellular signaling pathways in insulin-producing cells lines by INGAP-PP / Analise das vias de sinalização intracelulares em linhagens de celulas produtoras de insulina expostas ao INGAP-PP
The pentadecapeptide comprising the 104-118 aminoacid sequence of the ilotropin-derived Reg3- related islet neogenesis associated protein (INGA-PP) has been implicated in pancreatic beta-cell neogenesis and enhancement of the insulin secretion in pancreatic islets. There is little information regarding the mechanism of action of the polypeptide. The aim of t
Publicado em: 2009
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34. Avaliação da cultura de células-tronco do epitélio olfatório de cães sem raça definida (Canis familiaris Linnaeus, 1758) / Evaluation of stem cell culture of olfactory epithelium from Mongrel dogs (Canis familiaris Linnaeus, 1758)
As células provenientes do epitélio olfatório apresentam capacidade regenerativa durante toda a vida, embora este mecanismo ainda não esteja completamente elucidado. O potencial de diferenciação de células-tronco provenientes do epitélio olfatório de cães sem raça definida (Canis familiaris Linnaeus, 1758) foi avaliado utilizando-se 12 cães adult
Publicado em: 2009
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35. Transporte de hormônios tireoideanos em hemácias de pacientes com hipertireoidismo ou hipotireoidismo primário
Thyroid hormones (THs) have important effects on cellular growth, differentiation and metabolism. They bind to thyroid hormone receptors (TRs), which belong to the nuclear hormone receptor superfamily. Because TRs are located intracellularly, TH action requires its transport from the extracellular compartment into target cells. It has become increasingly cle
Publicado em: 2009
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36. Expressão do Coativador-1 do Peroxisome Proliferator-Activated Receptor- (PGC-1) em fígado e músculos esqueléticos soleus e plantaris de ratos machos Wistar submetidos ao exercício físico voluntário crônico / Peroxisome Proliferator-Activated Receptor- - Coactivator-1 ( PGC-1 ) expression in the liver and skeletal muscles soleus and plantaris of male Wistar rats subjected to chronic voluntary exercise
INTRODUCTION: The Peroxisome Proliferator-Activated Receptor- - Coactivator 1 ( PGC-1 e ) is a protein responsible for the connection between environmental stimuli and cell metabolic response. Its presence is important in fat tissue, hepatic and skeletal muscle and in animals on brown fat tissue. Interact with nuclear receptors modulating the mitochondrial b
Publicado em: 2009