Intracellular Cholesterol
Mostrando 1-12 de 159 artigos, teses e dissertações.
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1. Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo
Abstract Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world’s population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is c
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice
Abstract We investigated the effects of a turmeric extract-loaded nanoemulsion (TENE) on lipid accumulation in 3T3-L1 adipocytes and in mice fed a high fat diet (HFD). The accumulation of intracellular lipid in 3T3-L1 adipocytes was significantly inhibited by TENE, according to Oil red O and Nile Red staining. This inhibitory effect of TENE on adipocyte diff
Food Sci. Technol. Publicado em: 27/06/2019
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3. The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes
Resumo Objetivo: Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1. Método: Este estudo caso-controle realizado em com 72 crianças com diabetes tipo 1 comparadas por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de aco
J. Pediatr. (Rio J.). Publicado em: 11/04/2019
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4. Hematological and plasma biochemical parameters in a wild population of Naja naja (Linnaeus, 1758) in Sri Lanka
Abstract Background Hematological studies of any animal species comprise an important diagnostic method in veterinary medicine and an essential tool for the conservation of species. In Sri Lanka, this essential technique has been ignored in studies of many species including reptiles. The aim of the present work was to establish a reference range of hematol
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 16/03/2017
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5. Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs
Introduction Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality o
Rev. Soc. Bras. Med. Trop.. Publicado em: 2013-12
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6. Doença de Niemann-Pick tipo C : caracterização bioquímica do fenótipo clássico e sua comparação com o fenótipo variante
A doença de Niemann-Pick tipo C (NPC) é uma esfingolipidose autossômica recessiva que se caracteriza pelo acúmulo lisossômico de colesterol não-esterificado em vários tecidos, resultando em neurodegeneração progressiva, hepatoesplenomegalia e paralisia ocular vertical, entre outros sintomas. Sua manifestação ocorre geralmente entre a metade da inf
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. Glicação avançada em macrófagos diminui o conteúdo dos receptores de HDL - ABCA-1 e ABCG-1- e induz acúmulo intracelular de 7 -cetocolesterol / Advanced Glycation in macrophages decreases the content of the HDL receptor ABCA-1 and ABCG-1 - and induces intracellular accumulation of 7-ketocholesterol
Produtos de glicação avançada (AGE) alteram o metabolismo de lípides e, em especial, o efluxo de colesterol de macrófagos, por meio da redução dos receptores ABCA-1 e ABCG-1. Isto prejudica o transporte reverso de colesterol, sistema que favorece o fluxo de colesterol de macrófagos arteriais ao fígado, permitindo sua excreção na bile e eliminaçã
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/12/2011
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8. Albumina modificada por glicação avançada no diabete melito tipo 1 e 2 prejudica o transporte reverso de colesterol e favorece o acúmulo de lípides em macrófagos / Impairment in reverse cholesterol transport and macrophage lipid accumulation induced by advanced glycated albumin drawn from uncontrolled type 1 and type 2 diabetes mellitus patients
Advanced glycation end products are prevalent in diabetes mellitus and alter lipids and lipoprotein metabolism. In this study we analyzed the role of albumin, isolated from control individuals (C, n = 12) and uncontrolled type 1 (DM 1, n = 13) and type 2 (DM 2, n = 11) diabetes mellitus patients on macrophage cholesterol removal, intracellular lipid accumula
Publicado em: 2011
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9. Effect of dimethylsufoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts
Niemann-Pick type C (NPC) fibroblasts present a large concentration of cholesterol in their cytoplasm due to a still unidentified deficiency in cholesterol metabolism. The influence of dimethylsulfoxide (DMSO) on the amount of intracellular cholesterol was measured in 8 cultures of normal fibroblasts and in 7 fibroblast cultures from NPC patients. DMSO was a
Publicado em: 2010
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10. Preparation and cytotoxicity of cisplatin-containing liposomes
We encapsulated cisplatin into stealth pH-sensitive liposomes and studied their stability, cytotoxicity and accumulation in a human small-cell lung carcinoma cell line (GLC4) and its resistant subline (GLC4/CDDP). Since reduced cellular drug accumulation has been shown to be the main mechanism responsible for resistance in the GLC4/CDDP subline, we evaluated
Brazilian Journal of Medical and Biological Research. Publicado em: 14/06/2007
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11. AÃÃo dos Ãcidos graxos poliinsaturados essenciais na sÃndrome de tensÃo prÃ-menstual e as repercussÃes sobre a prolactina e o colesterol total
BACKGROUND: Essential fatty acids (EFA) deficiency has been implicated as a possible contributing factor to the premenstrual syndrome (PMS) when determining lower seric concentration of Prostaglandin E1 (PGE1). Several studies have reported a lower intracellular EFA and PGE1 concentration in women with PMS. Thus, it has been suggested that EFAâs supplementa
Publicado em: 2007
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12. Disseleneto de difenila: Um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro / Diphenyl Diselenide: an organoselenium compound with low toxicity in non rodents and importants antiatheorgenic properties
Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants that can inhibit this oxidative process might be useful in preventing atherosclerosis-related pathological conditions, such as cardiovascu
Publicado em: 2007