Kaurenoic Acid
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes
Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kine
Quím. Nova. Publicado em: 2021-06
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2. KAURENOIC ACID DETERMINATION IN EXTRACT, TINCTURE AND SYRUP OF Mikania glomerata BY HPLC-QQQ-MS/MS
This work aims to develop a rapid and reliable method by HPLC-QqQ-MS/MS for identification and quantification of Kaurenoic acid (KA) in extract, tincture and syrup from Mikania glomerata. The developed method allows identifying and quantifying KA in complex samples obtained from extract marketed in pharmaceutical industry, a tincture prepared with the leaves
Quím. Nova. Publicado em: 2020-05
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3. Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria
In this work, a search for antimicrobial agents against multi-drug resistant (MDR) bacteria was undertaken. It involved two natural diterpenes of different basic skeletons, named ent-kaurenoic acid and ent-pimaradienoic acid, that were used as precursors to access 28 semi-synthetic derivatives that were also submitted to biological assays. All 30 substances
J. Braz. Chem. Soc.. Publicado em: 2019-02
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4. STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF DITERPENES FOR TREATMENT OF ALZHEIMER'S DISEASE
Alzheimer's disease is an irreversible, degenerative and age-related disease which is growing more and more with the increase in life expectancy. Kaurane diterpenes are a class of natural products available in large amounts in nature and isolated from plants grown worldwide. In the present work¸ twenty-seven kaurane diterpenes of natural origin and some rea
Quím. Nova. Publicado em: 2017-09
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5. Antimicrobial activity of Aspilia latissima (Asteraceae)
Abstract We evaluated the antimicrobial activity of Aspilia latissima - an abundant plant from the Brazilian Pantanal region - against Candida albicans, Candida parapsilosis, Candida krusei, Candida tropicalis, Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli and Staphylococcus aureus. The crude extracts and fractions showed activity in all te
Braz. J. Microbiol.. Publicado em: 2015-12
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6. Antileishmanial activity of diterpene acids in copaiba oil
Leishmaniasis is a neglected tropical disease. According to the World Health Organization, there are approximately 1.5-two million new cases of cutaneous leishmaniasis each year worldwide. Chemotherapy against leishmaniasis is based on pentavalent antimonials, which were developed more than a century ago. The goals of this study were to investigate the antil
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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7. Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases
Gliomas are the most common and malignant primary brain tumors in humans. Studies have shown that classes of kaurene diterpene have anti-tumor activity related to their ability to induce apoptosis. We investigated the response of the human glioblastoma cell line U87 to treatment with ent-kaur-16-en-19-oic acid (kaurenoic acid, KA). We analyzed cell survival
Braz J Med Biol Res. Publicado em: 11/01/2013
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8. Molecular evolution of the ent-kaurenoic acid oxidase gene in Oryzeae
We surveyed the substitution patterns in the ent-kaurenoic acid oxidase (KAO) gene in 11 species of Oryzeae with an outgroup in the Ehrhartoidaea. The synonymous and non-synonymous substitution rates showed a high positive correlation with each other, but were negatively correlated with codon usage bias and GC content at third codon positions. The substituti
Genetics and Molecular Biology. Publicado em: 16/02/2012
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9. Copaifera langsdorffii: estudo fitoquímico, validação de métodos cromatográficos e análise sazonal / Copaifera langsdorffii: phytochemical study, chromatographic method validation and seasonality role.
Copaiba refers to large trees that grow mainly in the states of Amazonas, Pará, Ceará and northern Brazil. Copaifera langsdorffii can be found in almost all regions of Brazil. Samples of its oilrresin, especially one obtained from C. langsdorffii have been used in folk medicine as anti-inflammatory, antiseptic, urinary antiseptic and wound healing. In addi
Publicado em: 2011
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10. iso-Kaurenoic acid from Wedelia paludosa D.C.
Uma recente reinvestigação das partes aéreas de Wedelia paludosa D.C. é descrita e relata, pela primeira vez, o isolamento do ácido iso-caurenóico desta espécie.
Anais da Academia Brasileira de Ciências. Publicado em: 2010-12
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11. Phytochemical study of the NortheastÂs plants: Amnona squamosa Obtaining derivatives reaction of kaurenoic acid / Estudo fitoquÃmico de plantas do Nordeste: Amnona squamosa ObtenÃÃo de Derivados Reacionais do Ãcido CaurenÃico
Annona squamosa is a common tree popularly know as âataâ. In the folk medicine is used for treatment of stomach diseases, headache, diarrhea and for removal of louse. Phytochemical investigation of EtOH and hexanic extraction using chromatographic techniques allowed identification of kaurenoic acid an 16b, 17-Dihidroxy-ent-kauran-19-oic acid. Derivative of
Publicado em: 2007
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12. New oxidized ent-kaurane and ent-norkaurane derivatives from kaurenoic acid
Novos derivados oxidados ent-caurânicos e ent-norcaurânicos foram sintetizados a partir do ácido caurenóico. Todos os produtos obtidos foram caracterizados espectroscopicamente.
Journal of the Brazilian Chemical Society. Publicado em: 2007