Neuronal Loss
Mostrando 1-12 de 375 artigos, teses e dissertações.
-
1. Heterozygosity for neuronal ceroid lipofuscinosis predisposes to bipolar disorder
Objective: Bipolar disorder is a heritable chronic mental disorder that causes psychosocial impairment through depressive/manic episodes. Familial transmission of bipolar disorder does not follow simple Mendelian patterns of inheritance. The aim of this study was to describe a large family with 12 members affected by bipolar disorder. Whole-exome sequencing
Brazilian Journal of Psychiatry. Publicado em: 2023
-
2. Physiotherapy for Children with CLN2 Disease
Abstract CLN2 disease (neuronal ceroid lipofuscinosis type 2) is a rare, genetic, paediatric-onset, neurodegenerative lysosomal storage disorder characterised by seizures, ataxia, rapid loss of motor function and language ability, dementia, visual loss and early death. Physiotherapy plays an important role in the management of CLN2 disease, aiming to maintai
J. inborn errors metab. screen.. Publicado em: 04/11/2019
-
3. Hypothermia treatment ameliorated cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients
OBJECTIVES: The inflammatory response is a key mechanism of neuronal damage and loss during acute ischemic stroke. Hypothermia has shown promise as a treatment for ischemic stroke. In this study, we investigated the molecular signaling pathways in ischemic stroke after hypothermia treatment. METHODS: Cyclin-dependent kinase 5 (CDK5) was overexpressed or si
Clinics. Publicado em: 21/10/2019
-
4. Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study
Resumo Justificativa e objetivos A administração intratecal de anti-inflamatórios não esteroides é mais eficaz no tratamento da dor pós-operatória. Anti-inflamatórios não esteroides, como o (S)-(+)-cetoprofeno, pode ser eficaz em doses intratecais inferiores às parenterais. A segurança pré-clínica relativa à possível neurotoxicidade associada
Rev. Bras. Anestesiol.. Publicado em: 10/10/2019
-
5. Multiple uses of fibrin sealant for nervous system treatment following injury and disease
Abstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn furthe
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
-
6. Investigação do efeito neuroprotetor da atorvastatina em um modelo in vitro de toxicidade induzida pelo peptídeo ¿-amiloide
Alzheimer¿s disease is an age-related neurodegenerative disorder characterized by progressive memory loss, inability to perform the activities of daily living and personality changes. AD is characterized histopathologically by the presence of senile plaques, neurofibrillary tangles, synapse loss and neuronal death. Moreover, it is now recognized that neuroi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
7. Reversibilidade parcial de alterações na função cerebral após perda de peso em humanos obesos / Partial reversibility of dysfunctional brain activity following weight loss in obese humans
A obesidade, definida como o acúmulo excessivo ou anormal de gordura que pode causar dano à saúde do indivíduo, é considerada atualmente um dos principais problemas de saúde pública. Ela resulta de um desequilíbrio entre a ingestão alimentar e o gasto de energia. O controle do balanço energético de animais e seres humanos é realizado pelo sistema
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/12/2011
-
8. Correlação entre as espessuras da mácula e da camada de fibras nervosas da retina, medidas pelas tomografias de coerência óptica de dominio Fourier e de domínio do tempo, e a perimetria automatizada na atrofia em banda do nervo óptico / Correlation between macular and retinal nerve fiber layer Fourier domain and time domain optical coherence tomography measurements and visual field loss in band atrophy of the optic nerve
PURPOSE: To investigate the relationship between fourier-domain optical coherence tomography (FD - OCT) measured macular and retinal nerve fiber layer thickness (RNFL) and visual field sensitivity loss on standard automated perimetry in eyes with permanent temporal hemianopia from chiasmal compression and compare the ability of FD - OCT and time-domain optic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/04/2011
-
9. Future developments in brain-machine interface research
Neuroprosthetic devices based on brain-machine interface technology hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurologic diseases and limb loss. During the last decade, considerable progress has been achieved in this multidisciplinary research, mainly in the brain-machine i
Clinics. Publicado em: 2011
-
10. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated Tau protein), along with neu
Clinics. Publicado em: 2011
-
11. Doença do armazenamento lisossomal causada pela ingestão espontânea de Sida carpinifolia em cervos Sambar (Cervus unicolor) cativos no Rio de Janeiro. / Lysosomal storage disease caused by spontaneous ingestion of Sida carpinifolia in captive-Sambar deer (Cervus unicolor) in Rio de Janeiro State, Brazil.
Cases of diseases induced by toxic plants in domestic herbivores are well reported throughout the world and have been studied also in Brazil. However, not much is known about the epidemiological and pathological aspectos of these conditions in free-living wildlife or bred in captivity. The risk for developing the toxicoses in captivity has been increasing, s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/08/2010
-
12. Correlação entre o eletrorretinograma de padrão reverso, a tomografia de coerência óptica e a perimetria automatizada na detecção da perda neural na atrofia em banda do nervo óptico / Relationship between pattern electroretinogram, optical coherence tomography and automated perimetry for detection of neural loss in eyes with band atrophy of the optic nerve
PURPOSE: To evaluate the ability of full-field and hemifield pattern electroretinogram parameters to differentiate between healthy eyes and eyes with band atrophy of the optic nerve and also to evaluate the relationship between pattern electroretinogram amplitude, macular and retinal nerve fiber layer thickness by optical coherence tomography, and visual fie
Publicado em: 2010