Time course evaluation of vascular tonus and superoxide production from isolated purines in aorta of endotoxemics Wistar rats / "Avaliação temporal da regulação do tônus vascular e da produção de superóxido induzido por purinas em aorta isolada de ratos Wistar endotoxêmicos"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Septic patients can evolve for septic shock and 40% of these survive. We characterize the experimental model we evaluate involved factors in the inflammation and evaluate the modulation caused by purines (ATP/ADP) in the superoxide quantification (O2-) and in the vascular reactivity of isolated aorta. The results suggest that in isolated aorta of endotoxemics rats, ATP and ADP increase the endothelial nitric oxide synthase (NOS) however just ATP reduces the bio availability of O2-, probably for the re-couples of the endothelial NOS synthase

ASSUNTO(S)

endothelium vascular nucleotÍdeos de purina/farmacologia endotoxemia nitric oxide ratos wistar oxidative stress endotoxemia endotÉlio vascular estresse oxidativo aorta purine nucleotides/pharmacology Óxido nÍtrico aorta rats wistar

ACESSO AO ARTIGO

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