Matrix Metalloproteinases Inhibitors
Mostrando 1-12 de 74 artigos, teses e dissertações.
-
1. Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin’s lymphoma patients
Abstract Objective: The aim of our study was to evaluate the expression of MMP-2 and MMP-9 as a prognostic factor in patients diagnosed with Hodgkin Lymphoma (HL). Methods: In the present study, 45 paraffin biopsies from patients up to 19 years old diagnosed with HL were used in two referral hospitals in the state of Pernambuco, Brazil. Risk groups were cl
Jornal de Pediatria. Publicado em: 2023
-
2. Updating the role of matrix metalloproteinases in mineralized tissue and related diseases
Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ran
J. Appl. Oral Sci.. Publicado em: 09/09/2019
-
3. Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases
Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Huma
Clinics. Publicado em: 06/09/2018
-
4. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
-
5. Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause
Objectives To analyze the expression of genes involved in extracellular matrix (ECM) biogenesis and remodeling in vaginal tissue of women with clinically normal pelvic floor support (defined as controls) according to the phase of menstrual cycle and postmenopausal women with and without pelvic organ prolapse (POP). Materials and Methods This study examine
Int. braz j urol.. Publicado em: 2013-04
-
6. Graduação histológica e expressão de metaloproteinases (MMP-9 e MMP-2) e seus inibidores (TIMP-1 e TIMP-2) na glândula mamária canina neoplásica / Histological grade and expression of matrix metalloproteinases (MMP-9 e TIMP-2) and their inhibitors (TIMP-1 and TIMP-2) in neoplastic canine mammary gland
Nas fêmeas caninas, as glândulas mamárias são os locais mais comuns para a ocorrência de neoplasias. Para avaliar o comportamento biológico dessas lesões empregam-se rotineiramente métodos histológicos descritivos que, associados à graduação histológica, auxiliam na predição prognóstica dessas enfermidades. Ainda, o desequilíbrio entre a qua
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2012
-
7. Mecanismos envolvidos na resposta imune e inflamatória frente à implantação de membrana de cortical óssea bovina no tecido subcutâneo de camundongos: caracterização histomorfométrica, imunoenzimática e molecular / Mechanisms involved in immune and inflammatory response to implantation of bovine bone cortical membrane in subcutaneous tissue of mice: characterization histomorphometric, imunoenzimatic and molecular
Advances related to the biomaterials science and tissue engineering seek to clarify the mechanisms involved in the biological response associated with the use of those devices and their interaction with the immune system. This study evaluated the inflammatory and immune response developed in mice after implantation bovine bone cortical membrane in subcutaneo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/06/2012
-
8. Papel de TGFβ-1 na regulação da expressão de MMPs seus inibidores (TIMPs e Reck) em modelo de carcinoma mamário humano: análise funcional de RECK e sua correlação com dados clínico-patológicos / Role of TGFβ-1 as a common regulator of MMPs and their inhibitors (TIMPs e RECK) in human breast cancer cell model: functional analysis of RECK and its correlation with clinical-pathological
The metastatic disease is the main mortality cause of breast cancer patients. The metastatic process involves a complex cascade of events, including the organized breakdown of the extracellular matrix (ECM) compounds. The degradation of ECM is tightly regulated by the balance between the activities of matrix metalloproteinases (MMPs) and their inhibitors, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/10/2011
-
9. Estudo da expressão imuno-histoquímica das MMPs -2, -7, -9 e -26 e TIMPs -1 e -2 em adenomas pleomórficos e carcinomas adenóides císticos de glândulas salivares menores
O balanço entre a expressão das metaloproteinases da matriz (MMPs) e seus inibidores teciduais (TIMPs) tem sido relacionado a vários processos fisiológicos e patológicos, incluindo a morfogênese de glândulas salivares e os processos de invasão e metástase tumoral. O adenoma pleomórfico (AP) e o carcinoma adenóide cístico (CAC) representam, respec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2011
-
10. Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent manner
Angiotensin II (ANG II), the main effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and also vascular remodeling through induction of inflammatory genes. Matrix metalloproteinases (MMPs) are considered to be important inflammatory factors. Elucidation of ANG II signaling pathw
Braz J Med Biol Res. Publicado em: 2011-03
-
11. Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer
Publicado em: 2010
-
12. Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer
Our objective was to determine the presence of vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and MMP-9 and specific tissue inhibitors of matrix metalloproteinase (TIMP-1 and TIMP-2) in tumor samples obtained from patients with primary breast cancer. We attempted to correlate these findings with the status of the sentinel lymph
Brazilian Journal of Medical and Biological Research. Publicado em: 04/09/2009