Ligand Exchange
Mostrando 1-12 de 169 artigos, teses e dissertações.
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1. Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells
Abstract Background Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity has been previously suggested. However, the m
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/05/2018
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2. Cellulose Oxidation and the Use of Carboxyl Cellulose Metal Complexes in Heterogeneous Catalytic Systems to Promote Suzuki-Miyaura Coupling and C-O Bond Formation Reaction
This work shows the modification of microcrystalline cellulose by the selective oxidation of primary hydroxyl groups to carboxylate groups by a 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated system and its application as a heterogeneous ligand by ionic exchange with catalytic metals ions such as palladium, nickel and copper. Afterwards is desc
J. Braz. Chem. Soc.. Publicado em: 2017-11
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3. Prevalence of the rs1801282 single nucleotide polymorphism of the PPARG gene in patients with metabolic syndrome
Objective This study aimed to get the genotypic and allelic frequencies of rs1801282 in 179 volunteer donors and 154 patients with Metabolic syndrome (MetS) in Brasilia, Brazil and also examine the association with anthropometric, biochemical and hemodynamic variables in the latter group. MetS comprises a group of diseases resulting from insulin resistance,
Arch. Endocrinol. Metab.. Publicado em: 2015-08
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4. EFEITO DA ESTRUTURA MOLECULAR DE LIGANTES DE SUPERFÍCIE EM PONTOS QUÂNTICOS DE CdTe DISPERSOS EM ÁGUA
Water-soluble CdTe quantum dots are synthesized to investigate how short-chain surface ligands bearing -SH, -COOH, and -NH2 groups interact with CdTe during nucleation/growth processes. Their optical properties and colloidal stability after the ligand exchange are also investigated. We then characterize the resulting CdTe by fluorescence, UV–Vis absorption
Quím. Nova. Publicado em: 2015-01
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5. Influence of extractant and soil type on molecular characteristics of humic substances from two brazilian soils
Num estudo anterior, observou-se que substâncias húmicas (HS) extraídas com solução de NaOH e com solução de Na4P2O7 apresentaram diferentes pesos moleculares, e que o rendimento de HS extraídas por cada método variou entre um Oxisol e um Mollisol do Sul do Brazil. No presente trabalho, o estudo da matéria orgânica nestes solos foi continuado, atr
Publicado em: 2010
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6. Estudo da interação do vanádio (V) com ácidos [beta]-alaninoidroxâmico, glicinoidroxâmico e [alfa]-alaninoidroxâmico em solução aquosa $h [manuscrito] : $b uma abordagem a partir da DFT
The discovery of the potential insulin-mimetic properties of vanadium compounds has stimulated research about the clinical use of these compounds. The effects of different organic groups in the geometry, electronic structure and chemical properties of the vanadium coordination compounds are of fundamental importance to understand the chemical reactivity and
Publicado em: 2009
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7. Isolamento, caracterização termodinâmica e estudos bioquímicos da lectina de sementes dormentes e de cotilédones de sementes germinadas da leguminosa Macrotyloma axillare
The Macrotyloma axillare seed lectin (LMA) is an N-acetyl-galactosamine (GalNac) specific lectin very important in biothecnology because the specific hemmaglutination by A1 human erythrocytes. In this work, the LMA from dormant and germinated was purified by precipitation techniques and ion exchange chromatography as a new purification technique. Such method
Publicado em: 2008
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8. Elucidation of chiral Recognition mechanism of alpha-amino acids using ligand exchange high performance liquid chromatography
A técnica de HPLC por troca de ligante foi utilizada para a separação de racematos de amino ácidos com cadeia lateral alifática. Para tanto, o seletor quiral escolhido foi o complexo de Cu(II) combinado com a L-fenilalananina. Os resultados mostram que o primeiro enanciômero a eluir foi a forma D, seguido da forma L. Segundo o conceito de interação d
Journal of the Brazilian Chemical Society. Publicado em: 2007
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9. Biochemical and molecular characterization of the Leishmania spp. telomerase reverse transcriptase component / Caracterização bioquimica e molecular do componente transcriptase reversa da telomerase de Leishmania spp
Telomeres are protein-DNA complexes that protect linear chromosomes from degradation, providing genomic stability. The telomeric sequences are G-rich and contain a 3 single-stranded region that protrudes toward the chromosome end. In Leishmania, the telomeric DNA is composed by the conserved 5 -TTAGGG-3 repeated sequence and it is replicated by telomerase. T
Publicado em: 2007
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10. Myoglobins: the link between discoloration and lipid oxidation in muscle and meat
Aerobic metabolism changes rapidly to glycolysis post-mortem resulting in a pH-decrease during the transformation of muscle in to meat affecting ligand binding and redox potential of the heme iron in myoglobin, the meat pigment. The "inorganic chemistry" of meat involves (i) redox-cycling between iron(II), iron(III), and iron(IV)/protein radicals; (ii) ligan
Química Nova. Publicado em: 2006-12
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11. Chiral Ligand Exchange Chromatography: Separation of Enantiomeric Mixtures of Underivatized α-Amino Acids under UV Detection
Misturas de enantiômeros de alanina, serina, threonina, valina, metionina, leucina e norleucina foram resolvidas cromatograficamente (e reprodutivelmente), através de cromatografia líquida de alta eficiência (CLAE) com fase reversa, por troca de ligantes, utilizando-se L-prolina, L-hidroxiprolina ou N,N-dimetil-L-fenilalanina (2 mmol L-1) e Cu(CH3COO)2 (
Journal of the Brazilian Chemical Society. Publicado em: 2002-09
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12. Adição de aliltricloroestananas a aldeidos dipeptidicos
The strategies developed for designing inhibitors active against HIV-1 protease involve the incorporation of a dipeptide isostere that resembles the tetrahedral intermediate for peptide bond hydrolysis. The hydroxy amino acid framework B, where the peptidic linkage of the sequence in A is replaced by a CH(OH)CH2 group, resulted as the core unit of potent inh
Publicado em: 2001