Activation of proteinase-activated receptor 2 activation, a signal to joint innate immune responses. / Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

We hypothesised that the early pro-inflammatory effects of proteinase-activated receptor 2 (PAR2) activation in the temporomandibular joint (TMJ) are mediated by neurogenic mechanisms. Immunofluorescence analysis revealed a high degree of neurons expressing PAR2 in retrogradely labelled trigeminal ganglion neurons. Furthermore, PAR2 immunoreactivity was observed in the lining layer of the TMJ, co-localizing with the neuronal marker PGP9.5 and substance P-containing peripheral sensory nerve fibres. The intra-articular injection of PAR2 agonists into the TMJ triggered a dose-dependent increase in plasma extravasation, neutrophil influx and induction of mechanical allodynia. The pharmacological blockade of NK1 receptors abolished PAR2-induced plasma extravasation and inhibited neutrophil influx and mechanical allodynia. We conclude that PAR2 activation is pro-inflammatory in the TMJ, through a neurogenic mechanism involving NK1 receptors. This suggests that PAR2 is an important component of innate neuro-immune response in the TMJ.

ASSUNTO(S)

carrageenan pain substância p carragenina artrite substance p arthritis inflammation inflamação articulação temporomandibular temporomandibular joint. dor

ACESSO AO ARTIGO

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