Kvdmr1
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Placental hydroxymethylation vsmethylation at the imprinting control region 2 on chromosome 11p15.5
In addition to methylated cytosines (5-mCs), hydroxymethylcytosines (5-hmCs) are present in CpG dinucleotide-enriched regions and some transcription regulator binding sites. Unlike methylation, hydroxymethylation does not result in silencing of gene expression, and the most commonly used methods to study methylation, such as techniques based on restriction e
Braz J Med Biol Res. Publicado em: 22/10/2013
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2. Constitutional and somatic methylation status of DMRH19 and KvDMR in Wilms tumor patients
The most frequent epigenetic alterations in Wilms tumor (WT) occur at WT2, assigned to 11p15. WT2 consists of two domains: telomeric domain 1 (DMRH19) that contains the IGF2 gene and an imprinted maternally expressed transcript (H19) and centromeric domain 2 (KvDMR) that contains the genes KCNQ1, KCNQ1OT1 and CDKN1C. In this work, we used pyrosequencing and
Genet. Mol. Biol.. Publicado em: 2012
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3. In silico characterization and epigenetic analysis of in vivo and cloned cattle of the homologue region 11p15.5 involved with Beckwith-Wiedemann syndrome in humans / Caracterização in silico e análise epigenética em bovinos produzidos in vivo e por transferência nuclear da região homóloga à 11p15.5 envolvida com a síndrome de Beckwith-Wiedemann em humanos
Epigenetics is the branch of biology which studies heritable changes in genome function that occur without a change in nucleotide sequence within the DNA. One of the most studied epigenetic process is the DNA methylation, which is associated with several gene regulation mechanisms such as genomic imprinting. This type of regulation is characterized by parent
Publicado em: 2007
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4. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome
Loss of imprinting at IGF2, generally through an H19-independent mechanism, is associated with a large percentage of patients with the overgrowth and cancer predisposition condition Beckwith–Wiedemann syndrome (BWS). Imprinting control elements are proposed to exist within the KvLQT1 locus, because multiple BWS-associated chromosome rearrangements disrupt
The National Academy of Sciences.
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5. Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas
Genomic imprinting is a reversible condition that causes parental-specific silencing of maternally or paternally inherited genes. Analysis of DNA and RNA from 52 human hepatocarcinoma samples revealed abnormal imprinting of genes located at chromosome 11p15 in 51% of 37 informative samples. The most frequently detected abnormality was gain of imprinting, whi
The National Academy of Sciences.