Natural Killer Cell
Mostrando 13-24 de 782 artigos, teses e dissertações.
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13. Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region
Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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14. T-Cell Lymphomas in South America and Europe
Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features. As natural killer cells are closely related to T-cells, natural killer-cell lymphomas are also part of the group. The current World Health O
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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15. The role of natural killer cells in chronic myeloid leukemia
Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph). In chronic myeloid leukemia a proliferation of malignant myeloid cells occurs in the bone marrow due to excessive tyrosine kinase activity. In order to maintain homeostasis, natural killer
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
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16. Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the s
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
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17. Estudo de polimorfismos dos genes KIR e HLA em pacientes com câncer de próstata
O câncer de próstata é o segundo câncer mais comum entre homens, uma vez que tanto a incidência como a mortalidade aumentam exponencialmente após a idade de 50 anos. As células Natural Killer (NK) fazem parte do sistema imune inato e reconhecem moléculas de HLA de classe I na célula alvo, através de seus receptores de membrana, chamados killer immu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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18. Avaliação da expressão da granzima b e sua relação com o prognóstico do carcinoma espinocelular de boca / Evaluation of the expression of granzyme b and its relationship with the prognosis of carcinoma of the mouth
Os Linfócitos T Citotóxicos (LTC) e as células Natural Killer (NK) são as células mais efetivas no combate ao câncer, pois essas células reconhecem células tumorais e liberam grânulos citotóxicos ricos em perforina e granzima B (GB). A perforina forma poros nas células tumorais permitindo o influxo da GB. Quando no interior da célula, a GB promov
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/02/2010
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19. Otimização de metodologia para o estudo de genes KIR
Receptores killer cell immunoglobulin-like (KIRs) são moléculas localizadas na superfície de células natural killer (NK) e em subpopulações de linfócitos T codificadas por genes do cromossomo 19q13.4. A interação entre receptores KIR e moléculas antígeno leucocitário humano (HLA) de classe I determina se células NK exercerão ou não sua funçã
Jornal Brasileiro de Patologia e Medicina Laboratorial. Publicado em: 2010-06
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20. Lymphocyte subpopulations during cytomegalovirus disease in renal transplant recipients
We have determined the number of circulating T, B and natural killer cells in renal transplant recipients in order to detect changes during cytomegalovirus (CMV) infections. Serial blood samples were taken from 61 patients on standard triple immunosuppression therapy (cyclosporin A, azathioprine and prednisone). Using two-color flow cytometry analysis, the a
Publicado em: 2010
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21. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
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22. Imunopatologia da dengue: receptores de quimiocinas CC e células iNKT
Dengue virus (DENV), a mosquito-borne flavivirus, is a serious public health problem in many tropical countries. Immune mechanisms involved in the pathogenesis of DENV infection are not fully elucidated. Recent clinical data showed an association between levels of different CC chemokines in plasma and severity of dengue. In this regard, we evaluated the role
Publicado em: 2010
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23. Avaliação da expressão da granzima b e sua relação com o prognóstico do carcinoma espinocelular de boca / Evaluation of the expression of granzyme b and its relationship with the prognosis of carcinoma of the mouth
Os Linfócitos T Citotóxicos (LTC) e as células Natural Killer (NK) são as células mais efetivas no combate ao câncer, pois essas células reconhecem células tumorais e liberam grânulos citotóxicos ricos em perforina e granzima B (GB). A perforina forma poros nas células tumorais permitindo o influxo da GB. Quando no interior da célula, a GB promov
Publicado em: 2010
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24. Circulating natural killer and γδ T cells decrease soon after infection of rhesus macaques with lymphocytic choriomeningitis virus
Rhesus macaques infected with the WE strain of lymphocytic choriomeningitis virus (LCMV-WE) serve as a model for human infection with Lassa fever virus. To identify the earliest events of acute infection, rhesus macaques were monitored immediately after lethal infection for changes in peripheral blood mononuclear cells (PBMCs). Changes in CD3, CD4, CD8 and C
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07