Doença do armazenamento lisossomal causada pela ingestão espontânea de Sida carpinifolia em cervos Sambar (Cervus unicolor) cativos no Rio de Janeiro. / Lysosomal storage disease caused by spontaneous ingestion of Sida carpinifolia in captive-Sambar deer (Cervus unicolor) in Rio de Janeiro State, Brazil.

AUTOR(ES)

Bruno Leite dos Anjos

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

17/08/2010

RESUMO

Cases of diseases induced by toxic plants in domestic herbivores are well reported throughout the world and have been studied also in Brazil. However, not much is known about the epidemiological and pathological aspectos of these conditions in free-living wildlife or bred in captivity. The risk for developing the toxicoses in captivity has been increasing, since natural habitats are destroyed by human action, and more centers of wildlife conservation and zoological comes are created. This study describes the epidemiological, biological and clinicopathological, lectin-histochemical and ultrastructural aspects of an outbreak of lysosomal storage disease of oligosaccharides induced by ingestion of Sida carpinifolia in young Sambar deer (Cervus unicolor) in the Rio-Zoo Foundation in the State of Rio de Janeiro, Brazil. Nine deer showed neurological signs characterized by motor and proprioceptive deficits. Then neurological signs were mainly depression, incoordination, dysmetria, ataxia, broad-based members, muscle tremors, loss of tongue tone, frequent falls and death. Grossly hematomas were observed secondary to trauma caused by dominant males of the flock, and whitish striations, especially in the renal cortex. Histologic changes included marked swelling/cytoplasmic vacuolization especially in neurons, progressing to neuronal lysis and axonal spheroids, in exocrine pancreas, thyroid follicular cells and renal tubular epithelial cells. In the lectin-histochemical examination the vacuoles were formed by the accumulation of oligosaccharides specially marked by the lectins WGA, WGA and Con-A. Ultrastructurally, the swelling/vacuolation corresponded to intense cytoplasmic distention of lysosomes, formation of residual bodies or dense granular fragments of membranes and mielinoides bodies. The study has shown the susceptibility of Cervus unicolor to swainsonine by ingestion of S. carpinifolia. Possibly poisoning the animals in this study was conducted by food restriction by the hierarchy among males in the group. It might also determine the marked similarity between clinical and pathological aspects in Sambar deer with the one presented by other herbivores.

ASSUNTO(S)

cervus unicolor doença do armazenamento lisossomal glicoproteínas neuropatologia plantas tóxicas sida carpinifolia medicina veterinaria swainsonina cervus unicolor lysosomal storage disease glycoproteins neuropathology poisoning plants sida carpinifolia swainsonine

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