Jararhagin
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Avaliação da atividade antiofídica do composto p-cumarato de triacontila isolado de Bombacopsis glabra e da toxicidade aguda do extrato de Schizolobium parahyba
The use of plant extracts as antidote against animals venoms is an old practice, mainly envenomations by snakes, besides also may used as supplemental of serum therapy. Snake venoms are a rich mixture of proteins involved in a complex series of events that depends on the synergic action of these molecules. The present study explores the ability of Triacontil
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
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2. Ação da jararagina na expressão gênica e protéica de mediadores pró-inflamatórios por células endoteliais humanas. / Action of jararhagin in gene and protein expression of proinflammatory mediators by human endothelial cells.
A jararagina, isolada do veneno de Bothrops jararaca, possui efeito pró-inflamatório caracterizado por edema, liberação de citocinas e migração celular. Neste estudo, demonstramos o aumento na expressão gênica da quimiocina IL-8, moléculas de adesão (E-Selectina, V-CAM-1, I-CAM-1), CD-69, Angiopoetina-2 e MMP-10 em HUVECs estimuladas com jararagina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2011
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3. Subclonagem e expressão do domínio catalítico da jararagina: estudo do efeito das modificações pós-traducionais na atividade hemorrágica.
Metalloproteases are Zn++-dependent peptidase enzymes, richly found in Crotalidae and Viperidae snake venoms. Most snake venom metalloproteases (svMPs) are active on extracellular matrix components and this effect is thought to result in bleeding as a consequence of the basement membrane disruption in capillaries. Jararhagin is a hemorrhagic svMP from Bothro
Publicado em: 2004
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4. Caracterização de disintegrinas de venenos viperídeos como ferramentas seletivas na detecção ou inibição da função de integrinas / Characterization of viper venom disintegrins as tools for detecting and inhibiting integrin function
Integrins are membrane proteins involved in biological processes such as embriogenesis, inflammation and platelet aggregation. The alteration of their expression pattem is related to pathological disorders such as thrombosis and cancer, making integrins suitable indicators of the progression of these diseases. Thus, the α2β1 integrin, which is expr
Publicado em: 2003
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5. "Caracterização do Efeito da Jacaragina sobre a Produção e Liberação de Citocinas Pró-inflamatórias em Modelo Murino". / Effect of jararhagin on the production and release of pro-inflammatory cytokies in a murine model.
The inflammatory effect of jararhagin, a haemorrhagic toxin from Bothrops jararaca venom, was evaluated in an in vitro (Murine Peritoneal Adherent Cells-MPACs) and in vivo system (mouse footpad), through the production of TNF-a, IL-1b and IL-6 mRNA (RT-PCR) and the release of these cytokines in the culture supernatant and locally at the site of injection (EL
Publicado em: 2002
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6. PO41, uma anti-hemorragina presente no soro de Philander opossum: isolamento, caracterização e interação com metaloproteases isoladas do veneno de Bothrops jararaca. / PO41, the anti-hemorragina present in the serum of Philander opossum: isolation, characterization and interaction with metalloproteases isolated of the poison of Bothrops jararaca
An antihaemorrhagic factor from Philander opossum serum was isolated and characterizated. In order to study the neutralization effect of this inhibitor, we have developed a new methodology to isolate a PI as well as PIII SVMP from Bothrops jararaca venom (Bjv). The antihaemorrhagic protein was isolated from Philander opossum serum by DEAE-Sephacel, Phenyl Su
Publicado em: 2000