Intestinal Permeability
Mostrando 13-24 de 178 artigos, teses e dissertações.
-
13. IMPROVEMENT OF INTESTINAL PERMEABILITY WITH ALANYL-GLUTAMINE IN HIV PATIENTS:
ContextoA glutamina é a principal fonte de energia do enterócito e diarreia e perda de peso são frequentes em pacientes infectados pelo HIV.ObjetivoDeterminar o efeito da alanil-glutamina sobre a permeabilidade e a absorção intestinais nesses pacientes.MétodosEstudo duplo-cego, randomizado, controlado por placebo, utilizando doses isonitrogênicas de a
Arq. Gastroenterol.. Publicado em: 2013-03
-
14. Pharmacokinetic Properties In Silico Modeling for New Chemical Entities Evaluation. / Modelagem In silico de propriedades farmacocinéticas para a avaliação de candidatos a novos fármacos
The pharmacokinetic (PK) processes of absorption, distribution, metabolism and excretion (ADME), have been identified as one of the major causes of new chemical entities (NCEs) failure in early clinical trials. In silico models are receiving increased attention in recent years from the pharmaceutical industry, which is integrating a paradigm of multiple phar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2011
-
15. An HPLC-UV method for the measurement of permeability of marker drugs in the Caco-2 cell assay
The Caco-2 cell line has been used as a model to predict the in vitro permeability of the human intestinal barrier. The predictive potential of the assay relies on an appropriate in-house validation of the method. The objective of the present study was to develop a single HPLC-UV method for the identification and quantitation of marker drugs and to determine
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
-
16. Ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats
The purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. Male Wistar rats were randomly divided into 3 groups (N = 36 each): sham operated (group S), lower limb ischemia-reperfusion (group LIR), and post-conditioning (
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
-
17. Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells
The objectives of this study were to determine the effect of tumor necrosis factor alpha (TNF-α) on intestinal epithelial cell permeability and the expression of tight junction proteins. Caco-2 cells were plated onto Transwell® microporous filters and treated with TNF-α (10 or 100 ng/mL) for 0, 4, 8, 16, or 24 h. The transepithelial electrical resistance
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
-
18. Possible links between intestinal permeablity and food processing: a potential therapeutic niche for glutamine
Increased intestinal permeability is a likely cause of various pathologies, such as allergies and metabolic or even cardiovascular disturbances. Intestinal permeability is found in many severe clinical situations and in common disorders such as irritable bowel syndrome. In these conditions, substances that are normally unable to cross the epithelial barrier
Clinics. Publicado em: 2010
-
19. Avaliação in vitro da solubilidade e da permeabilidade da lamivudina e da zidovudina. Aplicações na classificação biofarmacêutica / Solubility and permeability evaluation of lamivudine and zidovudine. Biopharmaceutical classification.
A biodisponibilidade é o fator determinante da eficácia clínica de um fármaco e depende diretamente das propriedades de solubilidade e permeabilidade da substância ativa. O Sistema de Classificação Biofarmacêutica (SCB), baseado nestas características, consolidou-se nos últimos anos como ferramenta de auxílio na predição da biodisponibilidade de
Publicado em: 2010
-
20. Padronização das condições para cultura de células Caco-2 visando à obtenção de membranas viáveis ao estudo da permeabilidade in vitro da rifampicina / Standardization of culture Caco-2 cells conditions to obtain viable membranes to study the in vitro permeability of rifampicin
A permeabilidade através do epitélio intestinal tem se tornado um importante aspecto a ser determinado nas avaliações biofarmacotécnicas envolvendo fármacos e medicamentos. A técnica mais empregada para essa determinação in vitro é aquela que utiliza a cultura de células Caco-2. Entretanto, ainda são discutíveis as condições para a realizaçã
Publicado em: 2010
-
21. Estudo da barreira funcional intestinal e concentraÃÃes sÃricas de rifampicina e isoniazida em pacientes com tuberculose multirresistente / Intestinal barrier function and bioavailability of rifampin and isoniazid in multidrug-resistant tuberculosis patients in cearà state, northeast-brazil
Baixos nÃveis sangÃÃneos de drogas antituberculose podem ser causa de resistÃncia do Mycobacterium tuberculosis. Este estudo objetivou avaliar a absorÃÃo intestinal transcelular e paracelular e verificar possÃvel repercussÃo nas concentra-ÃÃes sÃricas de de rifampicina (RMP) e isoniazida (INH) em pacientes com tuberculose multirresistente (TBMR).
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/06/2009
-
22. Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects
The gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to evaluate the barrier function towards sugars after the appro
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
-
23. Avaliação dos mecanismos indutores da inflamação pulmonar decorrente da isquemia e reperfusão intestinal em camundongos geneticamente selecionados. / Evaluation of the mechanisms underlying the lung inflammation following intestinal ischemia / reperfusion (I/R) in genetically selected mice.
The aim of this study was to characterize the acute lung inflammation due to intestinal I/R in mice selected for high (AIRmax) or low (AIRmin) acute inflammatory response by means of bidirectional genetic selection. Balb/c mice were also used as a reference control of the parameters evaluated. Intestinal ischemia was induced by a 45-min clamping of the super
Publicado em: 2008
-
24. Avaliação do papel da glutamina nos desfechos relacionados ao transplante alogênico de célulastronco hematopoiéticas
Fifty-three patients with hematological malignancies who underwent allogeneic stem cell transplantation (SCT) from HLA-identical siblings were randomly assigned to receive glutamine enriched parenteral nutrition - PN (GlPN, n = 27) or standard PN (PN, n = 26), in isonitrogenous solutions. Deaths (D+100 and D+180), infections, acute GVHD, length of stay (LOS)
Publicado em: 2008