Myocardial Fibrosis
Mostrando 13-24 de 114 artigos, teses e dissertações.
-
13. Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
ABSTRACT PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and pr
Acta Cir. Bras.. Publicado em: 2016-03
-
14. Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide
The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood. In this study, we investigated local changes in cardiac aldosterone and its synthase in rats with ISO-induced CHF, and evaluated the effects of treatment with recombinant human brain natriuretic peptide (rhBNP). Sprague-Dawley rats were
Braz J Med Biol Res. Publicado em: 11/07/2014
-
15. A diminuição da perfusão e o dano isquêmico do subendocárdico resultam em disfunção do ventrículo esquerdo na fase aguda da fístula aorto-cava / Low myocardial perfusion and subendocardial ischemia result in left ventricular dysfunction during the acute phase of aortocaval fistula
Recentemente demonstramos o desenvolvimento de fibrose na região subendocárdica (SE) do ventrículo esquerdo (VE) em resposta a sobrecarga de volume na fístula aorto-cava (FAC) crônica. A pressão de perfusão coronariana (PPC) associou-se com fibrose SE e com disfunção do VE subsequentes, sugerindo ser o hipofluxo um dos mecanismos envolvidos no remod
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2011
-
16. Avaliação da fibrose miocárdica pela ressonância magnética e tomografia computadorizada com múltiplos detectores na cardiomiopatia hipertrófica / Myocardial fibrosis evaluation by magnetic resonance and multidetector computed tomography in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder leading cause of sudden death in young people with extremely variable presentation, from asymptomatic to sudden death as first symptom, leads to challenging risk stratification. Recently, both cardiovascular magnetic resonance (CMR) and multidetector computed tomography (MDCT) were able to asses
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2011
-
17. Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occ
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
-
18. A ação do digital na fibrose miocárdica em modelo experimental / Effects of digitoxin on myocardial collagen deposition process in a fibrosis experimental model
Estudos recentes sobre disfunção ventricular demonstram o potencial terapêutico da modulação da matriz extracelular. Isso se dá pela influência que a referida matriz tem sobre a função sistólica e a diastólica do coração. Outros estudos demonstram a influência do digital sobre os sistemas neurohormonais desbalanceados no cenário de disfunção
Publicado em: 2011
-
19. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats
It has been recently shown that calcium channel blockers might have a protective effect on cardiac fibrogenesis induced by aldosterone. The objective of this study was to evaluate the protective effect of felodipine, a dihydropyridine calcium channel blocker, against heart and kidney damage caused by aldosterone-high sodium intake in uninephrectomized rats.
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
-
20. Efeitos da adição de sinvastatina ao enalapril em indivíduos hipertensos com níveis de colesterol limítrofe e disfunção diastólica: um estudo aleatorizado, controlado, duplo-cego, com ecocardiograma e Doppler tecidual de repouso e estresse / Effect of the addition of simvastatin to enalapril in hypertensive individuals with average cholesterol levels and diastolic dysfunction: a randomized, placebo-controlled, double-blind trial, with ecochardiography and tissue Doppler of rest and stres
Background: Diastolic dysfunction (DD) and decreased contractile reserve associated with hypertension are a surrogate for increased cardiovascular risk. Statins have experimental benefits on myocardial fibrosis, and could improve diastolic function or contractile reserve to a greater extend than ACE-inhibitors in hypertension. Objectives: Test in a double-bl
Publicado em: 2010
-
21. Modulação da viabilidade de fibroblastos cardíacos em cultura frente a hipóxia: papel de diferentes concentrações de glicose / Modulation of the viability of cardiac fibroblasts in culture against hypoxia: role of different concentrations of glucose
Estudos mostram que a exposição ao meio hiperglicêmico ou diabetes protege o coração contra insultos patológicos, incluindo isquemia. A ativação de fatores anti-apoptóticos e proliferativos parece estar envolvida com esta cardioproteção. Este estudo foi desenhado para investigar a modulação da viabilidade de fibroblastos cardíacos submetidos à
Publicado em: 2010
-
22. Avaliação da fibrose miocárdica pela ressonância magnética cardíaca na doença valvar aórtica grave: validação de um algoritmo de quantificação e comparação com a histopatologia / Assessment of myocardial fibrosis by cardiac magnetic resonance imaging in severe aortic valve disease: validation of a quantitative algorithm and comparison with histopathology
Introduction: Severe aortic valve disease is characterized by a process of progressive accumulation of interstitial fibrosis in the myocardial tissue. It has been shown that the amount of interstitial myocardial fibrosis can play an important role in the transition from well-compensated hypertrophy to overt heart failure in the setting of chronic left ventri
Publicado em: 2009
-
23. Myocardial fibrosis prevention and accumulation of lipofuscin in myocities cardiac of mdx mice / Prevenção da fibrose miocardica e acumulo de lipofuscina em cardiomiocitos de camundongos mdx
The Duchenne Muscle Dystrophy is a progressive myopathy caused by recessive autossomic disease connected to the gender, which attacks male kids, and involves to motor disability in the property, leading to death around the second decade of life. It is caused by an alteration in the codifier gene of the protein dystropin, which maintains the integrity of the
Publicado em: 2009
-
24. L-arginine administration : the effect on myocardial fibrosis and increase of the carcinogenesis in mice mdx / Administração de L-arginina : efeitos sobre a fibrose miocardica e aumento da carcinogenese em camundongos mdx
The Duchenne Muscle Dystrophy (DMD) is a myopathy characterized by dystrophin absence, which is a structural protein of the plasma membrane. The dystrophin absence leads to functional alterations followed by necrosis in the skeletal and cardiac muscle fiber. As the patients grow older, about 40% of them develop cardiomyopathy due to progressive myocardial fi
Publicado em: 2009