Mutations
Mostrando 37-48 de 24437 artigos, teses e dissertações.
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37. DNA replication stress: oncogenes in the spotlight
Abstract Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromoso
Genet. Mol. Biol.. Publicado em: 13/12/2019
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38. Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model
Abstract The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs) that accumulate due to the homologous recombination deficiency of BRCA-mutated cells. Such accumu
Genet. Mol. Biol.. Publicado em: 13/12/2019
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39. CENÁRIO ECONÔMICO E POLÍTICO MUNDIAL E TENSÕES CONTEMPORÂNEAS NA EDUCAÇÃO: NARRATIVAS E CONCEPÇÕES DE PESQUISADORES NO VI SEMINÁRIO DA EDUCAÇÃO BRASILEIRA
RESUMO: A educação pública tem sido tangenciada, de forma contígua, por graves questões contemporâneas, as quais nos impõem a necessidade de adensar análises sobre as atuais bases societais, as reconfigurações das instituições políticas, as mutações no mundo do trabalho e as apropriações do espaço público. No presente texto, colocaremos em
Educ. Soc.. Publicado em: 09/12/2019
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40. Analysis of drug resistance mutations in pulmonary Mycobacterium tuberculosis isolates in the Southern coastal region of Andhra Pradesh, India
ABSTRACT Purpose and objectives Detection of drug resistance plays a crucial role in tuberculosis (TB) treatment and prevention of Mycobacterium tuberculosis (MTB) transmission. The aim of this study was to determine the levels and patterns of resistance of MTB isolates to two key anti-TB drugs (rifampicin, RIF and isoniazid, INH) and the type of mutations
Braz J Infect Dis. Publicado em: 25/11/2019
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41. Mutational landscape of head and neck squamous cell carcinomas in a South Asian population
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigati
Genet. Mol. Biol.. Publicado em: 14/11/2019
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42. A brief history of the forty-five years of the Epagri apple breeding program in Brazil
Abstract The E’AppleBP is the largest Brazilian apple breeding program in activity in Brazil, with Brazilian and international contributions to breeding of apple cultivars, under public funding. The main objectives are development of new apple cultivars with good local climate adaptation, disease resistance, high yield, high fruit quality, good fruit stora
Crop Breed. Appl. Biotechnol.. Publicado em: 31/10/2019
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43. [PROVISIONAL] Resistance mutations of NS3 and NS5b in treatment-naïve patients infected with Hepatitis C virus in Santa Catarina and Rio Grande do Sul States, Brazil
Abstract Hepatitis C virus (HCV) infection is a worldwide health problem. Nowadays, direct-acting antiviral agents (DAAs) are the main treatment; however, the high level of variability of HCV lead to development of resistance-associated variants (RAVs). Thus, look into the RAVs among infected patients is an important tool for monitoring the efficacy of the t
Genet. Mol. Biol.. Publicado em: 21/10/2019
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44. Class III Malocclusion: Missense Mutations in DUSP6 Gene
Abstract Objective: To determine the DUSP6 gene mutation in three generations of Malaysian Malay subjects having Class III malocclusion. Material and Methods: Genetic analyses of DUSP6 gene were carried out in 30 subjects by selecting three individuals representing three generations, respectively, from ten Malaysian Malay families having Class III malocclu
Pesqui. Bras. Odontopediatria Clín. Integr.. Publicado em: 10/10/2019
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45. MODY probability calculator for GCK and HNF1A screening in a multiethnic background population
ABSTRACT Objective We aimed to identify the frequency of monogenic diabetes, which is poorly studied in multiethnic populations, due to GCK or HNF1A mutations in patients with suggestive clinical characteristics from the Brazilian population, as well as investigate if the MODY probability calculator (MPC) could help patients with their selection. Subjects
Arch. Endocrinol. Metab.. Publicado em: 30/09/2019
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46. Carrier frequency of autosomal recessive disorders (BC, BLAD, FXID and CVM) in Holstein cows in Jalisco, Mexico
ABSTRACT: The hereditary autosomal recessive disorders bovine citrullinemia (BC), bovine leukocyte adhesion deficiency (BLAD), factor XI deficiency (FXID), and complex vertebral malformation (CVM) have affected dairy cattle breeding significantly around the world. This study examined the carrier frequency of BC, BLAD, FXID, and CVM autosomal recessive disord
Pesq. Vet. Bras.. Publicado em: 30/09/2019
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47. How diseases became “genetic”
Resumo O presente artigo tem o objetivo de examinar as origens do termo “doença genética. No final do século XIX e início do XX, a vaga ideia que a doença manifesta entre familiares refletia uma “predisposição” familiar, foi substituída pela visão que essas doenças possuem causas específicas, enquanto a genética mendeliana forneceu as pista
Ciênc. saúde coletiva. Publicado em: 26/09/2019
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48. Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana
BACKGROUND In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES In order to improve vector control it is essential to study mosquito population geneti
Mem. Inst. Oswaldo Cruz. Publicado em: 23/09/2019