Nerve Growth Factor Animal
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction
ABSTRACT Purpose: Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury. The aim of this study was to evaluate dipyridamole as a potential treatment agent of post-radical prostatectomy erectile dysfunction. Material and methods: A total of 18 male Sprague-Dawley ra
Int. braz j urol.. Publicado em: 2017-10
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2. Mobilização neural em rato Wistar reverte comportamento e mudanças celulares que caracterizam a dor neuropática. / Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats Wistar.
The Neural Mobilization technique is a noninvasive method that has proved clinically effective in reducing pain sensitivity and consequently in improving quality of life after neuropathic pain. The present study examined the effects of Neural Mobilization (MOB) on pain sensitivity induced by chronic constriction injury (CCI) in rats. The CCI was performed on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012
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3. EFEITO DO FATOR DE CRESCIMENTO DO NERVO (NGF), FATOR DE CRESCIMENTO DE FIBROBLASTO-10 (FGF-10) E INSULINA SOBRE O DESENVOLVIMENTO IN VITRO DE FOLÍCULOS PRÉ-ANTRAIS CAPRINOS / EFFECT OF NERVE GROWTH FACTOR (NGF), FACTOR Fibroblast growth-10 (FGF-10) AND INSULIN ON DEVELOPMENT OF IN VITRO PREANTRAL FOLLICLES GOATS
Os objetivos deste estudo foram: 1) avaliar o efeito da adição de diferentes concentrações do fator de crescimento do nervo (NGF), fator de crescimento de fibroblasto-10 (FGF-10) e insulina na sobrevivência, ativação e crescimento in vitro de folículos pré-antrais caprinos cultivados inclusos em fragmentos de tecido ovariano, e 2) investigar os efei
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/12/2011
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4. Role of sensory nervous system vasoactive peptides in hypertension
The goal of the present research was to elucidate the roles and mechanisms by which the sensory nervous system, through the actions of potent vasodilator neuropeptides, regulates cardiovascular function in both the normal state and in the pathophysiology of hypertension. The animal models of acquired hypertension studied were deoxycorticosterone-salt (DOC-sa
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-09
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5. In vitro assay of biological and chemical toxins using antibodies against lethal toxin neutralizing factor
Lethal Toxin Neutralizing Factor (N-LTNF), MW 63.0 kDa, was isolated from opossum serum. After trypsin digestion, the active domain of N-LTNF was isolated and sequenced. The synthetic peptide consisting of ten amino acids was designated as LT-10. N-LTNF and LT-10 inhibited the lethality of animal, plant and bacteria toxins when tested on mice non-immunologic
Journal of Venomous Animals and Toxins. Publicado em: 2002
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6. Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.
Huntington disease is a dominantly inherited, untreatable neurological disorder featuring a progressive loss of striatal output neurons that results in dyskinesia, cognitive decline, and, ultimately, death. Neurotrophic factors have recently been shown to be protective in several animal models of neurodegenerative disease, raising the possibility that such s
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7. Neurotrophic factors and neurologic disease.
Discovered only 40 years ago, nerve growth factor is the prototypic neurotrophic factor. By binding to specific receptors on certain neurons in the peripheral nervous system and brain, nerve growth factor acts to enhance their survival, differentiation, and maintenance. In recent years, many additional neurotrophic factors have been discovered; some are stru
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8. A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the b
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9. Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.
The importance of nerve growth factor (NGF) for the development of sensory ganglia was investigated by injecting rat fetuses (16.50 days of gestation) with a single dose of anti-NGF antiserum. Four months later the treated animals showed a very large decrease in substance P- and somatostatin-like immunoreactivities in dorsal root ganglia and skin with a less
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10. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
Although immunosuppressant immunophilin ligands promote neurite outgrowth in vitro, their neurotrophic activities are clearly independent of their immunosuppressive activity. In the present report, a novel nonimmunosuppressive immunophilin ligand, GPI-1046 (3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate) is described. I
The National Academy of Sciences of the USA.
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11. Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.
In this study light and EM quantitative analysis were used to examine whether exogenous nerve growth factor (NGF) could affect terminal fields and synaptic connections in the adult rat brain in vivo. Adult rats received, immediately after unilateral decortication, 2.5S NGF (12 micrograms/day) or vehicle intracerebroventricularly for 7 days. Thirty days after
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12. Epidermal growth factor receptor expression in neurofibromatosis type 1–related tumors and NF1 animal models
We have found that EGF-R expression is associated with the development of the Schwann cell–derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack EGF-R and respond to ligands other than EGF. Nevertheless, immunoblotting, Northern analysis, and immunohisto
American Society for Clinical Investigation.