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Mostrando 1-12 de 22255 artigos, teses e dissertações.
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1. Qual a diferença do Oseltamivir em relação aos antivirais usados para tratamento de Herpes e HIV? Qual o mecanismo de ação de cada um deles?
O Oseltamivir, classificado como inibidor da liberação da desmontagem viral, é um antiviral que inibe de forma seletiva a enzima neuroaminidase específica do vírus influenza, que é essencial para a entrada e liberação desse vírus nas células humanas. Desta forma, o oseltamivir, administrado por via oral, inibe a replicação dos vírus influenza
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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2. Oxidative Stress and Changes of Important Metabolic Gene Expressions as a Potential Biomarker in the Diagnosis of Atherosclerosis in Leukocytes
ABSTRACT Introduction: Presenilin 1 (PSEN1), catalase (CAT), glutathione-S-transferase (GST) and paraoxonase 1 (PON1) play a vital role in prediction, diagnosis and therapy of metabolic disorders. Methods: Metabolic enzyme activities and lipid peroxidation in serum of cerebrovascular diseases (CVD) and coronary artery diseases were measured by spectrophoto
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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3. Miocardite Aguda após a Vacina de mRNA contra a COVID-19
Arquivos Brasileiros de Cardiologia. Publicado em: 2022
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4. Miocardite Aguda após Vacina de mRNA contra a COVID-19: Uma Correspondência
Arquivos Brasileiros de Cardiologia. Publicado em: 2022
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5. Comparison of the effects of corneal and lacrimal gland denervation on the lacrimal functional unit of rats
RESUMO Objetivo: O nosso objetivo neste estudo foi comparar as alterações na unidade funcional lacrimal em dois modelos de síndrome do olho seco neurogênica: desnervação sensorial da córnea versus desnervação autonômica da glândula lacrimal. Métodos: A rede neural é um importante suporte para a unidade funcional lacrimal. Pode ser dividido em
Arquivos Brasileiros de Oftalmologia. Publicado em: 2022
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6. The circadian timing of noise exposure influences noise-induced inflammatory responses in the mouse cochlea
Abstract Introduction: Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss. Nevertheless, the mechanisms of noise-induced hearing loss are still not fully understood. Objective: To investigate the dynamics of inflammatory responses in the mammalian cochlea following noise trauma at two different times, once during the l
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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7. Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I
SUMMARY OBJECTIVE: Heart attack is one of the most common causes of sudden death in adults. Therefore, early detection of heart attack and investigation of potential new biomarkers are of great importance. We investigated whether perilipin-5 is a potential biomarker by examining changes in perilipin-5 serum levels along with high-sensitivity cardiac troponi
Revista da Associação Médica Brasileira. Publicado em: 2022
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8. Evaluation of the Rho-kinase gene expression and polymorphisms in adult patients with acute appendicitis: a differential impact of gender
SUMMARY OBJECTIVE: Acute appendicitis represents one of the most common causes of acute intra-abdominal emergencies worldwide. In this case-control study, we aimed to investigate associations of Rho-kinase gene expression and polymorphisms with acute appendicitis in a Turkish population. We also aimed to study the effects of gender on these parameters. MET
Revista da Associação Médica Brasileira. Publicado em: 2022
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9. Gene Silencing Therapeutics in Cardiology: A Review Article
Abstract Therapeutics that inhibit enzymes, receptors, ion channels, and cotransporters have long been the mainstay of cardiovascular medicine. Now, oligonucleotide therapeutics offer a modern variation on this paradigm of protein inhibition. Rather than target a protein, however, small interfering ribonucleic acids and antisense oligonucleotides target the
International Journal of Cardiovascular Sciences. Publicado em: 2022
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10. SATELLITE CELL ACTIVATION AND SIGNALING PATHWAY RESPONSE IN JOINT EXERCISE ATHLETES
RESUMO Introdução: As células satélites musculares esqueléticas são consideradas a única fonte de células-tronco para a diferenciação miogênica das células musculares esqueléticas adultas. Após a estimulação, a célula satélite muscular esquelética pode ser ativada através de vias de sinalização específicas, proliferar e diferenciar-se
Revista Brasileira de Medicina do Esporte. Publicado em: 2022
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11. EFFECT OF MERCURY EXPOSURE ON U1-70 KDA PROTEIN EXPRESSION IN EMBRYOS OF BLACK BEAN (Phaseolus vulgaris L.)
Exposure to heavy metals has been documented to induce changes in the expression of plant proteins. Phaseolus vulgaris L., represents a great source of nutrition for millions of people, and is the second most important legume crop. The present study aimed to investigate the effects of Hg stress on germination rate and identify the gene expression profiling o
Química Nova. Publicado em: 2022
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12. Expansion of cord blood stem cells in fibronectin-coated microfluidic bioreactor
ABSTRACT Background: Hematopoietic stem/progenitor cell transplantation is the main treatment option for hematological malignancies and disorders. One strategy to solve the problem of low stem cell doses used in transplantation is pre-transplant expansion. We hypothesized that using fibronectin-coated microfluidic channels would expand HSPCs and keep self-r
Hematology, Transfusion and Cell Therapy. Publicado em: 2022