Metallopeptidases
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. Comparative transcriptomic analysis of two important life stages of Angiostrongylus cantonensis: fifth-stage larvae and female adults
Abstract The mechanisms involved in the fast growth of Angiostrongylus cantonensis from fifth-stage larvae (L5) to female adults and how L5 breaks through the blood-brain barrier in a permissive host remain unclear. In this work, we compared the transcriptomes of these two life stages to identify the main factors involved in the rapid growth and transition t
Genet. Mol. Biol.. Publicado em: 2017-06
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2. Mucopolissacaridoses : mecanismos patogênicos e abordagens terapêuticas baseadas em terapia gênica e reposição enzimática
In this work we aimed to study the pathogenesis of mucopolysaccharidosis (MPS), especially organs that have been described as difficult-to-reach by current therapies. We also aimed to evaluate new therapies for these diseases. Our studies focused on MPS I and VII mice showed an increase in the activity of proteases, including cathepsins and metallopeptidases
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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3. Efeitos de uma desintegrina RGD recombinante de Rhinocerophis alternatus (Bothrops alternatus) na migração de células normais e tumorais
Cell migration, invasion of the surrounding tissues, blood vessels and proliferation are cellular processes involved in metastases. These events are mediated by integrins, adhesion receptors present on cell surfaces and responsible for the extracellular matrix and cells binding. Disintegrins, snake venoms polypeptides, are known to inhibit integrins action,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2011
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4. Biomarcadores do metabolismo da cartilagem e sua relação com as alterações morfológicas, inflamatórias e funcionais: um estudo sobre a lesão condral secundária em joelhos humanos / Biomarkers of cartilage metabolism and its relationship with morphological, inflammatory and functional changes: a study of secondary chondral injury in human knees
A osteoartrite (OA), doença articular degenerativa, é uma das causas mais freqüentes de dor do sistema músculo-esquelético e de incapacidade para o trabalho no Brasil e no mundo. É uma doença crônica, multifatorial, que leva a uma incapacidade funcional progressiva. Pode surgir em decorrência de lesões em estruturas como ligamento cruzado anterior
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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5. Papel dos receptores B1 e B2 de bradicinina e de captopril nas interações célula hospedeira-Trypanosoma cruzi
The infection of monocytes by Trypanosoma cruzi tripomastigotes is a crucial step for the development of Chagas disease immune response. Infection by T. cruzi has demonstrated to be an active process, involving diverse cellular components and different cell types. Previous studies of the interaction tissue-culture derived trypomastigotes (TCT) between cardio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/08/2010
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6. Efeitos da ovariectomia e treinamento resistido na atividade da metaloproteinase-2 no tendão calcâneo de ratas
Tendons remodeling relies upon extracellular matrix restructuring by the matrix metalloproteinases (MMPs). The aim of this study was to investigate MMP-2 activity in different regions of the calcanear tendon after resistance training in ovariectomized rats. Wistar adult female rats were grouped into: sedentary (Sed-Intact); ovariectomized sedentary (Sed-Ovx)
Publicado em: 2010
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7. Efeitos dos esteróides anabólicos androgênicos sobre a bioquímica, morfologia, biomecânica e expressão gênica de diferentes tendões de ratos submetidos ao exercício de carga
O objetivo desse estudo foi avaliar os efeitos do salto vertical em associação com esteróide anabólico androgênico (EAA) nas propriedades bioquímicas, biomecânicas, morfológicas e a expressão dos principais genes responsáveis pelo remodelamento do tendão calcâneo (TC), tendão flexor superficial (TFS) e tendão flexor profundo (TFP) de ratos. Rat
Publicado em: 2010
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8. The rattlesnake Crotalus durissus terrificus (Viperidae: Crotalinae) as an experimental model to study the involvement of peptidases in the survival of spermatozoids / A cascavel Crotalus durissus terrificus (Viperidae: Crotalinae) como modelo experimental para o estudo do envolvimento de peptidases na sobrevida de espermatozóides
In the rattlesnake Crotalus durissus terrificus occurs the long-term sperm storage (LTSS), in the female tract, during the interval between mating (autumn) and ovulation (spring). Peptides and peptidases are among the main components that influence the spermatic activity in mammals. The present study aimed to characterize the presence of peptidases in C. d.
Publicado em: 2007
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9. Remodelamento do miocárdio no exercício com componente anaeróbico.
The extracellular matrix (ECM) components are continuously synthesized and degraded at distinct rates in a process called remodeling involving the expression of matrix metallopeptidases (MMPs) and their inhibitors (TIMPs) in physiological (growth, exercise) or pathological (high blood pressure, myocardial infarction) conditions. The expression of myosin heav
Publicado em: 2004
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10. Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue.
Proteolytic removal of amino-terminal octapeptides from mitochondrial intermediate proteins is a required step for a subgroup of nuclear-encoded mitochondrial precursors and is specifically catalyzed by mitochondrial intermediate peptidase (MIP). We recently reported the purification of MIP from rat liver and showed that the enzyme is a monomer of 75 kDa. We
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11. Streptococcus parasanguis pepO Encodes an Endopeptidase with Structure and Activity Similar to Those of Enzymes That Modulate Peptide Receptor Signaling in Eukaryotic Cells
Studies in our laboratory have identified two fimbria-associated adhesins, FimA and Fap1, of Streptococcus parasanguis FW213. In this study, we isolated and sequenced DNA fragments linked to fimA to determine if they contained additional factors associated with adherence, virulence, or survival in the host. An open reading frame just upstream and divergently
American Society for Microbiology.
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12. Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".
Neutral endopeptidase 24.11, also known as the common acute lymphoblastic leukemia antigen, is a zinc metallopeptidase involved in the inactivation of biologically active peptides, such as the enkephalins and atrial natriuretic peptide. The highly potent radiolabeled inhibitor 2-((3-[125I]iodo-4-hydroxy)phenylmethyl)-4-N-[3-(hydroxyamino-3-oxo-1- phenylmethy