Induced Pluripotent Stem Cells
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system
ABSTRACT Introduction Sickle cell disease (SCD) is a monogenic disease and it is estimated that 300,000 infants are born annually with it. Most treatments available are only palliative, whereas the allogeneic hematopoietic stem cell transplantation offers the only potential cure for SCD. Objective Generation of human autologous cells, when coupled with ind
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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2. Oocytes, embryos and pluripotent stem cells from a biomedical perspective
Abstract The veterinary and animal science professions are rapidly developing and their inherent and historical connection to agriculture is challenged by more biomedical and medical directions of research. While some consider this development as a risk of losing identity, it may also be seen as an opportunity for developing further and more sophisticated co
Anim. Reprod.. Publicado em: 28/11/2019
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3. Células-tronco de pluripotência induzida: papel da epigenética na reprogramação e sua aplicabilidade clínica
Resumo As células-tronco de pluripotência induzida (CTPI) ou do inglês induced pluripotent stem cells (iPSCs) são células somáticas reprogramadas para o estado embrionário por meio da expressão de fatores ectópicos de transcrição específicos, tornando-as um alvo promissor para a medicina regenerativa. Apesar das CTPI compartilharem característic
Rev. Assoc. Med. Bras.. Publicado em: 2017-02
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4. Multipotent male germline stem cells (mGSCs) from neonate porcine testis
ABSTRACT Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, during which unlimited spermatozoa is produced daily derived from SSCs in the testis throughout life of the male. Germline stem (GS) cells can be isolated from spermatogonia, which shared the characteristics of SSCs and embryonic stem cells (ESCs), and can be passaged stably in
Braz. arch. biol. technol.. Publicado em: 08/03/2016
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5. Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy
Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade. The causes of this metabolic disease include dysfunction and/or insufficient number of β cells. Existing diabetes mellitus treatments do not reverse or control the disease. Therefore, β-cell mass restoration might be a promising treatment. Severa
Braz J Med Biol Res. Publicado em: 10/07/2015
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6. VP22 herpes simplex virus protein can transduce proteins into stem cells
The type I herpes simplex virus VP22 tegument protein is abundant and well known for its ability to translocate proteins from one cell to the other. In spite of some reports questioning its ability to translocate proteins by attributing the results observed to fixation artifacts or simple attachment to the cell membrane, VP22 has been used to deliver several
Braz J Med Biol Res. Publicado em: 01/02/2013
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7. Biotechnological approaches to the treatment of aspermatogenic men
Aspermatogenesis is a severe impairment of spermatogenesis in which germ cells are completely lacking or present in an immature form, which results in sterility in approximately 25% of patients. Because assisted reproduction techniques require mature germ cells, biotechnology is a valuable tool for rescuing fertility while maintaining biological fatherhood.
Clinics. Publicado em: 2013
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8. Reprogramação de células mesenquimais de tecido adiposo em células-tronco pluripotentes por meio de proteína de fusão TAT / Nuclear reprogramming of adipose-tissue mesenchymal stem cells into pluripotent stem cells using TAT fusion protein
Os vírus são eficazes na transferência de genes em células devido aos seus mecanismos especializados. No entanto, vírus como veículos de entrega de genes podem acarretar em problemas, particularmente quando proposto para reprogramar células somáticas em células-tronco pluripotentes induzidas (iPS) visando utilização terapêutica. No presente estud
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2012
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9. The gene expression profiles of induced pluripotent stem cells (iPSCs) generated by a non-integrating method are more similar to embryonic stem cells than those of iPSCs generated by an integrating method
Induced pluripotent stem cells (iPSCs) obtained by the ectopic expression of defined transcription factors have tremendous promise and therapeutic potential for regenerative medicine. Many studies have highlighted important differences between iPSCs and embryonic stem cells (ESCs). In this work, we used meta-analysis to compare the global transcriptional pro
Genetics and Molecular Biology. Publicado em: 26/07/2012
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10. Identificação de genes e vias associadas aos transtornos do espectro autista / Identification of genes and pathways associated to autism spectrum disorders
Os transtornos do espectro autista (TEA) são um grupo de doenças neuropsiquiátricas caracterizadas por um prejuízo na capacidade de comunicação e de interação social e por padrões comportamentais estereotipados. Os TEA são geneticamente heterogêneos o que dificulta a identificação das alterações genéticas que estão contribuindo para estes tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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11. O uso de células-tronco adultas em modelos experimentais de crises convulsivas. / The use of adult stem cells in experimental models of seizures.
In Brazil, it is estimated that epilepsy affects from 2% of the population, about three million people at different ages and social classes. The use of antiepileptic drugs is the most common form of seizure control, although about 50- 70% of patients with epilepsy are refractory to medication. Because of difficulties in finding effective treatments, it is cr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2010
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12. Avaliação dos efeitos do extrato de Chlorella vulgaris sobre a resposta imunologica do tipo celular em camundongos expostos ao chumbo e infectados com Listeria monocytogenes
In this work, we investigated the effects of Chlorella vulgaris extract (CVE) in lead-exposed and Listeria monocytogenes infected mice. Experiments were carried out in mice treated simultaneously with CVE and lead acetate for 10 days. At the end of this period, the animals were infected. The capacity of CVE to prevent the myelosuppression induced by lead was
Publicado em: 2005