Janus Kinase
Mostrando 1-12 de 119 artigos, teses e dissertações.
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1. Partial repigmentation of vitiligo with tofacitinib, without exposure to ultraviolet radiation,
Abstract Vitiligo is a disease that causes macules and achromic and/or hypochromic patches, which can affect from small areas to the entire tegument. Treatment options are few and are generally ineffective. Recently, some case reports have appeared which show positive results with the use of Janus kinase inhibitors associated with phototherapy. This report d
An. Bras. Dermatol.. Publicado em: 2020-08
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2. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, incl
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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3. Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
ABSTRACTMyeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis in a subgr
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-10
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4. The Hirschsprung's-multiple endocrine neoplasia connection
The risk of patients with Hirschsprung's disease later developing multiple endocrine neoplasia remains a matter of concern. The multiple endocrine neoplasia 2-Hirschsprung's disease association has been shown to cosegregate in Hirschsprung's disease patients with both short- and long-segment aganglionosis, although patients with long-segment aganglionosis a
Clinics. Publicado em: 2012
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5. Philadelphia-negative chronic myeloproliferative neoplasms
Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health Organization (WHO) defined the classification of this group of diseases and in 2008 they were renamed myeloproliferative neoplasms based on
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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6. Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes
INTRODUCTION: Myelodysplastic syndromes encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, refractory cytopenia and a tendency to progress toward acute myeloid leukemia. The accumulation of genetic alterations is closely associated with the progression of myelodysplastic syndromes toward ac
Clinics. Publicado em: 2011
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7. Pro- and anti-apoptotic genes and proteins expression in bone marrow precursors and peripheral blood leukocytes in polycythemia vera patients / Expressão de genes e proteínas anti-e-pró-apoptóticas em células precursoras da medula óssea e leucócitos do sangue periférico de pacientes portadores de policitemia vera
GASPAROTTO, E.P.L. Expressão de genes e proteínas pró- e anti-apoptóticas em células precursoras da medula óssea e leucócitos do sangue periférico de pacientes portadores de policitemia vera. 2009. 185f. Tese de Doutorado. Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2009. A policitemia vera (P
Publicado em: 2009
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8. Role of SOC3 protein on the angiotensin II intracellular and the molecular cross-talk between angiotensin II and signaling in cardiac tissue of rats / Papel da proteina SOCS3 sobre a modulação do sinal intracelular da angiotensina II e sobre o cross-talk entre a sinalização da angiotensina II e da insulina em tecido cardiaco de ratos
O hormônio angiotensina II (ANGII) através de seu receptor AT1 é capaz de ativar a via de sinalização JAK/STAT. Estudos demonstram que esta via encontra-se hiper-ativada durante o desenvolvimento da hipertensão. Os mecanismos pelos quais esta via é regulada pela ANGII ainda não foram totalmente elucidados. Relatos demonstram que hormônios, citocinas
Publicado em: 2006
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9. Efeito do doador de oxido nitrico S-Nitroso-acetilcisteina sobre a sobre a sinalização celular da angiotensina II em coração e cardiomiocitos de ratos / Effect of the nitric oxide donor S-Nitroso-N-Acetylcysteine on angiotensin II signal transduction in heart and cardiomyocites of rats
Angiotensina II (AngII) desempenha um papel importante na gênese da hipertrofia miocárdica. Grande parte do estímulo hipertrófico determinado pela AngII depende da ativação de sinalização intracelular envolvendo membros das famílias de transdutores de sinais mitogen-activated-protein kinase (MAPK) e Janus Kinase (JAK)/ signal transducer and activato
Publicado em: 2005
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10. Inter-relação entre as vias de transmissão do sinal de insulina e leptina em hipotalamo e figado de ratos
Insulin and leptin have overlapping effects in the control of energy homeostasis and glucose metabolism, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyro
Publicado em: 2002
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11. The Janus kinases (Jaks)
The Janus kinase (Jak) family, including Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2), bind cytokine receptors through amino-terminal FERM domains and link them to other molecules, especially members of the signal transducer and activator of transcription (Stat) family.
BioMed Central.
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12. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
Protein-tyrosine kinases (PTKs) are critical enzymes for receptor-mediated signaling in lymphocytes. Because natural killer (NK) cells are large granular lymphocytes with specialized effector function, we set out to identify PTKs preferentially expressed in these cells. One such PTK was identified and molecularly cloned. The predicted amino acid sequence sho