Metabolism Computational Modeling
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases
ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date comput
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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2. Estudo computacional da etapa fermentativa da produção de cerveja e proposta de uma estratégia de controle para o processo. / Selection of models and proposal of a control strategy for the fermentative stage of the beer production. 2010
Beer is the oldest alcoholic beverage in the world, and its processing has been evolving along the time. Nowadays, beer trading occupies an important position in the economic market since it is the most consumed beverage in Brazil and around the world. Due to this economic significance, the search for more efficient processes that are able to keep the sensor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/03/2010
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3. Metabolic Network Comparison of Bacteria in the Context of Symbiosis / Análise Comparativa de Redes Metabólicas de Bactérias no Contexto da Simbiose
Simbiose é a associação permanente entre dois ou mais organismos de espécies distintas, pelo menos durante uma parte do ciclo de vida. Existe uma grande diversidade de casos de simbiose, os quais são frequentemente classificados de acordo com os benefícios ou deficits no valor adaptativo do hospedeiro, i.e., mutualismo, comensalismo ou parasitismo. Out
Publicado em: 2010
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4. MIA-QSAR MODELING biological activity of inhibitors of phosphodiesterase type-5. / Modelagem Mia-Qsar das atividades biolÃgicas de inibidores de fosfodiesterase tipo-5.
The use of theoretical models to represent and manipulate molecular structures, study chemical reactions and establish relationships between structure and matter properties constitutes the field of application of molecular modeling. In this context, several molecular modeling methods have been developed and should be tested and validated in regard to its app
Publicado em: 2009
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5. SAMPA (Systemn for Comparative Analysis of Metabolic PAthways) / SAMPA (System for Comparative Analysis of Metabolic PAthways) - uma comparação de vias metabólicas
The advent of genome sequencing technology and complete genome analysis has provided new data on prokaryote and eukaryote metabolic pathways. The comparative analysis of metabolic pathways from different organisms can help us understand inter and intra species organizational relationships. Having this in mind, this work focused on building a system that allo
Publicado em: 2008
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6. Modelo de von Bertalanffy generalizado aplicado a curvas de crescimento animal / Generalized von Bertalanffy model applied to growth animal curves
The objective of this work is to study the curve of growth in weight of several animaIs specimens, to establish standards of metabolism for animal class. The parameters of the non-linear generalized form of the von Bertalanffy mo deI applied to weight growth curves were adjusted to identify with ones describe better the growth of the animal on the areas of a
Publicado em: 2008
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7. Uma abordagem de metodos computacionais para simulação de processos biologicos : simulação tridimensional e metabolica do desenvolvimento tumoral / A computational approach for simulation of biological process : tridimensional simulation of tumor metabolism and development
In this work, we created a piece of software and computer models for studying carcinogenesis, in order to answer biological questions related to the treatment of this disease. The computer models were inspired in the theory of Somatic Evolution and Acid Mediated Tumor Invasion, proposed by Gatenby and Gillies, and were implemented in a tool developed by the
Publicado em: 2008
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8. A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae
Recent computational and experimental work suggests that functional modules underlie much of cellular physiology and are a useful unit of cellular organization from the perspective of systems biology. Because interactions among modules can give rise to higher-level properties that are essential to cellular function, a complete knowledge of these interactions
Cold Spring Harbor Laboratory Press.
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9. Analysis of optimality in natural and perturbed metabolic networks
An important goal of whole-cell computational modeling is to integrate detailed biochemical information with biological intuition to produce testable predictions. Based on the premise that prokaryotes such as Escherichia coli have maximized their growth performance along evolution, flux balance analysis (FBA) predicts metabolic flux distributions at steady s
National Academy of Sciences.
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10. Modeling Cardiac Action Potential Shortening Driven by Oxidative Stress-Induced Mitochondrial Oscillations in Guinea Pig Cardiomyocytes
Ischemia-induced shortening of the cardiac action potential and its heterogeneous recovery upon reperfusion are thought to set the stage for reentrant arrhythmias and sudden cardiac death. We have recently reported that the collapse of mitochondrial membrane potential (ΔΨm) through a mechanism triggered by reactive oxygen species (ROS), coupled to the open
The Biophysical Society.