Neolignans
Mostrando 13-24 de 24 artigos, teses e dissertações.
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13. Avaliação do efeito tripanocida do eupomatenóide-5 por meio de abordagens de biologia celular e bioquímica : um possível mecanismo de ação
Chagas disease is considered a neglected disease that affects millions of people, but does not have an appropriate and effective treatment. The etiologic agent is the protozoan Trypanosoma cruzi that presents a complex life cycle alternating between a vertebrate host and an invertebrate. In the search for more effective and less toxic drugs, the research for
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2010
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14. Antimycobacterial neolignans isolated from Aristolochia taliscana
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible;
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-02
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15. Synthesis of 8.O.4 neolignans, derivatives and active analogues in Leishmania / Sintese de neolignanas 8.O.4 , derivados e analogos ativos em Leishmania
Neolignans and lignans present significant biological and pharmacological activities. Chemically lignans are dimers derived from the oxidative coupling of cinnamic and/or cinnamyl alcohol, while neolignans derive from allyl and/or propenyl phenols. In this work, the synthesis of neolignans and correlated substances resulted from the condensation reactions be
Publicado em: 2009
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16. Neolignans and sesquiterpenes from leaves and embryogenic cultures of Ocotea Catharinensis (Lauraceae)
Foram isoladas de extratos de folhas de Ocotea catharinensis Mez (Lauraceae) quatorze neolignanas sendo nove benzofurânicas (incluindo três novas substâncias 1e, 2f e 4b), uma secobenzofurânica inédita (3b), duas biciclo[3.2.1]octânicas (incluindo a nova 5c), dois novos dímeros biciclo[3.2.1]octânicos (7a e 7b) e ainda dois sesquiterpenos (incluindo
Journal of the Brazilian Chemical Society. Publicado em: 2009
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17. Chemical ecology of insect and Piperaceae species / Ecologia química de insetos e espécies de Piperaceae
The study was presented in six chapters that included several aspects of chemical ecology of insects and Piperaceae species as following: The Chapter 1 describes taxonomical aspects, natural history of the insects and field observation and the organization of hosts Piperaceae according to the observed feeding preferences of the associated insects. It was obs
Publicado em: 2006
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18. Antifungal activity of the extracts and neolignans from Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck
Extratos de folhas de Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck (Piperaceae), uma planta medicinal utilizada no Brasil para tratar doenças infecciosas, foram testados para a atividade antifúngica sobre as leveduras Candida albicans, C. krusei, C. parapsilosis e C. tropicalis. O extrato em acetato de etila apresentou boa atividade contra
Journal of the Brazilian Chemical Society. Publicado em: 2005-12
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19. Antibacterial activity of extracts and neolignans from Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck
The evaluation of the activity of the aqueous and ethyl acetate extracts of the leaves of Piper regnellii was tested against gram-positive and gram-negative bacteria. The aqueous extractdisplayed a weak activity against Staphylococcus aureus and Bacillus subtilis with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 1000
Memórias do Instituto Oswaldo Cruz. Publicado em: 2003-12
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20. Core electron binding energy (CEBE) shifts applied to structure activity relationship (SAR) analysis of neolignans
O deslocamento da energia de ligação do elétron do caroço (DCEBE) e o CEBE de átomos de carbono, calculados com o método semi-empírico HAM/3, foram utilizados como descritores no estudo das relações estrutura-atividade (SAR) de seis neolignanas. Os resultados obtidos demonstraram a eficiência deste tipo de descritores, nas análises de SAR. Usando-
J. Braz. Chem. Soc.. Publicado em: 2002-11
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21. Relações entre a estrutura quimica de neolignanas e a sua atividade anti-leishmaniose, envolvendo calculos de solvatação
We continue to work on SAR analysis (Structure-Activity Relationships) of neolignans tested against visceral leishmaniasis; we initiated these studies in the middle of 1991. Conformational analysis of a series of 20 neolignans, 11 of which are inactivies and 9 are activies against leishmaniasis, was first performed. Then, phisico-chemical (PC) parameters wer
Publicado em: 1998
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22. Constituintes químicos dos frutos de Iryanthera paraensis Huber / Chemical constituints of Iryanthera paraensis Huber
Os frutos de Iryanthera paraensis Huber foram separados em suas partes constituintes e de seu pericarpo foi obtido o extrato clorofórmico que, por cromatografia e purificação em CLAE, forneceu cinco substâncias inéditas (uma neolignana e quatro γ-butanolidos): Eu-IP: reI (7S,8R)-4-hidroxi-3,5-dimetoxi-Δ1,3,5,1,3,5,7- 7.O.3,8.O.4-neolignana. A-
Publicado em: 1995
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23. Neolignanas e arilpropanoide das folhas de Virola pavonis (A.DC.) A.C. Smith
Virola pavonis is a tree that belongs to the family Myristicaceae natuve to from the Amazon region. From it leaves,crude extracts were obtained in hexane and dichloromethane which after systematic elimination of chlorophylls yelded purified fractions rich in neolignan compounds. The chromatographic separation of these fractions led to the isolation of three
Publicado em: 1988
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24. Sinteses, transformações e estudos espectroscopicos de alguns tipos de neolignanas
Neolignans are natural products of low molecular weight, produced by oxidative coupling of propenilphenol and allylphenol derivatives. Several members of this class of natural products show biological activity, and two of those studied in this thesis, showed activity against the penetration of cercaria of Schistosoma mansoni and against a type af leukemia. S
Publicado em: 1980