Metabolic Clearance Rate
Mostrando 13-24 de 131 artigos, teses e dissertações.
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13. Pressão arterial e manipulação tubular renal de sodio em um modelo de septicemia em ratos
Acute renal failure is a frequent complication in septic patients associated with a high mortality rate. An important characteristic is a decrease in glomerular filtration rate, which is even present in situations where renal blood flow has been maintained. Prevailing hypothesis on the pathogenesis of renal failure suggest an inappropriate and uncontrolled r
Publicado em: 2001
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14. Metabolic clearance rate of radioiodinated human calcitonin in man
The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both from
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15. The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols
Dihydrotestosterone metabolism was studied with a constant infusion technique in three men, three women, five hirsute women, and four estrogen-treated hirsute women. The mean dihydrotestosterone metabolic clearance rate was higher in men (336 liters/24 hr per m2 [range, 239-448]) than in women (153 liters/24 hr per m2 [range, 108-184]). The metabolic clearan
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16. A decreased metabolic clearance rate of aldosterone in benign essential hypertension
Aldosterone secretion rate, metabolic clearance rate, and/or plasma concentration were determined in 16 patients with benign, uncomplicated essential hypertension and compared with those of control subjects. The mean metabolic clearance rate of aldosterone in 10 patients was significantly (P < 0.001) lower (mean 867 liters of plasma/day per m2 ±270 SD) than
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17. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.
To determine the plasma epinephrine thresholds for its metabolic and hemodynamic actions and plasma epinephrine metabolic clearance rates, 60-min intravenous epinephrine infusions at nominal rates of 0.1, 0.5, 1.0, 2.5, and 5.0 microgram/min were performed in each of six normal human subjects. These 30 infusions resulted in steady-state plasma epinephrine co
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18. Metabolic clearance rate of radioiodinated human growth hormone in man
The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of study (4
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19. 3α-Androstanediol Kinetics in Man
Kinetics of 5α-androstane-3α, 17β-diol (3α-diol) were studied in man. Clearance rates were determined by both the constant infusion and single injection techniques. Production rates were calculated as the product of clearance rate data and plasma values in the a.m. obtained by a radioimmunoassay specific for 3α-diol. Mean metabolic clearance rates were
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20. Metabolism of Proinsulin, Insulin, and C-Peptide in the Rat
The renal extraction and excretion of bovine proinsulin, insulin, and C-peptide and the contribution of the kidney to their total metabolic clearance rate (MCR) were studied in the rat. Metabolic clearance rates were measured by the constant infusion technique and plasma and urine concentrations of each polypeptide were determined by radioimmunoassay.
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21. Growth Hormone: Metabolic Clearance Rates, Integrated Concentrations, and Production Rates in Normal Adults and the Effect of Prednisone
A constant withdrawal pump was used to determine the integrated concentration of growth hormone (ICGH) which was used in conjunction with the metabolic clearance rate (MCR) of growth hormone (GH) to calculate the GH production rates (GHPR) in normal adults, acromegalics, and normal controls receiving prednisone.
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22. Distribution, blood transport, and degradation of antidiuretic hormone in man.
The distribution, blood transport, and metabolic clearance of physiological concentrations of antidiuretic hormone were studied in 10 hydrated normal subjects with radioiodinated arginine vasopressin (125I-AVP). At 37 degrees C no binding of 125I-AVP to plasma proteins could be demonstrated, but some metabolites were associated with plasma proteins. 125I-AVP
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23. The metabolic clearance rate of progesterone in males and ovariectomized females.
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24. Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3′-L-triiodothyronine and L-thyroxine
Administration of phenobarbital, which acts exclusively on cellular sites, results in an augmentation of the liver/plasma concentration ratio of L-thyroxine (T4) in rats but no change in the liver/plasma concentration ratio of L-triiodothyronine (T3). Whereas phenobarbital stimulates the fecal clearance rate both of T3 and T4, it increases the deiodinative c