Mechanical Allodynia
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats
Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. NF-kB mediated CX3CL1 activation in the dorsal root ganglion contributes to the maintenance of neuropathic pain induced in adult male Sprague Dawley rats
Abstract Purpose: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. Methods: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested at relevant time points during an observation period of 28
Acta Cir. Bras.. Publicado em: 2018-07
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3. Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
Abstract Purpose: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Methods: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincris
Acta Cir. Bras.. Publicado em: 2018-06
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4. Quantitative methods for somatosensory evaluation in atypical odontalgia
A systematic review was conducted to identify reliable somatosensory evaluation methods for atypical odontalgia (AO) patients. The computerized search included the main databases (MEDLINE, EMBASE, and Cochrane Library). The studies included used the following quantitative sensory testing (QST) methods: mechanical detection threshold (MDT), mechanical pain th
Braz. oral res.. Publicado em: 23/01/2015
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5. Expression of MMP-2 and MMP-9 in the rat trigeminal ganglion during the development of temporomandibular joint inflammation
Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs). This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs). TMJ inflammation is considered to be a cause of pain in patients w
Braz J Med Biol Res. Publicado em: 18/11/2013
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6. Mobilização neural em rato Wistar reverte comportamento e mudanças celulares que caracterizam a dor neuropática. / Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats Wistar.
The Neural Mobilization technique is a noninvasive method that has proved clinically effective in reducing pain sensitivity and consequently in improving quality of life after neuropathic pain. The present study examined the effects of Neural Mobilization (MOB) on pain sensitivity induced by chronic constriction injury (CCI) in rats. The CCI was performed on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012
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7. Estratégia terapêutica após contusão da medula espinhal: recuperação funcional e estabilidade cortical sensório-motora / Therapeutic strategy after spinal cord contusion: functional recovery and sensorimotor cortical stability
Spinal cord injury (SCI) results in a devastating condition, which leads to motor and sensory deficits that impair the injured person functional performance. Spinal cord injury experimental models are used in sensory-motor functioning and reorganization or plasticity promoted by trainings investigation. Thus, these studies can corroborate with current and fu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/08/2011
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8. Characterization of gelatinases in the trigeminal ganglion during development of chronic temporomandibular inflammation in rats / Caracterização das gelatinases no gânglio trigeminal durante o desenvolvimento de inflamação crônica temporomandibular em ratos
A dor é um importante sintoma que sinaliza danos teciduais ou agentes potencialmente prejudiciais ao organismo, evocando respostas sensoriais e motoras de proteção. A dor orofacial apresenta alta prevalência na sociedade atual, sendo esta condição associada a tecidos duros e moles da cabeça, face, pescoço e a estruturas intraorais. Considerando as do
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/05/2011
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9. Avaliação do papel da 5-hidroxitriptamina (5-HT) no processamento periférico da resposta nociceptiva
5-Hydroxytryptamine (5-HT, serotonin) is a cell-derived vasoactive amine, released primarily by platelets (in humans), mast cells (in rodents) and endothelial cells. It is a regulator of smooth muscle in the cardiovascular and gastrointestinal systems, an enhancer of platelet aggregation, and a neurotransmitter in the central nervous system. Although 5-HT is
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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10. Participation of neuronal nitric oxide synthase in experimental neuropathic pain induced by sciatic nerve transection
Nerve injury leads to a neuropathic pain state that results from central sensitization. This phenomenom is mediated by NMDA receptors and may involve the production of nitric oxide (NO). In this study, we investigated the expression of the neuronal isoform of NO synthase (nNOS) in the spinal cord of 3-month-old male, Wistar rats after sciatic nerve transecti
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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11. Mobilização neural como recurso terapêutico na recuperação funcional e morfológica do nervo ciático de ratos após lesão traumática
The present study examined the effects of Neural Mobilization (NM) in the functional sensory-motor recovery after sciatic nerve crush injury in rats. The nerve crush was performed on adult male rats, submitted to 15 sessions of passive neural mobilization treatment through a modified straight leg raise (SLR) test, with groups starting at 3 different times:1,
Publicado em: 2009
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12. Activation of proteinase-activated receptor 2 activation, a signal to joint innate immune responses. / Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.
We hypothesised that the early pro-inflammatory effects of proteinase-activated receptor 2 (PAR2) activation in the temporomandibular joint (TMJ) are mediated by neurogenic mechanisms. Immunofluorescence analysis revealed a high degree of neurons expressing PAR2 in retrogradely labelled trigeminal ganglion neurons. Furthermore, PAR2 immunoreactivity was obse
Publicado em: 2009