Myogenic Cell
Mostrando 13-24 de 248 artigos, teses e dissertações.
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13. Myogenesis in adult mammalian skeletal muscle in vitro.
An injury to adult mammalian skeletal muscle is followed by regeneration, which involves a process believed to be similar to the differentiation of muscle fibres in the embryo. The origin of these differentiating myogenic cells is conjectural. The aim of the present study was to examine the source of myogenic cells and the process of myogenesis in adult skel
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14. Regulation of Adenylate Kinase and Creatine Kinase Activities in Myogenic Cells
The regulation of the specific activities of adenylate kinase (EC 2.7.4.3) and creatine kinase (EC 2.7.3.2) in myogenic cell lines is independent of cell fusion. The observed increases in enzyme specific activities are cell density dependent, and may be further broken down into contributions from an increase in enzyme activity per cell and a decrease in prot
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15. Tumor cell complementation groups based on myogenic potential: evidence for inactivation of loci required for basic helix-loop-helix protein activity.
Basic helix-loop-helix (bHLH) proteins mediate terminal differentiation in many lineages. By using the bHLH protein MyoD, which can dominantly activate the myogenic differentiation program in numerous cell types, we demonstrated that recessive defects in bHLH protein function are present in human tumor lines. In contrast to prior work with primary cell cultu
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16. Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators.
Activation of muscle gene transcription in differentiating skeletal myoblasts requires their withdrawal from the cell cycle. The effects of ectopic cyclin expression on activation of muscle gene transcription by myogenic basic helix-loop-helix (bHLH) regulators were investigated. Ectopic expression of cyclin D1, but not cyclins A, B1, B2, C, D3, and E, inhib
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17. Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography.
A myogenic growth factor has been purified from a skeletal muscle, the anterior latissimus dorsi, of adult chickens. In the range of 1-10 ng, this factor stimulates DNA synthesis as well as protein and muscle-specific myosin accumulation in myogenic cell cultures. Purification is achieved through binding of the factor to heparin. The factor is distinct from
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18. Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF
Myocyte nuclear factor (MNF) is a winged helix transcription factor that is expressed selectively in myogenic stem cells (satellite cells) of adult animals. Using a gene knockout strategy to generate a functional null allele at the Mnf locus, we observed that mice lacking MNF are viable, but severely runted. Skeletal muscles of Mnf−/− animals are atrophi
The National Academy of Sciences.
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19. Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival
During myogenesis, proliferating myoblasts withdraw from the cell cycle, acquire an apoptosis-resistant phenotype, and differentiate into myotubes. Previous studies indicate that myogenic induction of the cyclin-dependent kinase inhibitor p21 results in an inhibition of apoptotic cell death in addition to its role as a negative cell cycle regulator. Here we
American Society for Microbiology.
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20. Skeletal muscle stem cells
Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between embryonic myogenesis and muscle regeneration. Recent advances have altered the long-standing view of the satel
BioMed Central.
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21. Sox15 Is Required for Skeletal Muscle Regeneration
The Sox genes define a family of transcription factors that play a key role in the determination of cell fate during development. The preferential expression of the Sox15 in the myogenic precursor cells led us to suggest that the Sox15 is involved in the specification of myogenic cell lineages or in the regulation of the fusion of myoblasts to form myotubes
American Society for Microbiology.
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22. ADAM12 and α9β1 Integrin Are Instrumental in Human Myogenic Cell Differentiation
Knowledge on molecular systems involved in myogenic precursor cell (mpc) fusion into myotubes is fragmentary. Previous studies have implicated the a disintegrin and metalloproteinase (ADAM) family in most mammalian cell fusion processes. ADAM12 is likely involved in fusion of murine mpc and human rhabdomyosarcoma cells, but it requires yet unknown molecular
The American Society for Cell Biology.
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23. Effect of cellular determination on oncogenic transformation by chemicals and oncogenes.
Three developmentally determined myogenic cell lines derived from C3H 10T1/2 C18 (10T1/2) mouse embryo cells treated with 5-azacytidine were compared with the parental 10T1/2 line for their susceptibility to oncogenic transformation by 3-methylcholanthrene or the activated human c-Ha-ras oncogene. Neither the 10T1/2 cells nor the myogenic derivatives grew in
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24. The Phenotypic Complexity of Myogenic Clones
A single cell isolated from cultured 8-day leg muscle may, when subcultured, yield a myogenic clone. A myogenic clone consists of myotubes and mononucleated cells. When such a myogenic clone is subcultured, large numbers of mononucleated cells are recovered. These mononucleated cells histologically and biochemically are indistinguishable from authentic fibro