Muscle Denervation
Mostrando 13-24 de 172 artigos, teses e dissertações.
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13. Myogenin and MyoD join a family of skeletal muscle genes regulated by electrical activity.
Myogenin and MyoD are proteins that bind to the regulatory regions of a battery of skeletal muscle genes and can activate their transcription during muscle differentiation. We have recently found that both proteins interact with the enhancer of the nicotinic acetylcholine receptor (nAChR) alpha subunit, a gene that is regulated by innervation. This observati
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14. The effects of denervation on contractile properties or rat skeletal muscle.
1. Isometric contractions of fast and slow twitch muscles of rats were recorded 1-42 days after denervation. 2. The major changes occurred over the period from 2 to 6 days after denervation. These changes were qualitatively similar in the two types of muscle. The most important effects were on the twitch: times to peak and half relaxation were prolonged, act
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15. Upstream sequences of the myogenin gene convey responsiveness to skeletal muscle denervation in transgenic mice.
Myogenin, as well as other MyoD-related skeletal muscle-specific transcription factors, regulate a large number of skeletal muscle genes during myogenic differentiation. During later development, innervation suppresses myogenin expression in the fetal hind limb musculature. Denervation of skeletal muscle reverses the effects of the nerve, and results in the
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16. Supersensitivity of the rabbit iris sphincter muscle induced by trigeminal denervation: the role of substance P.
The rabbit left ophthalmic nerve (first branch of the left trigeminal nerve) was cut at the intracranial, peripheral side of the trigeminal ganglion and the effects of denervation were examined using iris sphincter muscle preparations isolated from the left and right eye, as denervated and control innervated preparations, respectively. Electrical transmural
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17. Effect of Muscle Denervation on Growth of Transplanted Tumor in Mice*
A temporary retardation of transplanted Round Cell Neuroblastoma growth in the gastrocnemius muscle of mice was observed in 20% of the animals after denervation of the muscle. The tumor cells in these denervated animals showed structural alterations and deterioration in function. These altered cells when mixed with associated denervated muscle tissue, to whi
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18. Denervated skeletal muscle displays discoordinate regulation for the synthesis of several myofibrillar proteins.
Synthesis patterns of myosin heavy- and light-chain isoforms, tropomyosin and troponin, have been studied in chicken fast muscle denervated at both neonatal and adult stages. Denervated neonatal muscle does not synthesize the adult myosin heavy-chain isoform at the time of denervation, but it does synthesize the adult isoform several months after denervation
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19. Neural regulation of acetylcholine receptors in rat neonatal muscle.
1. The neuronal regulation of the developmental decline in skeletal muscle acetylcholine (ACh) receptors was studied by comparing the effects of sciatic nerve section or of neuromuscular blockade with botulinum toxin (BoTX) on this decline in neonatal and adult rats, using 125I-alpha-bungarotoxin (125I-BTX) as a ligand for the receptor alpha-subunit. 2. The
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20. Regulation of GLUT4 expression in denervated skeletal muscle
Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known about the signaling events that cause this decrease. Experiments were designed to test the hypothesis that decreased GLUT4 expression in denervated muscle occurs because of decreased calcium/CaMK activity, which would then lead to decr
American Physiological Society.
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21. Acetylcholine receptors and sodium channels in denervated and botulinum-toxin-treated adult rat muscle.
1. The number of acetylcholine (ACh) receptors and Na channels was measured in adult rat hind-limb muscles after denervation or injection of botulinum toxin type A (BoTX), using specific binding of radiolabelled neurotoxins. 2. Denervation by sciatic nerve section increased the number of [125I]iodo-alpha-bungarotoxin ([125I]BTX) binding sites from low, unmea
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22. Alterations to mandibular form following motor denervation of the masseter muscle. An experimental study in the rat.
The form of the mandible in young rats was studied following denervation of the masseter muscle. Wistar-derived male rats aged 27 d were randomly assigned either to experimental, sham-operated or control groups. The main trunk and initial branches of the masseteric nerve were resected on one side in each experimental animal. The nerve was exposed, but not re
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23. Type-specific changes in fibre size and satellite cell activation following muscle denervation in two strains of turkey (Meleagris gallopavo).
Morphological features and the chronology of muscle changes after denervation were studied over a 21 d period in 2 heavy (HW) and light-weight (LW) strains of 6-wk-old male turkeys. The atrophy of tibialis cranialis, gastrocnemius lateralis and plantaris muscles was apparent at d 3 after denervation. By d 21 the weight of these muscles had reached 45-60% of
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24. Sodium channel distribution in normal and denervated rodent and snake skeletal muscle.
1. Sodium channel current density was measured using the loose-patch voltage clamp technique. Innervated rat, mouse and snake muscle had the highest density of Na+ channels in the end-plate region. These high Na+ channel densities were maintained in denervated muscle. 2. Perijunctional membrane had a Na+ current density 5- to 10-fold greater than the density