L Amino Acid Oxidase And Bothrops Pirajai
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai crude venoms and their isolated toxins, namely serine
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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2. Efeito do veneno bruto e da L-aminoácido oxidase de Bothrops pirajai em células BCR-ABL positivas / Effect of Bothrops pirajai crude venom and L-amino acid oxidase in BCR-ABL positive cells.
A leucemia mielóide crônica (LMC) é uma doença mieloproliferativa caracterizada citogeneticamente pela presença do cromossomo Philadelfia (Ph) e molecularmente pelo neogene bcr-abl1 que codifica a oncoproteína BCR-ABL com alta atividade de tirosina-quinase. A célula leucêmica BCR-ABL+ apresenta baixa adesão ao estroma medular, resistência à apopto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/07/2011
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3. Bothrops pirajai snake venom L-amino acid oxidase: in vitro effects on infection of Toxoplasma gondii in human foreskin fibroblasts
The effect of an L-amino acid oxidase isolated from Bothrops pirajai snake venom (BpirLAAO-I) was investigated on infection of Toxoplasma gondii in human foreskin fibroblasts (HFF). The cytotoxic activity of BpirLAAO-I on HFF cells showed a dose-dependent toxicity with median cytotoxic dose (TD50) of 11.8 µg/mL. BpirLAAO-I induced considerable dose-dependen
Revista Brasileira de Farmacognosia. Publicado em: 17/06/2011
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4. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
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5. Structural and functional caracterization of L-aminoácido oxidases isolated from snake Bothrops venoms / Caracterização funcional e estrutural de L-aminoácido oxidases isoladas de venenos de serpentes do gênero Bothrops
The aim of this project was the isolation of three L-aminoacid oxidases from Bothrops jararaca, Bothrops moojeni and Bothrops pirajai snake venoms, respectively, in addition to their biochemical, enzymatic, pharmacological and toxicological characterization. They were named BjarLAAO-I, BmooLAAO-I and BpirLAAO-I, respectively, and their isolation involved two
Publicado em: 2008
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6. CaracterizaÃÃo bioquÃmica e funcional de uma nova L-aminoÃcido oxidase isolada da peÃonha da serpente Bothrops pirajai
In this work we describe the isolation of a new L-amino acid oxidase (LAAO) referred to as BpirLAAO-I from Bothrops pirajai snake venom, which was highly purified using a combination of molecular exclusion, affinity and hydrophobic chromatography steps. BpirLAAO-I is a homodimeric acidic glycoprotein (approximate Mr and pI of 130,000 and 4.9, respectively),
Publicado em: 2007
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7. Caracterização bioquímica e funcional de uma nova L-aminoácido oxidase isolada da peçonha da serpente Bothrops pirajai
In this work we describe the isolation of a new L-amino acid oxidase (LAAO) referred to as BpirLAAO-I from Bothrops pirajai snake venom, which was highly purified using a combination of molecular exclusion, affinity and hydrophobic chromatography steps. BpirLAAO-I is a homodimeric acidic glycoprotein (approximate Mr and pI of 130,000 and 4.9, respectively),
Publicado em: 2007