Inflammation Pharmacology
Mostrando 1-12 de 14 artigos, teses e dissertações.
-
1. Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name
Rev. bras. farmacogn.. Publicado em: 17/10/2019
-
2. Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats
AbstractSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g)
Rev. bras. farmacogn.. Publicado em: 2015-06
-
3. Thalassophryne nattereri fish venom: from the envenoming to the understanding of the immune system
Thalassophryne nattereri (niquim) is a venomous fish found off North and Northeast coast of Brazil, where it is known by the severity of the accidents involving humans. This review article is divided into four topics. The first one provides a brief description of the animal biology and its distribution off Brazilian coastal waters, the venom apparatus, signs
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2014
-
4. Papel dos receptores nucleares ativados por proliferadores de peroxissomos (PPAR) na periodontite induzida em ratos. / Role of peroxisome proliferator activated nuclear receptor (PPAR) in induced periodontitis in rats.
Este estudo investigou o efeito da Roziglitazona (RTZ) sobre a perda óssea alveolar induzida pela periodontite (POAIP). Durante 3 semanas, ratos receberam sal puro de RTZ (i.p.) ou a formulaço comercial AvandiaÒ (v.o.); os grupos controles receberam os repectiovos veículos (DMSO ou CMC). Duas semanas após o inicio do tratamento
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/07/2012
-
5. InteraÃÃo das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monÃxido de carbono no controle da nocicepÃÃo e da inflamaÃÃo / Interaction between cyclooxygenase-2 and heme oxygenase-1 / biliverdin / carbon monoxide pathways in nociception and inflammation control in rats and mice.
Introduction: Heme oxygenase-1 (HO-1) plays a preventive role in oxidative stress. In contrast, COX-2 is involved in the pathogenesis of many inflammatory diseases and COX-2 selective inhibition has been shown to be effective in reversing inflammation without gastric side effects. However, serious cardiovascular effects of some selective COX-2 inhibitors eme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2010
-
6. Pharmacological contribution of early-lifetime exposure of mice to 1,2-naphthoquinone (1,2-NQ) to increase pulmonary susceptibility of allergic response at a late stage of life. / Contribuição farmacológica do estudo da exposição de camundongos na fase neonatal ao poluente 1,2-naftoquinona (1,2-NQ) e sua repercussão na resposta inflamatória na fase adulta.
Este estudo consistiu em avaliar comparativamente se camundongos neonatos e adultos, quando expostos ao poluente 1,2-NQ exibiriam susceptibilidade aumentada à inflamação alérgica (ovalbumina; OVA). Camundongos adultos ou neonatos foram expostos à 1,2-NQ ou veículo (15 min por três dias). Os camundongos adultos, após 24 h, ou neonatos, após 59 dias,
Publicado em: 2009
-
7. Instilação nasal de LPS ou suco gástrico como fator exacerbador da inflamação pulmonar ocasionada pela isquemia e reperfusão intestinal em camundongos. / Intranasal instillation of LPS or gastric juice as an exacerbating factor of lung inflammation induced by intestinal ischemia and reperfusion.
A isquemia e reperfusão intestinal (I/R-i) é relevante fator para o desenvolvimento da síndrome do desconforto respiratório agudo (SDRA). A lesão tecidual decorrente da I/R-i pode ser local e em órgãos distante do sitio isquêmico, notadamente o pulmão. Indivíduos submetidos à isquemia intestinal ao tornarem-se vulneráveis, desenvolvem resposta ex
Publicado em: 2009
-
8. Avaliação do extrato do fungo caripia montagnei e de agonistas de PPAR - α no processo inflamatório
The mushrooms have been object of intense research in view of its potential raising of application in different sectors of the pharmacology and alimentary industry. Among diverse bioactive composites of polyssacharides nature that exist in the fungus the glucans are much searched. These are polymers of glucose and classified as the type of glicosidic linking
Publicado em: 2008
-
9. An overview of the effects of annexin 1 on cells involved in the inflammatory process
The concept of anti-inflammation is currently evolving with the definition of several endogenous inhibitory circuits that are important in the control of the host inflammatory response. Here we focus on one of these pathways, the annexin 1 (ANXA1) system. Originally identified as a 37 kDa glucocorticoid-inducible protein, ANXA1 has emerged over the last deca
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
-
10. Time course evaluation of vascular tonus and superoxide production from isolated purines in aorta of endotoxemics Wistar rats / "Avaliação temporal da regulação do tônus vascular e da produção de superóxido induzido por purinas em aorta isolada de ratos Wistar endotoxêmicos"
Septic patients can evolve for septic shock and 40% of these survive. We characterize the experimental model we evaluate involved factors in the inflammation and evaluate the modulation caused by purines (ATP/ADP) in the superoxide quantification (O2-) and in the vascular reactivity of isolated aorta. The results suggest that in isolated aorta of endotoxemic
Publicado em: 2005
-
11. "Determinantes funcionais e morfológicos de ação de droga sobre os pulmões utilizando um modelo experimental em cobaias sob uso do cloridrato de fluoxetina" / Functional and morphological determinants of drug action on the lungs through an experimental model in guinea pigs under use of fluoxetine
Muito se tem pesquisado sobre os efeitos adversos dos antidepressivos tricíclicos (p.e. imipramina) sobre o sistema respiratório, embora pouco ou quase nada se encontre com relação a tal aspecto na literatura médica sobre a fluoxetina (Prozac®) um inibidor seletivo da recaptação de serotonina, até porque esta droga começou a ser utilizada somente
Publicado em: 2005
-
12. Mediators and receptors in the resolution of inflammation: drug targeting opportunities
The active resolution of inflammation is recognized as offering new opportunities to generate novel anti-inflammatory agents. The emerging appreciation of the importance of active resolution in regulation of inflammation also creates an imperative to examine developing and existing agents for their potential to influence these pathways. This themed issue of
Blackwell Publishing Ltd.