Leukemogenesis
Mostrando 1-12 de 224 artigos, teses e dissertações.
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1. Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature
Abstract Introduction Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases o
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice
Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T cell receptor rearrangement, frequently associated wit
Braz J Med Biol Res. Publicado em: 27/05/2019
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3. Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis criteria for chronic lymphocytic leukemia (CLL). MBL may precede the development of CLL, but the molecular mechanisms responsible for disease progression and evolution are not completely known. Telomeres
Braz J Med Biol Res. Publicado em: 13/04/2017
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4. Caracterização molecular e funcional de ANKHD1 na hematopoese normal e neoplasica / Molecular and functional characterization of ANKHD1 in normal and neoplastic hematopoiesis
The identification and the structural and functional characterization of genes differentially expressed between tumors and normal tissues are fundamental steps towards the understanding of the neoplastic process and the development of new anti-cancer strategies. The Ankyrin Repeat Single KH Domain containing 1 (ANKHD1) was first described in humans in a pros
Publicado em: 2009
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5. Expressão imunoistoquímica de p53 e bcl-2 em casos de leucose enzoótica bovina / Immunohistochemical expression of p53 and bcl-2 in enzootic bovine leukosis cases
A Leucose Enzoótica Bovina é uma doença crônica de ocorrência mundial que acomete bovinos. Seu agente etiológico é um retrovírus do mesmo grupo dos que causam a leucemia linfocítica crônica e a AIDS, importantes doenças que acometem humanos. Os retrovírus são vírus que se integram ao DNA do hospedeiro e desta forma são potencialmente mutagêni
Publicado em: 2008
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6. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia
MicroRNAs (miRNAs) are a class of small endogenous RNAs that play important regulatory roles by targeting mRNAs for cleavage or translational repression. miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis, suggesting their association with cancer. We determined the miRNA expression profile of chronic a
Brazilian Journal of Medical and Biological Research. Publicado em: 22/10/2007
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7. Combating oncogene activation associated with retrovirus-mediated gene therapy of X-linked severe combined immunodeficiency
A successful gene therapy clinical trial that also encountered serious adverse effects has sparked extensive study and debate about the future directions for retrovirus-mediated interventions. Treatment of X-linked severe combined immunodeficiency with an oncoretrovirus harboring a normal copy of the gc gene was applied in two clinical trials, essentially cu
Brazilian Journal of Medical and Biological Research. Publicado em: 14/03/2007
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8. Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes. Expansion and contraction of microsatellite sequences due to a deficient mismatch repair system are a marker of the mutator phenotype. Controversial results r
Genetics and Molecular Biology. Publicado em: 2004
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9. Macrophages are the first thymic cells to express polytropic retrovirus in AKR mouse leukemogenesis.
AKR mice spontaneously develop T-cell leukemias in the thymus late in the first year of life. These neoplasms arise following the appearance in the thymus of a recombinant retrovirus but can be prevented by thymectomy, indicating a role for both virus and elements of the thymic microenvironment in leukemogenesis. The intrathymic appearance of recombinant ret
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10. Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias
Signal transducer and activator of transcription (STAT) proteins comprise a seven-member family of latent cytoplasmic transcription factors that are activated through tyrosine phosphorylation by a variety of cytokines and growth factors. Aberrant activation of STATs accompanies malignant cellular transformation with resultant leukemogenesis. Constitutive act
American Society of Clinical Oncology.
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11. Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis.
A preleukemic state in mice inoculated with Moloney murine leukemia virus (Mo-MuLV) was characterized. Six to 10 weeks after neonatal inoculation, animals developed mild splenomegaly and generalized hematopoietic hyperplasia. The hyperplasia was evident from myeloid and erythroid progenitor assays. A nonleukemogenic variant, Mo+PyF101 Mo-MuLV, did not induce
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12. Fusion-protein truncation provides new insights into leukemogenesis
National Academy of Sciences.