Metalloproteins
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Synthesis, Antileishmanial Activity and Spin Labeling EPR Studies of Novel β-Carboline-Oxazoline and β-Carboline-Dihydrooxazine Derivatives
A series of novel 1-(substituted-phenyl)-3-(4,5-dihydro-1,3-oxazol-2-yl)-9H-β-carboline (8a-8i) and 1-(substituted-phenyl)-3-(5,6-dihydro-4H-1,3-oxazin-2-yl)-9H-β-carboline (9a-9h) derivatives, as well as their respective N-(chloroalkyl)-1-(substituted-phenyl)-9H-β-carboline-3-carboxamide precursors (6a-6i and 7a-7h), were synthesized and evaluated for th
J. Braz. Chem. Soc.. Publicado em: 2020-06
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2. Effects of Iron Enrichment of Adzuki Bean (Vigna angularis) Sprouts on Elemental Translocation, Concentrations of Proteins, Distribution of Fe-Metalloproteins, and Fe Bioaccessibility
Iron (Fe) is an essential element for human nutrition, and its deficiency or low hemoglobin levels are a global health issue. Strategies aimed at increasing the amounts of essential elementals in agricultural products, as sprouts of adzuki bean (Vigna angularis), can be a way to minimize deficiencies, mainly in the populations of developing countries. Theref
J. Braz. Chem. Soc.. Publicado em: 2017-10
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3. Relação de MMPs, TIMP-2 e organização do colágeno com a força de resistência do ligamento periodontal ao movimento eruptivo em incisivos de ratos / MMPs, TIMP-2 and collagen organization relation with the strength of resistance that the PL offers to the eruptive in rat incisors
O ligamento periodontal (LP) é um tecido conjuntivo que ocupa o espaço entre o dente e seu alvéolo, e tem a função principal de ancoragem e suporte dos dentes. Baseados em dados na literatura que mostram que dentes em hipofunção são mais facilmente extraídos, investigamos qual(is) fatores e/ou moléculas poderiam ter relação com esse enfraquecimen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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4. Characterization of proteolityc, hemorrhagic and edematogenic activities of BmHF-1 metallproteinase, isolet from Bothrops marajoensis crude venom / Caracterização das atividades proteolitica, hemorragica e edematogenica de uma metaloprotease BmHF-1 isolada a partir do veneno total de Bothrops marajoensis
In this present work we described the isolation, structural and functional characterization of a new metalloproteinase, named BmHF-1. This protein was isolated with a high degree of purity from the Bothrops marajoensis snake venom by the combination of two chromatographic steps, size exclusion in a Superdex G-75 column coupled to HPLC biocompatible system, f
Publicado em: 2009
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5. Avaliação comparativa de procedimentos de extração de proteinas em plantas medicinais e fitoterapicos e quantificação de metais associados a essas proteinas / Comparative evaluation of protein extraction procedures in medicinal plants and phytomed and quantitation of associated metals to these proteins
This work presents the evaluation of eleven protein extraction procedures using ginkgo biloba (Ginkgo biloba L.), horse chestnut (Aesculus hippocastanum) medicinal plants, and also using the phytomedicine Spirulina (Spirulina maxima). The procedures varied since the agitation only until the addition of several steps, such as agitation, maceration, sonication
Publicado em: 2008
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6. Effect of PTH administration on the IL-1beta, IL-6, TNF-alfa, MMP-2, MMP-9 and TRAP expression in the periodontal tissues of rats with experimental periodontitis / Avaliação do efeito do PTH nas citocinas IL-1beta, IL-6, TNF-alfa, nas metaloproteinases da matriz 2 e 9, e na atividade osteoclastica em ratos com periodontite induzida
Intermittent Parathyroid hormone (PTH) administration has been used as an anabolic agent, and when it is administrated in rats with induced periodontitis, it is able to decrease alveolar bone loss, and reduce the inflammatory cells on the marginal gingival tissue. A possible action of the PTH in cytokines and metalloproteinase (MMPs), related with breakdown
Publicado em: 2007
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7. A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism / Participação da metaloproteinase 9 da matriz extracelular nas alterações hemodinamicas apos embolia pulmonar aguda
Metaloproteinases modulam a contratilidade vascular e podem afetar a hipertensão pulmonar que ocorre na embolia pulmonar induzida (EPA). Nós examinamos os efeitos da administração de doxiciclina ( um inibidor das metaloproteinases) em cães anestesiados e submetidos à EPA. Métodos: 5 cães no grupo sham receberam somente salina. EPA foi induzida por in
Publicado em: 2007
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8. Evaluation of protein and metalloprotein changes in soybean seed after genetic modification process / Avaliação das alterações proteicas e metaloproteicas em soja apos o processo de modificação genetica
This research work consisted of comparison of two kinds of soybeans [Glycine max (L.) Merrill], transgenic and non-transgenic, using proteomics and metalloproteomics changes. Firstly, soybeans proteins were extracted with an extraction buffer containing Tris-HCI (pH 8.8), KCI, DTT, PMSF and SDS, and then they were quantified by the Bradford method. In terms
Publicado em: 2007
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9. Electron-transfer functionality of synthetic coiled-coil metalloproteins
O campo emergente da engenharia molecular de metaloproteínas visa preparar proteínas artificiais, cujas propriedades podem imitar e talvez até mesmo melhorar várias características encontradas nas metaloenzimas naturais. Este artigo de revisão resume nossos esforços recentes na preparação de metaloproteínas sintéticas, construídas a partir de "co
Journal of the Brazilian Chemical Society. Publicado em: 2006-12
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10. Avaliação do desenvolvimento de girassol por meio de analise de proteinas e metaloproteinas / Evaluation of sunflower development based on protein metalloprotein analysis
This work describes an evaluation of sunflower (Helianthus annuus L.) growth when it is submitted to seven treatments, and their interrelation with proteins and metalloproteins analyses. Metal ion solutions (Cd, Cu, Pb and Zn) were added to the substrate in four treatments. In another two, used as controls, the plants were irrigated only with deionized water
Publicado em: 2006
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11. Finasteride effects on epithelium-stroma interaction in the different rat prostatic lobes / Efeito da finasterida sobre a interação epitelio-estroma nos diferentes lobos da prostata de rato
Prostate cancer cells are generally dependent on androgen stimulation mediated by the androgen receptor (AR) for growth and survival. Therefore, hormonal manipulation, such as castration and/or the use of AR antagonists, results in a regression of the cancer. However, these treatments very rarely lead to the cure of advanced disease and cancer eventually bec
Publicado em: 2006
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12. Contribution to the prognostic assessment of patients with advanced lung adenocarcinoma: evaluation by immunohistochemical methods of thyroid transcription factor-1 and matrix metalloproteinase-9 / "Contribuição à avaliação prognóstica de pacientes com adenocarcinoma pulmonar avançado: estudo imunohistoquímico da expressão do fator 1 de transcrição tireoideano e da metaloproteinase 9"
O valor prognóstico da expressão do Fator 1 de Transcrição Tireoideano (TTF-1) e da metaloproteinase-9 (MMP-9) foi avaliado em 51 pacientes com adenocarcinoma pulmonar avançado. Foram fatores de mau prognóstico: baixa capacidade funcional (P = 0,017), baixa expressão do TTF-1 (P = 0,001) e alta expressão da MMP-9 (P = 0,008). Identificaram-se três g
Publicado em: 2005