Lin28b
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of urolithin A in a stable full-length HBV gene integrated cell li
Braz J Med Biol Res. Publicado em: 07/05/2018
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2. Análise dos genes LIN28B, KISS1 e KISS1R em crianças com puberdade precoce central idiopática / LIN28B, KISS1 and KISS1R genes analysis in children with idiophatic central precocious puberty
A puberdade é um processo biológico complexo do desenvolvimento sexual que tem início no final da infância e se caracteriza pela maturação do eixo hipotálamo-hipófise-gonadal, pelo desenvolvimento dos caracteres sexuais secundários, aceleração do crescimento e finalmente pela capacidade reprodutiva. Nos últimos anos, o peptídeo kisspeptina e seu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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3. Estabilidade de geleia de jambo-vermelho (Eugenia malaccensis , Lin.)em copo de vidro
Foram estudadas algumas características físicas e químicas do jambo (Eugenia mataccemis, L.) com o objetivo de se desenvolver tecnologicamente a formulação para a geléia do fruto com e sem casca, fazendo-se o controle químico, físico, microbiológico e análise sensorial dos produtos acabados e estocados a 25 e 35°C, com e sem luz, por um período d
Publicado em: 1994
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4. Isolado proteico de girassol obtenção e propriedades / Isolated protein sunflower production and properties
The physical and chemical characteristics of eight varieties of sunflower seeds of commercia1 importance in Brazil were studied.The IAC-Anhandy, a new cultivar devéloped at the Instituto Agronômico in Campinas, SP, presented the highest levels of oil and ] ernel. The protein content of the several varieties of sunflower seeds ranged from 15.38% to 25.28%.
Publicado em: 1984
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5. Cloning and sequencing of a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase gene involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis.
In Pseudomonas paucimobilis UT26, gamma-hexachlorocyclohexane (gamma-HCH) is converted to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL), which is then metabolized to 2,5-dichlorohydroquinone. Here, we isolated from the genomic library of UT26 two genes which expressed 2,5-DDOL dehydrogenase activity when they were transformed into P. putida and Escheri
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6. Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β
The NF-κB/Rel family of eukaryotic transcription factors plays an essential role in the regulation of inflammatory, antiapoptotic, and immune responses. NF-κB is activated by many stimuli including costimulation of T cells with ligands specific for the T-cell receptor (TCR)-CD3 complex and CD28 receptors. However, the signaling intermediates that transduce
American Society for Microbiology.
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7. Protein synthesis in Brucella abortus induced during macrophage infection.
Brucella abortus is a facultative, intracellular, pathogenic bacterium that replicates within macrophages and resists macrophage microbicidal mechanisms. To study gene expression and to elucidate the defense mechanisms used by B. abortus to resist destruction within macrophages, protein synthesis by B. abortus was examined by pulse-labeling techniques during
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8. Mutations that affect the translation efficiency of Tn9-derived cat gene in Bacillus subtilis.
We have isolated two spontaneous mutations that increase the expression of the Tn9-derived cat gene in Bacillus subtilis. These mutations, which appear to affect initiation of translation of chloramphenicol acetyltransferase (CAT; acetyl-CoA:chloramphenicol 3-O-acetyltransferase, EC 2.3.1.28) consist of a tandem duplication and triplication of a 55-base-pair
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9. Prevalence and Mechanisms of Macrolide Resistance in Invasive and Noninvasive Group B Streptococcus Isolates from Ontario, Canada
Macrolide resistance has been demonstrated in group B streptococcus (GBS), but there is limited information regarding mechanisms of resistance and their prevalence. We determined these in GBS obtained from neonatal blood cultures and vaginal swabs from pregnant women. Of 178 isolates from cases of neonatal GBS sepsis collected from 1995 to 1998, 8 and 4.5% w
American Society for Microbiology.
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10. Characterization of a Bacteroides Mobilizable Transposon, NBU2, Which Carries a Functional Lincomycin Resistance Gene
The mobilizable Bacteroides element NBU2 (11 kbp) was found originally in two Bacteroides clinical isolates, Bacteroides fragilis ERL and B. thetaiotaomicron DOT. At first, NBU2 appeared to be very similar to another mobilizable Bacteroides element, NBU1, in a 2.5-kbp internal region, but further examination of the full DNA sequence of NBU2 now reveals that
American Society for Microbiology.
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11. Isolation and Characterization of Pediocin AcH Chimeric Protein Mutants with Altered Bactericidal Activity
A collection of pediocin AcH amino acid substitution mutants was generated by PCR random mutagenesis of DNA encoding the bacteriocin. Mutants were isolated by cloning mutagenized DNA into an Escherichia coli malE plasmid that directs the secretion of maltose binding protein-pediocin AcH chimeric proteins and by screening transformant colonies for bactericida
American Society for Microbiology.
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12. Genetic Diversity of the Outer Surface Protein C Gene of Southern Borrelia Isolates and Its Possible Epidemiological, Clinical, and Pathogenetic Implications
The ospC genes of 20 southern Borrelia strains were sequenced. The strains consisted of B. burgdorferi sensu stricto, B. andersonii, B. bissettii, one undescribed genospecies, MI-8, and one probably new Borrelia species, TXW-1. A high degree of similarity exists between B. burgdorferi sensu stricto and B. bissettii and between B. bissettii and B. andersonii.
American Society for Microbiology.