Liver Regeneration
Mostrando 13-24 de 199 artigos, teses e dissertações.
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13. Effects of ischemic preconditioning in a pig model of large-for-size liver transplantation
OBJECTIVE: In most cases of pediatric liver transplantation, the clinical scenario of large-for-size transplants can lead to hepatic dysfunction and a decreased blood supply to the liver graft. The objective of the present experimental investigation was to evaluate the effects of ischemic preconditioning on this clinical entity. METHODS: Eighteen pigs were
Clinics. Publicado em: 2015-02
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14. Effect of cyclosporine on liver regeneration in partial hepatectomized rats
PURPOSE:To evaluate the influence of the cyclosporine in liver regeneration in rats submitted to an experimental model of 70% hepatectomy.METHODS: Forty male rats were randomly divided in four subgroups (C.24h, C.7d, E.24h, E.7d), according to the drug used and the day of sacrifice (24 hours and 7 days). Cyclosporine (10mg/Kg/day) was given to the study subg
Acta Cir. Bras.. Publicado em: 2015-01
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15. Evaluation of liver regeneration with use of diet supplemented with l-arginine
PURPOSE:To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings.METHODS:Thirty-six rats were divided into two groups, control and L- arginine. The first received standard chow and
Acta Cir. Bras.. Publicado em: 2014-09
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16. DNA methylation dynamics in the rat EGF gene promoter after partial hepatectomy
Epidermal growth factor (EGF), a multifunctional growth factor, is a regulator in a wide variety of physiological processes. EGF plays an important role in the regulation of liver regeneration. This study was aimed at investigating the methylation level of EGF gene throughout liver regeneration. DNA of liver tissue from control rats and partial hepatectomy (
Genet. Mol. Biol.. Publicado em: 2014-06
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17. Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydrogenases expression in hepatectomized rats
PURPOSE: To evaluate the relative gene expression (RGE) of cytosolic (MDH1) and mitochondrial (MDH2) malate dehydrogenases enzymes in partially hepatectomized rats after glutamine (GLN) or ornithine alpha-ketoglutarate (OKG) suplementation. METHODS: One-hundred and eight male Wistar rats were randomly distributed into six groups (n=18): CCaL, GLNL and OKGL
Acta Cir. Bras.. Publicado em: 2014-06
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18. The ileum positively regulates hepatic regeneration in rats
PURPOSE: To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum.METHODS:Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 - sham. Anesthesia with ketamine and xylazine i.p., aseptic technique, analgesia with meperidine (10mg/kg s.
Acta Cir. Bras.. Publicado em: 2014-02
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19. In vitro proliferation and differentiation of hepatic oval cells and their potential capacity for intrahepatic transplantation
Hepatic oval cells (HOCs) are recognized as facultative liver progenitor cells that play a role in liver regeneration after acute liver injury. Here, we investigated the in vitro proliferation and differentiation characteristics of HOCs in order to explore their potential capacity for intrahepatic transplantation. Clusters or scattered HOCs were detected in
Braz J Med Biol Res. Publicado em: 30/07/2013
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20. Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats
PURPOSE: To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH). METHODS: Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats r
Acta Cir. Bras.. Publicado em: 2013-06
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21. Efeito da hepatectomia parcial associada à administração de fatores nutricionais hepatotróficos sobre a morfologia, função e expressão de genes pró-fibróticos na cirrose hepática em ratos Wistar induzida por tiocetamida / Effects of partial hepatectomy associated with administration of nutritional hepatotrophic factors in morphology, function and expression of pro-fibrotic genes in thioacetamide-induced liver cirrhosis in Wistar rats
The current study evaluated the role of parenteral solution of nutritional hepatotrophic factors in animals with cirrhosis undergoing partial hepatectomy. This procedure is fearful in these animals due to the possibility of acute liver failure, since removal of a liver fragment further reduces the functional capacity of an already compromised organ. Moreover
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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22. The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition
Maternal malnutrition during the lactation period in early development may have long-term programming effects on adult offspring. We evaluated the combined effects of parasitological behaviour and histopathological features and malnutrition during lactation. Lactating mice and their pups were divided into a control group (fed a normal diet of 23% protein), a
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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23. Alterations in DNA repair gene expression and their possible regulation in rat-liver regeneration
Rapidly proliferating tissue may require enhanced DNA repair capacity in order to avoid fixation of promutagenic DNA lesions to mutations. Partial hepatectomy (PH) triggers cell proliferation during liver regeneration (LR). However, little is known on how DNA repair genes change and how they are regulated at the transcriptional level during LR. In the presen
Genetics and Molecular Biology. Publicado em: 08/04/2011
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24. Avaliação do emprego da pentoxifilina na regeneração hepática em ratos submetidos à hepatectomia parcial / Effect of pentoxifylline in liver regeneration in rats submitted to partial hepatectomy
Liver surgery has grown extraordinarily from the first planned ressection performed by Langenbuch in 1888, and the first successful orthotopic liver transplantation by Starzl in 1963 to the extended liver resections and living donors liver transplantations currently performed in many centers. It occurred, among others factors, because of the recognition of t
Publicado em: 2010