Molecular Motors
Mostrando 1-12 de 89 artigos, teses e dissertações.
-
1. Desenvolvimento de vetores não virais para entrega gênica baseados na cadeia leve de dineína Rp3 = : Development of non viral vectors for gene delivery based on dynein light chain Rp3 / Development of non viral vectors for gene delivery based on dynein light chain Rp3
Gene delivery is a promising technique with great medical potential that consists in the introduction of exogenous nucleic acids, and can be applied for gene therapy as well as DNA vaccination. However, its use is still limited by the lack of an ideal delivery vector, which is both safe and efficient. Although much more effective, viral vectors still raise s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/07/2012
-
2. Asymetric exclusion model for intracellular transport driven by molecular motors / Um modelo de exclusão assimétrico para o transporte de partículas mediado por motores moleculares
Motores moleculares são proteínas capazes de transportar objetos tais como vesículas, organelas e macromoléculas ao longo do citoesqueleto. Tratam-se de dispositivos bastante interessantes do ponto de vista físico, pois produzem trabalho em um ambiente extremamente ruidoso. Recentemente, diversos experimentos realizados in vivo têm revelado que objetos
Publicado em: 2008
-
3. Movimento bidirecional no transporte intracelular mediado por motores moleculares / Bidirectional movement in the intracellular transport mediated by molecular motors
In this work we present a theoretical model to describe aspects of the bidirectional movement performed by intracellular structures (vesicles, organelles, viruses etc, to which we refer here simply as "vesicles"), observed essentially at in vivo experiments. This nondifusive movement is characterized by rapid inversions in direction and is capable of creatin
Publicado em: 2007
-
4. Brownian ratchets and the photoalignment of liquid crystals
Molecular motors play key roles in areas ranging from biological transport to emerging nanotechnology. They produce current as a result of transfer of energy but not of momentum from a source; many molecular motor scenarios are based on the translational Brownian ratchet mechanism. Here we consider the mechanism of photoalignment of liquid crystals both in t
Brazilian Journal of Physics. Publicado em: 2002-06
-
5. Oclusor ativo implantavel para colostomias : prototipo
: Aiming to improve the quality of life of colostomates, the prototype of na Active Implantable Colostomy Occluder was built. The fundamental idea is to reproduce the natural sphincter?s action by using a construction band placed around the stoma and pulled by a step motor. The active element of the prototype is a step motor and its torque is powered by thre
Publicado em: 1997
-
6. Molecular motors: thermodynamics and the random walk.
The biochemical cycle of a molecular motor provides the essential link between its thermodynamics and kinetics. The thermodynamics of the cycle determine the motor's ability to perform mechanical work, whilst the kinetics of the cycle govern its stochastic behaviour. We concentrate here on tightly coupled, processive molecular motors, such as kinesin and myo
-
7. Cooperative extraction of membrane nanotubes by molecular motors
In eukaryotic cells, nanotubes represent a substantial fraction of transport intermediates between organelles. They are extracted from membranes by molecular motors walking along microtubules. We previously showed that kinesins fixed on giant unilamellar vesicles in contact with microtubules are sufficient to form nanotubes in vitro. Motors were attached to
National Academy of Sciences.
-
8. The Neurospora organelle motor: a distant relative of conventional kinesin with unconventional properties.
The "conventional" kinesins comprise a conserved family of molecular motors for organelle transport that have been identified in various animal species. Organelle motors from other phyla have not yet been analyzed at the molecular level. Here we report the identification, biochemical and immunological characterization, and molecular cloning of a cytoplasmic
-
9. A minimal system allowing tubulation with molecular motors pulling on giant liposomes
The elucidation of physical and molecular mechanisms by which a membrane tube is generated from a membrane reservoir is central to the understanding of the structure and dynamics of intracellular organelles and of transport intermediates in eukaryotic cells. Compelling evidence exists that molecular motors of the dynein and kinesin families are involved in t
National Academy of Sciences.
-
10. Unidirectional rotary motion in a liquid crystalline environment: Color tuning by a molecular motor
Life could not exist without motion induced by a variety of molecular motors. The construction of artificial motors by chemical synthesis, which can power motions that lead to macroscopic detectable effects in a system, is a major endeavor in contemporary science. To move toward this goal, a host–guest system, composed of a nematic liquid crystal film dope
National Academy of Sciences.
-
11. Bidirectional cooperative motion of molecular motors
Recently, in a beautiful set of experiments, it has been shown that a Ncd mutant, NK11, which lacks directionality in its individual motion, was able to exhibit a new kind of directed motion in motility assays (Endow, S. A. & Higuchi, H. (2000) Nature (London) 406, 913–916): the filaments keep a given velocity for a while and then suddenly move in the oppo
The National Academy of Sciences.
-
12. Rotary DNA motors.
Many molecular motors move unidirectionally along a DNA strand powered by nucleotide hydrolysis. These motors are multimeric ATPases with more than one hydrolysis site. We present here a model for how these motors generate the requisite force to process along their DNA track. This novel mechanism for force generation is based on a fluctuating electrostatic f