New Human Transcripts
Mostrando 1-12 de 152 artigos, teses e dissertações.
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1. Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
Background: The common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing relevance to human health in developing countries. Although flukicidal drugs are available, re-infection and emerging resistance are demanding new efficient and inexpensive control strategies
Publicado em: 2011
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2. Construção de uma biblioteca de anticorpos recombinantes (FAB) anti-carcinoma mamário e obtenção de fragmentos ligantes de antígenos tumorais por phage display
Breast carcinoma (BC) is currently regarded as a complex and heterogeneous disease presenting abnormalities in several molecular pathways. Although BC is the leading female cancer in incidence and the second one in mortality worldwide, the prognostic and predictive factors known are incapable to predict the outcome of all patients as well as to avoid unneces
Publicado em: 2009
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3. Seqüências ORESTES (open reading frame expressed sequence tags) de trypanosoma cruzi e transcrição de DNA satélite / ORESTES (open reading frame expressed sequence tags) sequences of Trypanosoma cruzi and transcription of satellite DNA
In T. cruzi databases, aproximately 3.750 ESTs of amastigotes and trypomastigotes, sequenced from the 3´ or 5´ ends cDNA clones can be found in T. cruzi databases. The ORESTES (Open Reading Frame Expressed Sequence Tags) methodology generates partial transcribed sequences derived mainly from the central portions of mRNAs, favoring the discovery of new gene
Publicado em: 2008
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4. Interections between CD40/CD40L and PPARs signaling pathways / Interação entre as vias de sinalização CD40/CD40L e os PPARs
The membrane receptor CD40 and its ligand CD40L play an important role in the interface between innate and acquired immunity. Dysfunction of this signaling pathway was described in inflammatory and autoimmune diseases. In systemic lupus erythematosus (SLE), increased serum levels of soluble CD40L have been detected, where it plays a significant role in the g
Publicado em: 2008
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5. Uso de técnicas computacionais no estudo da transcrição e regulação gênica em Homo sapiens e Mus musculus / Use of computational methods to study the transcription and gene regulation in Homo sapiens and Mus musculus
Genes, nucleotide sequences necessary for the synthesis of functional molecules, are transcribed and regulated by extremely complex cellular and molecular processes. To understand when and in which tissues the genes are expressed, their functional isoforms, control regions and the factors involved in gene regulation is one of major challenges of modern molec
Publicado em: 2008
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6. Análise da expressão gênica no dermatófito Trichophyton rubrum mimetizando a infecção in vitro: pH e diferentes fontes de carbono regulando genes / Analysis of gene expression in the dermatophyte Trichophyton rubrum during the mimetic infection in vitro: pH and carboun sources are regulating genes
Dermatophytes are a group of fungi filamentous that have the ability to invade keratinized substrates, causing dermatophytosis in humans and animals and only penetrate deeper if the host is immunocompromised. Trichophyton rubrum is an anthropophilic and cosmopolitan fungi, the most common agent of superficial mycoses, which uses cell components such as prote
Publicado em: 2008
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7. Corpo e Velhice: um estudo da qualidade de vida de idosos da Vila Vicentina Júlia Freire em João Pessoa / Body and old age: a study of the quality of life elderly residents at Vila Vicentina Julia in João Pessoa, Brazil
The aim of this study was to follow the daily routine of elderly individuals residing at the Vila Vicentina Júlia Freire (VVJF) nursing home in João Pessoa, Brazil, observing and analyzing as much as possible, the way in which they live in a group and how they deal, through personal experiences, with their own body image and with that of others. The result
Publicado em: 2008
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8. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008
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9. Implicações funcionais de eventos de splicing alternativo no proteoma humano / Functional implications of alternative splicing in the human proteome
The post-genomic era has emerged as one prosper field to deal with the huge amount of sequences produced by genome projects and increase the understanding of its biological meaning. One of the most surprising mechanisms capable to generate a lot of protein diversity is alternative splicing in immature mRNAs. No more than 22% of the known protein structures e
Publicado em: 2007
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10. Identification and selection of new human genes associated with tumors from the Transcript Finishing Initiative (TFI) Project data. / Identificação e seleção de novos genes humanos associados a tumores a partir de dados obtidos no projeto Transcript Finishing Initiative (TFI)
Após o seqüenciamento completo do genoma humano, a busca e caracterização do conjunto completo de genes humanos constitui-se no principal desafio nesta área de investigação, sendo o passo limitante para o progresso na exploração dos dados contidos no seqüenciamento deste genoma. O projeto de transcriptoma denominado "Transcript Finishing Initiative
Publicado em: 2007
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11. VariaÃÃes transcricionais dos genes AR, SRD5A2, KLK2, PCA3, KLK3 e PSMA e implicaÃÃes no diagnÃstico molecular do cÃncer de prÃstata
CHAPTER I - Prostate cancer is a common disease in the world and in some countries it is one of the main causes of male population mortality. Some molecular markers have been associated with prostate carcinogenesis. To observe changes in transcript levels of the AR, SRD5A2, KLK2, PSMA and PCA3 genes, the mRNA was analyzed in tissues with prostatic adenocarci
Publicado em: 2007
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12. Identificação de um novo Antígeno de Paracoccidioides brasiliensis (Lumazina Sintase) através da Técnica de IVIAT
Paracoccidioides brasiliensis is a thermally dimorphic fungus causing paracoccidioidomycosis (PCM), a mycosis that affects 10 million individuals in Latin America. The infection is acquired by inhaling airborne propagules produced by the fungal mycelium which transforms into the pathogenic yeast form, when at the body temperature. P brasiliensis expresses in
Publicado em: 2006