Meningococcal Infection
Mostrando 13-24 de 82 artigos, teses e dissertações.
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13. Recombinant Neisseria meningitidis Transferrin Binding Protein A Protects against Experimental Meningococcal Infection
To better characterize the vaccine potential of Neisseria meningitidis transferrin binding proteins (Tbps), we have overexpressed TbpA and TbpB from Neisseria meningitidis isolate K454 in Escherichia coli. The ability to bind human transferrin was retained by both recombinant proteins, enabling purification by affinity chromotography. The recombinant Tbps we
American Society for Microbiology.
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14. Transcriptome Analysis of Neisseria meningitidis during Infection
Neisseria meningitidis is the cause of septicemia and meningococcal meningitis. During the course of infection, N. meningitidis encounters multiple environments within its host, which makes rapid adaptation to environmental changes a crucial factor for neisserial pathogenicity. Employing oligonucleotide-based DNA microarrays, we analyzed the transcriptome of
American Society for Microbiology.
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15. Experimental meningococcal infection in mice: a model for mucosal invasion.
A more complete understanding of meningococcal disease has been hampered by the lack of an appropriate animal model. Previous models have utilized injections of meningococci, which precludes the study of nasopharyngeal colonization and invasion. We have developed a model for meningococcal disease in which litters of 5-day-old mice are challenged intranasally
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16. Ultrasound-Enhanced Latex Immunoagglutination and PCR as Complementary Methods for Non-Culture-Based Confirmation of Meningococcal Disease
Preadmission administration of antibiotics to patients with suspected meningococcal infection has decreased the likelihood of obtaining an isolate and has stimulated development of rapid and reliable non-culture-based diagnostic methods. The sensitivity of the conventional test card latex agglutination test (TCLAT) for detection of capsular polysaccharide ha
American Society for Microbiology.
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17. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
As the central component of the human endotoxin sensor, Toll-like receptor 4 (TLR4) functions in the early detection and response to Gram-negative infection. We therefore examined a large collection of patients with meningococcal sepsis, comparing the frequency of rare TLR4 coding changes to those in an ethnically matched control population. TLR2 sequences w
The National Academy of Sciences.
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18. Isolated septic arthritis: meningococcal infection
The Royal Society of Medicine.
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19. Meningococcal infection: serological studies.
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20. Meningococcal infection: serotypes and suplhonamide sensitivity.
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21. Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection
Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.
American Society for Microbiology.
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22. INVESTIGATIONS OF MENINGOCOCCAL INFECTION. I. BACTERIOLOGICAL ASPECTS 1
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23. INVESTIGATIONS OF MENINGOCOCCAL INFECTION. II. IMMUNOLOGICAL ASPECTS 1
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24. Diversity in pathogenicity can cause outbreaks of meningococcal disease
Neisseria meningitidis, the meningococcus, is a major cause of bacterial meningitis and septicemia worldwide. Infection in most cases leads to asymptomatic carriage and only rarely to disease. Meningococcal disease often occurs in outbreaks, which are both sporadic and highly unpredictable. The occurrence of disease outbreaks in a host population in which th
National Academy of Sciences.