Metabolic Programming
Mostrando 13-24 de 29 artigos, teses e dissertações.
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13. Changes on adult male rats in models of programming induced by hyperleptinaemia during lactation / Alterações neuro-comportamentais em ratos machos adultos em modelos de programação pela hiperleptinemia na lactação
A considerable association exists between variations in nutritional, hormonal and environmental parameters during early life, particularly in the gestational and lactation periods, and the appearance of chronic diseases in adult life, such as obesity, diabetes, cardiovascular diseases, anxiety and depression. In the present study, the cognitive and behaviora
Publicado em: 2009
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14. Reparo Ãsseo com a utilizaÃÃo de cÃlulas tronco em ratos submetidos à desnutriÃÃo neonatal
Malnutrition is a public health problem characterized by low intake of essential nutrients for growth and development of the body. Researches involving malnutrition and its consequences in adult life shows that it is capable to change the metabolic programming that impact throughout life. However, little is known about the sequels involving adult stem cells
Publicado em: 2009
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15. Depleção cerebral de serotonina durante o período neonatal programa a homeostase metabólica energética e a expressão comportamental de ratos adultos. / Brain serotonin depletion during neonatal period programme energetic metabolic homeostasis and behavioral expression of adulthood rats
A depleção cerebral de serotonina (5-HT) durante o período neonatal acarreta uma alteração plástica na citoarquitetura do sistema serotonérgico influenciando diretamente o desenvolvimento ontogênico de diversos sistemas cerebrais. Nesta dissertação objetivou-se elucidar a influência da depleção cerebral de 5-HT durante o período neonatal sobre
Publicado em: 2008
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16. Relationship between the maternal diabetes and the sexual development of the male rat offspring / Relação entre o diabete materno e o desenvolvimento sexual da prole masculina de ratos
Diabetes melllitus is a group of metabolic disorders of multiple etiology, characterized by defects in the secretion and/or action of insulin. The causes of the disease can be genetic and/or environmental. Diabetes is one of the most common metabolic complications during pregnancy and is associated with an increased risk of maternal and neonatal morbidities.
Publicado em: 2007
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17. Mathematical programming techniques for analysis and design of biotechnological systems. / Técnicas de programação matemática para a análise e projeto de sistemas biotecnológicos.
A complexidade de alguns sistemas biotecnológicos impossibilita seu estudo sem o uso de técnicas de programação matemática avançadas. A quantificação de fluxos metabólicos e a síntese e projeto ótimos de plantas multiproduto são problemas com esta característica, abordados na presente tese. A quantificação de fluxos metabólicos empregando bal
Publicado em: 2005
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18. Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1
American Diabetes Association.
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19. Analysis of optimality in natural and perturbed metabolic networks
An important goal of whole-cell computational modeling is to integrate detailed biochemical information with biological intuition to produce testable predictions. Based on the premise that prokaryotes such as Escherichia coli have maximized their growth performance along evolution, flux balance analysis (FBA) predicts metabolic flux distributions at steady s
National Academy of Sciences.
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20. Discrimination of Modes of Action of Antifungal Substances by Use of Metabolic Footprinting
Diploid cells of Saccharomyces cerevisiae were grown under controlled conditions with a Bioscreen instrument, which permitted the essentially continuous registration of their growth via optical density measurements. Some cultures were exposed to concentrations of a number of antifungal substances with different targets or modes of action (sterol biosynthesis
American Society for Microbiology.
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21. A Genome-Scale Metabolic Model of Arabidopsis and Some of Its Properties1[C][W]
We describe the construction and analysis of a genome-scale metabolic model of Arabidopsis (Arabidopsis thaliana) primarily derived from the annotations in the Aracyc database. We used techniques based on linear programming to demonstrate the following: (1) that the model is capable of producing biomass components (amino acids, nucleotides, lipid, starch, an
American Society of Plant Biologists.
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22. Maternal prolactin inhibition during lactation programs for metabolic syndrome in adult progeny
Neonatal malnutrition is associated with metabolic syndrome in adulthood. Maternal hypoprolactinaemia at the end of lactation (a precocious weaning model) caused obesity, leptin resistance and hypothyroidism in adult offspring, suggesting an association of prolactin (PRL) and programming of metabolic dysfunctions. Metabolic syndrome pathogenesis is still unc
Blackwell Science Inc.
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23. Genome-Scale In Silico Models of E. coli Have Multiple Equivalent Phenotypic States: Assessment of Correlated Reaction Subsets That Comprise Network States
The constraint-based analysis of genome-scale metabolic and regulatory networks has been successful in predicting phenotypes and useful for analyzing high-throughput data sets. Within this modeling framework, linear optimization has been used to study genome-scale metabolic models, resulting in the enumeration of single optimal solutions describing the best
Cold Spring Harbor Laboratory Press.
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24. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
Pre- and neonatal overfeeding programmes a permanent obesity disposition and accompanying diabetic and cardiovascular disorders, by unknown mechanisms. We proposed that early overfeeding may alter DNA methylation patterns of hypothalamic promoter regions of genes critically involved in the lifelong regulation of food intake and body weight. We induced neonat
Blackwell Science Inc.