Skeletal muscle stem cells

AUTOR(ES)

Chen, Jennifer CJ

FONTE

BioMed Central

RESUMO

Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between embryonic myogenesis and muscle regeneration. Recent advances have altered the long-standing view of the satellite cell as a committed myogenic stem cell derived directly from the fetal myoblast. The experimental basis for this evolving perspective will be highlighted as will the relationship between the satellite cell and other newly discovered muscle stem cell populations. Finally, advances and prospects for cell-based therapies for muscular dystrophies will be addressed.

Documentos Relacionados

• Hematopoietic potential of stem cells isolated from murine skeletal muscle
• Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
• Human circulating AC133+ stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle
• Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.
• Diffusivity of myoglobin in intact skeletal muscle cells.