Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature
AUTOR(ES)
Costa, Bruno Almeida; da Luz, Kaiza Vilarinho; Campos, Sarah Emanuelle Viana; Lopes, Germison Silva; Leitão, João Paulo de Vasconcelos; Duarte, Fernando Barroso
FONTE
Hematology, Transfusion and Cell Therapy
DATA DE PUBLICAÇÃO
2022
RESUMO
Abstract Introduction Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases of previously healthy young adults diagnosed with a hematologic malignancy after experiencing COVID-19, we raise the hypothesis that the SARS-Cov-2 infection could act as a trigger for leukemogenesis in predisposed individuals. Methods This was a case series performed through extraction of relevant clinical information from the medical records of three patients admitted to our Hematology unit between August 2020 and September 2020. Main Results Considering the relatively rapid development of cytopenias following recovery from COVID-19, it cannot be ruled out that SARS-Cov-2 played a role in leukemogenesis in those patients. Based on previous in vitro studies, the renin-angiotensin system imbalance induced by SARS-CoV-2 could potentially promote in vivo leukemogenesis through several mechanisms. Conclusion Despite the advances in pathophysiological and clinical characterization of COVID-19, the consequences of the pandemic to the incidence of hematologic diseases are still to be elucidated. In this context, future dissection of the status of the local bone marrow renin-angiotensin system in leukemogenesis is a clinically relevant basic research area.
Documentos Relacionados
- SARS-CoV-2 and arbovirus infection: a rapid systematic review
- Oral Antiseptic Spray Containing Phthalocyanine Solution Reduced Saliva SARS-CoV-2 Viral Load: Case Series
- Guillain-Barré syndrome associated with SARS-CoV-2 infection: a scoping review
- Subacute thyroiditis and different SARS-CoV-2 vaccine
- ESTUDOS DE QSAR PARA SARS-CoV-2