A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.
AUTOR(ES)
Rashid, K
RESUMO
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=40828Documentos Relacionados
- Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
- A longitudinal assessment of seizure outcome and overall benefit from 100 cortectomies for epilepsy.
- Carbamazepine as a single drug in the treatment of epilepsy. A prospective study of serum levels and seizure control.
- Subependymal heterotopia: a distinct neuronal migration disorder associated with epilepsy.
- Nerve growth factor depletion reduces collateral sprouting of cutaneous mechanoreceptive and tooth-pulp axons in ferrets.