Metabolic Clearance Rate
Mostrando 1-12 de 131 artigos, teses e dissertações.
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1. CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic eliminat
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Inflammation: friend or foe of bovine reproduction?
Abstract Inflammation is not only the first line of defense of the organism but is also required in many reproductive processes such as ovulation, corpus luteum development, luteolysis, uterine clearance after insemination and post partum. Nevertheless, if excessive or persistent, inflammation can switch from a positive mechanism to a deleterious process, im
Anim. Reprod.. Publicado em: 28/11/2019
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3. Validated analytical study of the effect of Lycopene on the pharmacokinetics of Paracetamol and Chlorzoxazone in rats
Lycopene was reported to influence some cytochrome P450 enzymes activity. The present study investigates the effect of lycopene on the pharmacokinetics of paracetamol and chlorzoxazone. Lycopene (20 mg/kg) was intra-peritoneally administered to two groups of rats for eight consecutive days and two other groups were given vehicle. On the eighth day, chlorzoxa
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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4. Flexible ureterorenoscopy is associated with less stone recurrence rates over Shockwave lithotripsy in the management of 10-20 millimeter lower pole renal stone: medium follow-up results
ABSTRACT Purpose To identify the role of shock wave lithotripsy (SWL) and flexible ureterorenoscopy (f-URS) on the stone recurrence, in the management of 10-20 millimeter lower pole stone (LPS) with medium follow-up outcomes. Materials and Methods The patients’ charts which were treated with SWL or f-URS for LPS between January 2011 and September 2013 we
Int. braz j urol.. Publicado em: 2018-04
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5. Plasma kinetics of an LDL-like nanoemulsion and lipid transfer to HDL in subjects with glucose intolerance
OBJECTIVE: Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. Nonetheless, lipid metabolism is scarcely studied in normolipidemic glucose-intolerant patients. The aim of this study was to investigate whether important lipid metabolic parameters, such as the kinetics of LDL free and est
Clinics. Publicado em: 2012
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6. Estudo dos efeitos da alta ingestÃo de cloreto de sÃdio por via oral sobre o metabolismo diÃrio e funÃÃo renal de ratos. / Study of effects on the daily metabolism and the renal function of rats under high oral ingestion of sodium chloride.
Guanylin (GN), uroguanylin (UGN), and the bacterial heat-stable enterotoxin (ST) peptides comprise a new family of cyclic guanosine 3â-5â monophosphate (cGMP)-regulating agonist. Ingestion of a salt meal induces secretion of GN and UGN into the intestinal lumen, where they inhibit Na+ absorption and induces Cl-, HCO3- , and water secretion. Simultaneously,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/01/2009
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7. Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
We have shown that the free cholesterol (FC) and the cholesteryl ester (CE) moieties of a nanoemulsion with lipidic structure resembling low-density lipoproteins show distinct metabolic fate in subjects and that this may be related to the presence of dyslipidemia and atherosclerosis. The question was raised whether induction of hyperlipidemia and atheroscler
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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8. Chylomicron metabolism and lipid reception capacity of high density lipoprotein in metabolic syndrome (MetS) and type 2 diabetes mellitus (DM2) / Metabolismo dos quilomícrons e capacidade da lipoproteína de alta densidade (HDL) de receber lípides na síndrome metabólica e no diabetes mellitus tipo 2
The main metabolic disturbances occurring as a result of type 2 diabetes mellitus (DM2) and Metabolic Syndrome (MetS) are alterations in the metabolism of lipids. It is therefore, important to better understand the aspects by which plasma lipoproteins are metabolized. The evaluation of chylomicron metabolism and lipid transfer of high density lipoprotein (HD
Publicado em: 2008
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9. Critical analysis of chronic peritoneal dialysis prescription in pediatric patients. / Análise crítica da prescrição de diálise peritoneal crônica em pacientes pediátricos
Introdução: Diálise peritoneal (DP) é modalidade de terapia renal substitutiva útil em crianças em estágio final de doença renal. O estado nutricional e o crescimento são considerados como marcadores prognósticos na adequação em diálise pediátrica, que dependem da sua prescrição, do controle da volemia e pressão arterial e do manejo dos dist
Publicado em: 2008
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10. Metabolic assessment in patients with urinary lithiasis
INTRODUCTION: Metabolic investigation in patients with urinary lithiasis is very important for preventing recurrence of disease. The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology. PATIENTS AND METHOD
International braz j urol. Publicado em: 2005-02
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11. Alterations in renal function in HIV/AIDS patients treated with therapeutic regimens including indinavir / "Alterações na função renal em pacientes HIV/AIDS tratados com esquemas terapêuticos incluindo indinavir"
Complicações renais e urológicas incluindo nefrolitíase, cristalúria, cólica renal e lombalgia, são eventos adversos bem conhecidos do indinavir (IDV), um inibidor de protease (IP) largamente utilizado no tratamento de pacientes infectados com o vírus da imunodeficiência humana (HIV). Prévios estudos em ratos demonstraram que o IDV, um potente IP c
Publicado em: 2004
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12. Avaliação das modificações metabolicas durante e apos o emagrecimento em pacientes portadores de obesidade classe III, submetidos a cirurgia de gastroplastia vertical com bandagem e derivação gastro-jejunal
Obesity has a high prevalence and an increasing incidence, being considered epidemic. It is characterized by hyperinsulinemia and insulin resistance, important early metabolic changes in the obese patient. The first has been reported as an independent cardiovascular risk factor. The mechanisms underlying hyperinsulinemia are not clear and it has been associa
Publicado em: 2002