Molecular Biomarker
Mostrando 13-24 de 46 artigos, teses e dissertações.
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13. Estudo qualitativo e quantitativo de biomarcadores ácidos e hidrocarbonetos presentes em óleos da Bacia Potiguar / Qualitative and quantitative study of acidic and hydrocarbon biomarkers of oil from the Potiguar Basin
rabalho foram sintetizados quatro biomarcadores ácidos, a saber: ácido 5b (H) colânico (2), 5a (H) homopregnânico (4), 8,13-tetraidrocopálico (6) e 15-isocopálico (7). Para tanto, foram utilizadas matérias primas comerciais (ácido litocólico e estigmasterol) e o ácido copálico (extraído e purificado a partir de bálsamo de copaíba). Também foi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/12/2011
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14. Papel de TGFβ-1 na regulação da expressão de MMPs seus inibidores (TIMPs e Reck) em modelo de carcinoma mamário humano: análise funcional de RECK e sua correlação com dados clínico-patológicos / Role of TGFβ-1 as a common regulator of MMPs and their inhibitors (TIMPs e RECK) in human breast cancer cell model: functional analysis of RECK and its correlation with clinical-pathological
The metastatic disease is the main mortality cause of breast cancer patients. The metastatic process involves a complex cascade of events, including the organized breakdown of the extracellular matrix (ECM) compounds. The degradation of ECM is tightly regulated by the balance between the activities of matrix metalloproteinases (MMPs) and their inhibitors, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/10/2011
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15. Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil
A mutation described as a G-to-A transition has been reported in SDF-1 gene (SDF1-3'A), being prevalent in all ethnic groups, except in Africans. This mutation is associated with the onset of AIDS progression. Our aim was to identify the frequency of this allele in different groups from Brazil: Tiriyó and Waiampi Amerindian tribes (Asian ancestry); selected
Brazilian Journal of Infectious Diseases. Publicado em: 2010-04
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16. Toxic Effects of Benzo(a)pyrene on the Red Macroalga Gracilaria birdiae / Efeitos tóxicos de benzo(a)pireno sobre a macroalga vermelha Gracilaria birdiae
Algae show a great biodiversity and occupy many different ecological niches. Besides being essential for the maintenance that allow life on Earth, algae are on the basis of aquatic food chains and they suffer with continuous residue discharge that comes from different human activities. However, once algae are exposed to pollutants, biomarkers can indicate it
Publicado em: 2010
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17. Aerobic and anaerobic biodegradation of petroleum from Pampo Sul Field, Campos Basin, RJ, Brazil / Biodegradação aerobia e anaerobia de petroleo do Campo Pampo Sul, Bacia de Campos, RJ
The main purpose of this thesis was the simulation of petroleum biodegradation processes under reservoir aerobic, anaerobic or mixed conditions. The biodegradation experiments were first adapted to the laboratory scale in order to simulate different reservoir conditions taking care to select the best parameters to accelerate million times the biodegradation
Publicado em: 2009
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18. Estudos ecogenômicos e bioprospectivos de Shewanella ssp
Bacteria trom Shewanella and Geobacter ganera are the most studied iron-reducing microorganisms particularly due to their electron transport systems and contribution to some industrial and environmental problems, including steel corrosion, bioenergy and bioremediation of petroleum-impacted sites. The present study was focused in two ways: the first is an in
Publicado em: 2009
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19. Caracterización y clasificación geoquímica de asfaltitas cubanas
Traditional biomarker parameters and aromatic compounds were applied to characterize and classify ten Cuban asphaltites (asphaltene-rich petroleum occurring as seeps or filling veins, joints, cavities and fissures). Genetic molecular parameters were compared in order to establish oil-oil correlations between samples. Thermal evolution was investigated using
Química Nova. Publicado em: 2008
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20. Extraction of amyloid precursor protein isoforms from blood plasma´s platelet for proteomic tests as Alzheimer disease biomarker / Extração das isoformas da proteína precursora do amilóide em plasma rico em plaquetas para testes proteômicos como biomarcador da doença de Alzheimer
Este trabalho de mestrado teve como objetivo o desenvolvimento de uma metodologia analítica focada no preparo de amostra protéica. O objeto de estudo foram os fragmentos solúveis das isoformas da proteína precursora do amilóide (APPs) presentes no plasma rico em plaquetas. As APPs têm sido amplamente estudadas em diversos grupos de pesquisa no Brasil e
Publicado em: 2008
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21. Protocolo para avaliaÃÃo da expressÃo gene ABL sob estresse radioativo
As crescentes aplicaÃÃes das radiaÃÃes ionizantes, associadas à evoluÃÃo das tÃcnicas de anÃlises moleculares, tÃm despertado grande interesse para identificaÃÃo de marcadores moleculares de irradiaÃÃo ocupacional ou acidental. Alguns genes envolvidos na resposta molecular ao estresse radioativo foram identificados pela alteraÃÃo de sua capac
Publicado em: 2008
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22. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008
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23. Estudos in silico da proteína AlkB e prospecção de bactérias alcanotróficas em solos da bacia petrolífera potiguar
Some microorganisms from virgin ecosystems are able to use petroleum it as source of carbon and energy. The knowledge of microbial biodiversity can help to reveal new metabolic systems for utilization alkanes with biotechnological importance. The aim of this study is: i) Accomplish an in silico study of the AlkB protein aimed to understand the probable mecha
Publicado em: 2007
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24. Differential expression of the KLK2 and KLK3 genes in peripheral blood and tissues of patients with prostate cancer
We used the multiplex semi-quantitative reverse-transcriptase PCR (RT-PCR) to investigate kallikrein 2 and 3 (KLK2 and KLK3) mRNA levels in prostate tissue from 42 prostate cancer patients, 33 of whom were also assessed for peripheral blood KLK2 expression by qualitative semi-nested RT-PCR. We found that KLK2 was an important tissue biomarker for distinguish
Genetics and Molecular Biology. Publicado em: 2006