Non Target Effects
Mostrando 1-12 de 147 artigos, teses e dissertações.
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1. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Exploring Major Themes in Applied Linguistics: Local and Global Contexts
Abstract This study aims at showing how L1 word stress affects L2 word naming for cognates and non-cognates in two lexical stress languages, Brazilian Portuguese (BP, L1) and American English (AE, L2). Based on the bilingualism literature, there are indications that the access to the lexicon is non-selective, thus, cognate words would have a facilitation eff
Ilha Desterro. Publicado em: 2020-04
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3. Retrieving L2 word stress from orthography: Evidence from word naming and cross-modal priming
Abstract This study aims at showing how L1 word stress affects L2 word naming for cognates and non-cognates in two lexical stress languages, Brazilian Portuguese (BP, L1) and American English (AE, L2). Based on the bilingualism literature, there are indications that the access to the lexicon is non-selective, thus, cognate words would have a facilitation eff
Ilha Desterro. Publicado em: 2020-04
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4. Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegrad
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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5. Efficacy of Trichogrammatidae Species (Hymenoptera) Submitted to the Herbicide Glyphosate
RESUMO: Informações sobre herbicidas seletivos, incluindo o glyphosate, que não afetam organismos não alvo, como inimigos naturais, são importantes nos programas de manejo integrado de pragas na cultura do milho. O glyphosate, na dose de 13,94 L ha-1, foi avaliado em fêmeas de 10 espécies de Trichogrammatidae (Hymenoptera). Uma fêmea de cada espécie
Planta daninha. Publicado em: 02/12/2019
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6. The role of Survivin as a biomarker and potential prognostic factor for breast cancer
RESUMO O câncer de mama (CM) é um dos principais problemas de saúde em todo o mundo. Como o câncer mais comum em mulheres no mundo e no Brasil, precedido apenas pelo câncer de pele não melanoma, essa neoplasia corresponde a aproximadamente 28% dos novos casos por ano no país. O CM também afeta homens, embora a incidência corresponda a apenas 1% do t
Rev. Assoc. Med. Bras.. Publicado em: 22/07/2019
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7. In silico prediction of the functional and structural consequences of the non-synonymous single nucleotide polymorphism A122V in bovine CXC chemokine receptor type 1
Resumo O presente estudo objetivou avaliar se o polimorfismo causal A122V promove alterações nas propriedades funcionais e estruturais da proteína receptora de quimiocina CXC do tipo 1 (CXCR1) de bovino Bos taurus por análises in silico. Duas sequências de aminoácidos da CXCR1 bovina foram selecionadas a partir do banco de dados UniProtKB/Swiss-Prot:
Braz. J. Biol.. Publicado em: 18/04/2019
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8. Postnatal management of growth failure in children born small for gestational age
Resumo Objetivos: Discutir a etiologia e as consequências para o crescimento e as indicações, os efeitos e a segurança da terapia com hormônio de crescimento biossintético em crianças pequenas para idade gestacional. Fonte dos dados: Uma busca abrangente e não sistemática foi feita nas bases de dados PubMed, LILACS e SciELO de 1980 até a presente
J. Pediatr. (Rio J.). Publicado em: 18/04/2019
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9. Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells
Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell tra
Braz J Med Biol Res. Publicado em: 15/04/2019
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10. Atrazine and nicosulfuron affect the reproductive fitness of the predator Podisus nigrispinus (Hemiptera: Pentatomidae)
Abstract Herbicides can impact non-target metabolic pathways in natural enemies and lead to the reduction of these populations in the field. Behavioral characteristics, morphology and histology of reproductive structures and reproduction of females of Podisus nigrispinus (Dallas) (Hemiptera: Pentatomidae) were evaluated under the effect of the herbicides atr
An. Acad. Bras. Ciênc.. Publicado em: 03/09/2018
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11. In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonen
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
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12. Topical application of bFGF on acid-conditioned and non-conditioned dentin: effect on cell proliferation and gene expression in cells relevant for periodontal regeneration
Abstract Periodontal regeneration is still a challenge in terms of predictability and magnitude of effect. In this study we assess the biological effects of combining chemical root conditioning and biological mediators on three relevant cell types for periodontal regeneration. Material and Methods: Bovine dentin slices were conditioned with 25% citric acid
J. Appl. Oral Sci.. Publicado em: 2017-12