Inhibiting Factors
Mostrando 1-12 de 350 artigos, teses e dissertações.
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1. Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1α
ABSTRACT Introduction: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1α (HIF-1α). Methods: Initially, healthy male Sprague Dawley rats were treated with streptozocin to induce d
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. CCR3 antagonist impairs estradiol-induced eosinophil migration to the uterus in ovariectomized mice
Eosinophils are abundant in the reproductive tract, contributing to the remodeling and successful implantation of the embryo. However, the mechanisms by which eosinophils migrate into the uterus and their relationship to edema are still not entirely clear, since there are a variety of chemotactic factors that can cause migration of these cells. Therefore, to
Braz J Med Biol Res. Publicado em: 2020-01
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3. Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats
The progression of myocardial injury secondary to hypertension is a complex process related to a series of physiological and molecular factors including oxidative stress. This study aimed to investigate whether moderate-intensity exercise (MIE) could improve cardiac function and oxidative stress in spontaneously hypertensive rats (SHRs). Eight-week-old male
Braz J Med Biol Res. Publicado em: 16/05/2019
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4. DETERMINING FACTORS IN THE SITUATIONAL TRANSITION OF FAMILY MEMBERS WHO CARE OF ELDERLY PEOPLE WITH PARKINSON'S DISEASE
RESUMO Objetivo: investigar os fatores facilitadores e inibidores na transição situacional de familiares cuidadores de idosos com doença de Parkinson. Método: estudo qualitativo, exploratório e descritivo, com base na teoria de enfermagem de transição familiar desenvolvido com 20 familiares cuidadores de idosos com doença de Parkinson, cadastrados
Texto contexto - enferm.. Publicado em: 29/04/2019
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5. Hepatoprotective effect of Alhagi sparsifolia against Alcoholic Liver injury in mice
Overconsumption of alcohol leads to alcoholic liver disease (ALD). Natural compounds have been investigated previously for their hepatoprotective activities against liver injury. This study investigated the protective effect of Alhagi sparsifolia on ALD. Alcohol was administered to mice for three consecutive days; either alone or in combination with Alhagi s
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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6. Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes
Excessive exposure to ultraviolet (UV) rays can cause damage of the skin and may induce cancer, immunosuppression, photoaging, and inflammation. The long non-coding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) is involved in multiple human biological processes. However, its role in UVB-induced keratinocyte injury is unclear. This study was performed to
Braz J Med Biol Res. Publicado em: 11/06/2018
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7. Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections
ABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection c
Braz J Infect Dis. Publicado em: 2018-01
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8. Impact of Fungicide Residues on Polymerase Chain Reaction and on Yeast Metabolism
ABSTRACT The indiscriminate use of pesticides on grape crops is harmful for consumers´ healthin “in natura” consumption and in the ingestion of wine and grape juice. During winemaking, a rapid and efficient fermentation stage is critical to avoid proliferation of contaminating microorganisms and to guarantee the product´s quality. Polymerase chain reac
Braz. arch. biol. technol.. Publicado em: 31/10/2016
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9. Determinants of body weight regulation in humans
ABSTRACT Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have
Arch. Endocrinol. Metab.. Publicado em: 23/02/2016
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10. ORGANIZATIONAL IMPACTS OF THE ELECTRONIC PROCESSING SYSTEM OF THE BRAZILIAN SUPERIOR COURT OF JUSTICE
ABSTRACT This paper presents a study on the social and organizational impacts of the Electronic Processing System (EPS) implemented in 2008 by the Brazilian Superior Court of Justice (SCJ). This system is part of a wider transformation process involving the implementation of a new management model at the SCJ. The theoretical framework of the research conduct
JISTEM J.Inf.Syst. Technol. Manag.. Publicado em: 2015-08
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11. Fucoidan induces G1 arrest of the cell cycle in EJ human bladder cancer cells through down-regulation of pRB phosphorylation
AbstractFucoidan, a sulfated polysaccharide found in marine algae and brown seaweeds, has been shown to inhibit the in vitro growth of human cancer cells. This study was conducted in cultured human bladder cancer EJ cells to elucidate the possible mechanisms by which fucoidan exerts its anti-proliferative activity, which until now has remained poorly underst
Rev. bras. farmacogn.. Publicado em: 2015-06
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12. Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are b
Journal of Applied Oral Science. Publicado em: 2012-04