Non Target Effects
Mostrando 13-24 de 147 artigos, teses e dissertações.
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13. Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage
Kidney stone disease is a major cause of chronic renal insufficiency. The role of long non-coding RNAs (lncRNAs) in calcium oxalate-induced kidney damage is unclear. Therefore, we aimed to explore the roles of lncRNAs in glyoxylate-exposed and healthy mouse kidneys using microarray technology and bioinformatics analyses. A total 376 mouse lncRNAs were differ
Braz J Med Biol Res. Publicado em: 13/11/2017
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14. Impact Damage Analysis with Stress Continuity Constraints Fulfilment at Damaged-Undamaged Regions and at Layer Interfaces
Abstract Low-velocity impacts have a relevant importance for safety of laminated and sandwich composite structures, because they are highly susceptible to damage. In this paper, a 3D cost effective zig-zag model is developed in order to efficiently simulate such impacts. It a priori fulfills the continuity of out-of-plane stresses at layer interfaces, the co
Lat. Am. j. solids struct.. Publicado em: 2017-08
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15. Effects of monosulfuron-ester on metabolic processes of nitrogen-fixing cyanobacteria Anabaena flos-aquae and Anabaena azotica
Abstract Presence of the relatively new sulfonylurea herbicide monosulfuron-ester at 0.03-300 nmol/L affected the growth of two non-target nitrogen-fixing cyanobacteria (Anabaena flos-aquae and Anabaena azotica) and substantially inhibited in vitro Acetolactate synthase activity, with IC50 of 3.3 and 101.3 nmol/L for A. flos-aquae and A. azotica, respectivel
Braz. J. Microbiol.. Publicado em: 2017-07
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16. Short interfering RNAs targeting a vampire-bat related rabies virus phosphoprotein mRNA
Abstract The aim of this study was to assess the in vitro and in vivo effects of short-interfering RNAs (siRNAs) against rabies virus phosphoprotein (P) mRNA in a post-infection treatment for rabies as an extension of a previous report (Braz J Microbiol. 2013 Nov 15;44(3):879-82). To this end, rabies virus strain RABV-4005 (related to the Desmodus rotundus v
Braz. J. Microbiol.. Publicado em: 2017-07
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17. A cytotoxic Petiveria alliacea dry extract induces ATP depletion and decreases β-F1-ATPase expression in breast cancer cells and promotes survival in tumor-bearing mice
Abstract Metabolic plasticity in cancer cells assures cell survival and cell proliferation under variable levels of oxygen and nutrients. Therefore, new anticancer treatments endeavor to target such plasticity by modifying main metabolic pathways as glycolysis or oxidative phosphorylation. In American traditional medicine Petiveria alliacea L., Phytolaccacea
Rev. bras. farmacogn.. Publicado em: 2017-06
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18. Experimental and Numerical Investigation of the Dynamic Behavior of Clamped Thin Panel Subjected to Underwater Impulsive Loading
Abstract The dynamic response and failure mechanism of clamped thin aluminum alloy plates subjected to underwater impulsive loading are investigated by laboratory experiments and finite element (FE) simulations. The effects of plate thickness, impulsive loading and fluid-structure interaction on failure modes in clamped thin aluminum plates are comprehensive
Lat. Am. j. solids struct.. Publicado em: 2017-06
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19. Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2
Abstract Background Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 (Lys49-PLA2) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA2s is important for these effects; however, the amino acid residues that determine hyperalgesia and e
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 16/03/2017
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20. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme involved in the Trypanosoma cruzi glycolytic pathway, parasite that causes Chagas' disease. There are only few drugs available to treat this disease, most of which present strong side effects. Natural products constitute a prime source for the discovery of new scaffolds potentially useful for t
J. Braz. Chem. Soc.. Publicado em: 2017-03
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21. Assessment of endothelial function by flow-mediated dilation in diabetic patients: Effects of physical exercise
Abstract The endothelium is now recognized as an endocrine organ that acts to maintain vascular homeostasis regulating the vascular tone and structure. The endothelial cells synthetize a variety of mediators among them, the main agent is the nitric oxide (NO), a potent vasodilator. NO exerts its protective role preventing leukocyte adhesion and migration, ex
Motriz: rev. educ. fis.. Publicado em: 2016-03
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22. Statistical evaluation of a novel SSVEP-BCI stimulation setup based on depth-of-field
Abstract Introduction The main drawback of a Brain-computer Interface based on Steady-State Visual Evoked Potential (SSVEP-BCI) that detects the emergence of visual evoked potentials (VEP) in reaction to flickering stimuli is its muscular dependence due to users must redirect their gaze to put the target stimulus in their field of view. In this work, a nove
Res. Biomed. Eng.. Publicado em: 30/10/2015
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23. Effects of age and gender on performance on Conners' Continuous Performance Test in Brazilian adolescents
The present study analyzed the effects of age and gender on performance on the Conners' Continuous Performance Test (CCPT II) in a sample of Brazilian adolescents aged 12-17 years. The sample consisted of 480 participants (210 boys) with a mean age of 14.34 years (SD ± 1.61 years) who were representative of the socioeconomic class distribution of the city o
Psychol. Neurosci.. Publicado em: 2013-06
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24. Facilitatory effects of an auditory warning stimulus in a visual location identification task and a visual shape identification task
The occurrence of a weak auditory warning stimulus increases the speed of the response to a subsequent visual target stimulus that must be identified. This facilitatory effect has been attributed to the temporal expectancy automatically induced by the warning stimulus. It has not been determined whether this results from a modulation of the stimulus identifi
Braz J Med Biol Res. Publicado em: 2012-11