Microsatellite Instability
Mostrando 1-12 de 120 artigos, teses e dissertações.
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1. The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder
SUMMARY OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinoma seen in patients under 40 years of age and tumor micr
Rev. Assoc. Med. Bras.. Publicado em: 2021-01
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2. Mechanisms and biomarker candidates in pterygium development
RESUMO A patogênese do pterígio tem sido relacionada, prin cipalmente, à exposição à luz ultravioleta, mas esta asso ciação permanece bastante controversa. O mecanismo completo do pte rígio também permanece por esclarecer. Fatores como inflamação, infecção viral, estresse oxidativo, metilação do DNA, mediadores inflamatórios, moduladores de
Arq. Bras. Oftalmol.. Publicado em: 30/09/2019
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3. Repetitive DNAs and shrink genomes: A chromosomal analysis in nine Columbidae species (Aves, Columbiformes)
Abstract An extensive karyotype variation is found among species belonging to the Columbidae family of birds (Columbiformes), both in diploid number and chromosomal morphology. Although clusters of repetitive DNA sequences play an important role in chromosomal instability, and therefore in chromosomal rearrangements, little is known about their distribution
Genet. Mol. Biol.. Publicado em: 19/02/2018
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4. Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease?
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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5. Costs of genetic testing: Supporting Brazilian Public Policies for the incorporating of molecular diagnostic technologies
This study identifies and describes the operating costs associated with the molecular diagnosis of diseases, such as hereditary cancer. To approximate the costs associated with these tests, data informed by Standard Operating Procedures for various techniques was collected from hospital software and a survey of market prices. Costs were established for four
Genet. Mol. Biol.. Publicado em: 2015-09
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6. Genomic instability in human actinic keratosis and squamous cell carcinoma
OBJECTIVE: To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. INTRODUCTION: Cancer cells are prone to genomic instability, which is often due to DNA polymerase slippage during the replication of repetitive DNA and to mutations i
Clinics. Publicado em: 2011
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7. Leucoplasias bucais: estudo comparativo entre o grau histológico de displasia, imunoexpressão de hMLH1 e p53 e análise quantitativa de AgNOR
hMLH1 is a protein of the mammalian mismatch repair system (MMR), which maintains genomic stability during repeated duplication. Investigations point to a role of hMLH1 in oral carcinogenesis, and its expression pattern may be related to epigenetic events and microsatellite instability in oral leukoplakias and squamous cell carcinomas. It seems that those al
Publicado em: 2010
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8. Obtaining molecular markers for prognostic and diagnosis of cutaneous malignant melanoma. / Obtenção de marcadores moleculares para prognóstico e diagnóstico de melanoma cutâneo maligno.
The incidence of malignant skin melanoma (MM) increases around 2,5 a 4% each year in the world. The main risk factors are family history of MM, multiple benign or atypical nevi, and additional factors such as immunossuppression, sun sensibility and UV exposure. Genomic instability is responsible for a collection of mutations that are frequently involved in m
Publicado em: 2009
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9. Assessing the Molecular and Genetic Aspects of Squamous Cell Carcinoma of the Larynx / Avaliação Genético-Molecular do Carcinoma das Células Escamosas da Laringe
The larynx is a structure of the upper aerodigestive tract responsible for the production of sounds as well as protecting the lower airways and helping during the normal act of swallowing. Any pathology which affects the larynx can impose several challenges that disrupt its normal physiological function, and consequently and directly resulting in reduction o
Publicado em: 2009
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10. A instabilidade genômica como fator prognóstico e diagnóstico na progressão de queratose actínica para carcinoma espinocelular humano / Genomic instability as a prognostic and diagnostic factor on the progression of human actinic keratosis, to squamous cell carcinoma
Genomic instability has been widely used to characterize cancer cells. Genetic alterations in human actinic keratosis (AK) and squamous cell carcinomas (SCC) were investigated by the random amplified polymorphic DNA (RAPD) method, and microsatellite analysis. DNA was obtained from Brazilian patients diagnosed and treated in the School of Medicine of Universi
Publicado em: 2007
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11. Polymorphic variation of mononucleotide microsatellites and its implication for microsatellite instability screening
Publicado em: 2007
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12. Instabilidade de microssatélites em carcinoma colorretal de pacientes jovens por técnicas de biologia molecular em amostras processadas rotineiramente para diagnóstico anátomo-patológico
Introduction: Colorectal cancer (CCR) is the second most common neoplasia in the developing countries, after lung cancer in men and breast cancer in women. Microsatellites are repetitive short sequences of nucleotides in all human being genome, susceptible to enlarged or contract itself during DNA replication. Tumors that present deficiency in DNA repair gen
Publicado em: 2007