Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

AUTOR(ES)

Souza, João Antonio Chaves de, Junior, Carlos Rossa, Garlet, Gustavo Pompermaier, Nogueira, Andressa Vilas Boas, Cirelli, Joni Augusto

FONTE

Journal of Applied Oral Science

DATA DE PUBLICAÇÃO

2012-04

RESUMO

Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.

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