Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection

AUTOR(ES)

Winzer, Klaus

FONTE

American Society for Microbiology

RESUMO

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

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