Neoadjuvant Therapy
Mostrando 13-24 de 51 artigos, teses e dissertações.
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13. Breast-conserving surgery in locally advanced breast cancer submitted to neoadjuvant chemotherapy. Safety and effectiveness based on ipsilateral breast tumor recurrence and long-term follow-up
OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclita
Clinics. Publicado em: 2017-03
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14. Neoadjuvant chemotherapy with trastuzumab in HER2-positive breast cancer: pathologic complete response rate, predictive and prognostic factors
The purpose of this study was to retrospectively review the pathologic complete response (pCR) rate from patients (n=86) with stage II and III HER2-positive breast cancer treated with neoadjuvant chemotherapy at our institution from 2008 to 2013 and to determine possible predictive and prognostic factors. Immunohistochemistry for hormone receptors and Ki-67
Braz J Med Biol Res. Publicado em: 26/01/2017
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15. Transanal endoscopic operation for rectal cancer after neoadjuvant therapy
PURPOSE: In this paper we report the oncological outcomes from clinical series of patients with rectal cancer submitted to local excision after neoadjuvant therapy and discuss the indications for local excision in partial clinical responders. METHODS: We analysed a prospective database of 39 patients submitted to a transanal endoscopic operation for recta
Acta Cir. Bras.. Publicado em: 2016
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16. Comparison of positive surgical margin rates in high risk prostate cancer: open versus minimally invasive radical prostatectomy
Objective We compared positive surgical margin (PSM) rates for patients with high risk prostate cancer (HRCaP) who underwent open radical retropubic (RRP), robotic (RALP), and laparoscopic (LRP) prostatectomy at a single institution. Materials and Methods We performed a retrospective review of our prospectively maintained IRB approved database identifying
Int. braz j urol.. Publicado em: 2013-09
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17. Avaliação da expressão da proteína EZH2 na resposta do carcinoma de mama localmente avançado à quimioterapia neoadjuvante / EZH2 protein expression on the response to neoadjuvant chemotherapy in locally advanced breast cancer
INTRODUÇÃO: O tratamento de escolha do carcinoma de mama localmente avançado é a quimioterapia neoadjuvante, porém, em virtude da heterogeneidade tumoral, sabe-se que nem todos os tumores responderão a esse tratamento. Neste contexto, avaliamos a proteína EZH2 (Enhancer of Zest Homolog 2), uma histona-metiltransferase catalisadora da trimetilação da
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/10/2012
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18. Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients
The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Arteries were from non-diabetic and type 2 diabetic patients with sigmoid or rectum carcinoma for who
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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19. Radiation therapy and androgen deprivation in the management of high risk prostate cancer
The combined use of radiation therapy (RT) and androgen deprivation for patients with localized high-risk prostate cancer is commonly accepted as the standard treatment among uro-oncologists. Preclinical studies have provided rationale for the use of this combination. Additionally, results of phase 3 studies using conventional doses of RT have supported the
International braz j urol. Publicado em: 2011-04
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20. Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor-C in locally advanced breast cancer patients
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors. OBJECTIVES: We aimed to prospectively assess the expression of Hypoxia inducible factor-1 α and vascular endothelial growth factor-C in locally advanced breast can
Clinics. Publicado em: 2011
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21. Are there differences in zonal distribution and tumor volume of prostate cancer in patients with a positive family history?
PURPOSE: To determine if there are any differences in the zonal distribution and tumor volumes of familial and sporadic prostate cancers (PC) in men undergoing radical prostatectomy. MATERIAL AND METHODS: 839 patients underwent a radical prostatectomy in the absence of prior neoadjuvant therapy between 1987 and 1996. Telephone interviews were conducted to ob
International braz j urol. Publicado em: 2010-10
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22. Sentinel node biopsy in breast cancer: results in a large series
Sentinel lymph node biopsy (SLNB) is an appropriate method for the evaluation of axillary status in cases of early breast cancer. We report our experience in treating cases evaluated using SLNB. We analyzed a total of 1192 cases assessed by means of SLNB from July 1999 to December 2007. SLNB processing was successfully completed in 1154 cases with the use of
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-06
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23. Resultados da associação de braquiterapia de alta taxa de dose à teleterapia no câncer da próstata / Results of the association of high dose-rate brachytherapy with external beam irradiation in prostate cancer
INTRODUCTION: high dose-rate brachytherapy (HDR) for prostate cancer may be a nice treatment option for dose escalation as a boost, when associated to external beam irradiation, mainly if 3D conformal or more advanced technology is not available. PURPOSE: this study analyzes the results and toxicities of HDR brachytherapy boost prior to external beam radioth
Publicado em: 2010
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24. Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with adv
Clinics. Publicado em: 2009-11