Microsatellite Instability
Mostrando 13-24 de 120 artigos, teses e dissertações.
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13. Intrinsic structural variation of the complex microsatellite marker MYCL1 in Finnish and Somali populations and its relevance to gastrointestinal tumors
The structurally complex MYCL1 microsatellite marker is often used to determine microsatellite instability in colorectal cancers but the allelic variation of this marker has remained largely uncharacterized in both populations and in cancers. Our study describes the allelic distributions of MYCL1 in Finnish (n = 117) and Somali population samples (n = 61) of
Genetics and Molecular Biology. Publicado em: 2006
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14. "Estudo das alterações dos microssatélites D6S251 e D6S252 no carcinoma basocelular esporádico" / Study of alterations in microsatellites D6S251 and D6S252 in sporadic basal cell carcinoma
Existe grande interesse na determinação das bases genéticas do carcinoma basocelular (CBC) que expliquem seu fenótipo pouco agressivo e comportamento metastático infreqüente. Investigamos a instabilidade de microssatélites (MSI) e perda de heterozigosidade (LOH) nos microssatélites D6S251 (6q14) e D6S252 (6q16) de CBCs esporádicos de alto e baixo ri
Publicado em: 2006
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15. Low doses of gamma ionizing radiation increase hprt mutant frequencies of TK6 cells without triggering the mutator phenotype pathway
The TK6 lymphoblastoid cell line is known to be mismatch repair (MMR) and p53 proficient. Deficiency in MMR results in a mutator phenotype characterized by microsatellite instability (MSI) and increased hprt mutant frequency (MF). Increased hprt MF is also a biomarker of effect for exposure to ionizing radiation. In order to test if a mutator phenotype could
Genetics and Molecular Biology. Publicado em: 2006
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16. Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes. Expansion and contraction of microsatellite sequences due to a deficient mismatch repair system are a marker of the mutator phenotype. Controversial results r
Genetics and Molecular Biology. Publicado em: 2004
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17. Efeito da seleÃÃo natural em alelos microssatÃlites (SSR) do feijoeiro e associaÃÃo com QTLs de caracteres agronÃmicos / Effect of natural selection on common bean SSR alleles and their association with agronomical QTLs.
The objectives of this study were to identify microsatellite (SSR) markers selected by natural selection, and their association with QTLs for grain yield, angular leaf spot reaction and 100 seed weight, in common bean (Phaseolus vulgaris) segreganting populations. One hundred and seven families from the F8 generation and 107 from the F24, derived from the Ca
Publicado em: 2004
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18. Microsatellite instability and cytogenetic survey in myeloid leukemias
Microsatellites are short tandem repeat sequences dispersed throughout the genome. Their instability at multiple genetic loci may result from mismatch repair errors and it occurs in hereditary nonpolyposis colorectal cancer. This instability is also found in many sporadic cancers. In order to evaluate the importance of this process in myeloid leukemias, we s
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-02
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19. Detection of microsatellite instability but not truncating APC mutations in gastric adenocarcinomas in Brazilian patients
Um papel crucial para o gene da polipose cólica adenomatosa (APC) na carcinogênese colo-retal já está estabelecido, mas sua participação nos tumores gástricos permanece controversa. Mutações no APC foram detectadas com uma freqüência relativamente alta em tumores gástricos em pacientes japoneses, mas tais mutações foram relatadas como sendo mui
Genetics and Molecular Biology. Publicado em: 2000-06
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20. Analysis of the frequency of microsatellite instability and p53 gene mutation in splenic marginal zone and MALT lymphomas.
AIMS: Studies of the genetic characteristics of splenic marginal zone lymphoma (SMZL) have failed to identify genetic changes specific to this tumour. Microsatellite instability is a type of genomic instability associated with different types of human cancer. Although microsatellite instability is rare in B cell non-Hodgkin's lymphomas, it has been found in
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21. Precise assessment of microsatellite instability using high resolution fluorescent microsatellite analysis.
The instability of microsatellite sequences dispersed in the genome has been linked to a deficiency in cellular mismatch repair. This phenotype has been frequently observed in various human neoplasms and is regarded as a major factor in tumorigenesis. To demonstrate alterations in microsatellite sequences, polymerase chain reaction (PCR) and electrophoretic
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22. Allelic imbalance and microsatellite instability of the DCC gene in colorectal cancer in patients under the age of 35 using fluorescent DNA technology.
AIM: To assess allelic imbalance and microsatellite instability in the region of the "deleted in colorectal cancer" (DCC) gene on chromosome 18q using fluorescent DNA technology in colorectal cancer in patients under the age of 35. METHODS: Thirty two cases of colorectal cancer in patients under the age of 35 and with no family history of colon cancer were r
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23. Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers.
AIM: To investigate the presence of genetic instability in precancerous lesions of the stomach. METHODS: Fifteen cases of sporadic gastric cancers with a background of intestinal metaplasia were studied by microsatellite assay at nine loci. Altered metaplastic mucosa was microdissected, reconstructed topographically, and examined immunohistochemically with a
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24. The role of SOS and flap processing in microsatellite instability in Escherichia coli
Mutations affecting mismatch repair result in elevated frequencies of microsatellite length alteration in prokaryotes and eukaryotes. However, the finding that microsatellite instability is found often in cells with a functional mismatch repair system prompted a search for other factors of tract alteration. In the present report, we show that, in Escherichia
The National Academy of Sciences.